2022
Multi-task deep learning-based survival analysis on the prognosis of late AMD using the longitudinal data in AREDS.
Ghahramani G, Brendel M, Lin M, Chen Q, Keenan T, Chen K, Chew E, Lu Z, Peng Y, Wang F. Multi-task deep learning-based survival analysis on the prognosis of late AMD using the longitudinal data in AREDS. AMIA Annual Symposium Proceedings 2022, 2021: 506-515. PMID: 35308963.Peer-Reviewed Original ResearchMeSH KeywordsDeep LearningDisease ProgressionFundus OculiHumansMacular DegenerationPrognosisSurvival AnalysisConceptsAge-related macular degenerationImage featuresMulti-task learning frameworkConvolutional neural networkVision lossLate age-related macular degenerationEye Disease StudyLearning frameworkNeural networkFundus photographsPatient riskMacular degenerationStandard featuresSevere formComplex featuresSurvival analysisCurrent visitLongitudinal dataDisease StudyHistorical dataRapid paceFeaturesNetworkAREDSPatients
2021
Multimodal, multitask, multiattention (M3) deep learning detection of reticular pseudodrusen: Toward automated and accessible classification of age-related macular degeneration
Chen Q, Keenan T, Allot A, Peng Y, Agrón E, Domalpally A, Klaver C, Luttikhuizen D, Colyer M, Cukras C, Wiley H, Magone M, Cousineau-Krieger C, Wong W, Zhu Y, Chew E, Lu Z, Group F. Multimodal, multitask, multiattention (M3) deep learning detection of reticular pseudodrusen: Toward automated and accessible classification of age-related macular degeneration. Journal Of The American Medical Informatics Association 2021, 28: 1135-1148. PMID: 33792724, PMCID: PMC8200273, DOI: 10.1093/jamia/ocaa302.Peer-Reviewed Original ResearchMeSH KeywordsAgedComputer SimulationDatasets as TopicDeep LearningDiagnosis, Computer-AssistedFemaleFundus OculiHumansMacular DegenerationMaleRetinal DrusenConceptsColor fundus photographyAge-related macular degenerationFundus autofluorescenceReticular pseudodrusenMacular degenerationStandard color fundus photographyReceiver-operating characteristic curveAdvanced imaging modalitiesExternal validationRetinal specialistsAMD featuresFundus photographyGeographic atrophyPigmentary abnormalitiesAMD diagnosisImaging modalitiesCharacteristic curvePseudodrusenDegeneration
2020
Deep Learning Automated Detection of Reticular Pseudodrusen from Fundus Autofluorescence Images or Color Fundus Photographs in AREDS2
Keenan T, Chen Q, Peng Y, Domalpally A, Agrón E, Hwang C, Thavikulwat A, Lee D, Li D, Wong W, Lu Z, Chew E. Deep Learning Automated Detection of Reticular Pseudodrusen from Fundus Autofluorescence Images or Color Fundus Photographs in AREDS2. Ophthalmology 2020, 127: 1674-1687. PMID: 32447042, PMCID: PMC11079794, DOI: 10.1016/j.ophtha.2020.05.036.Peer-Reviewed Original Research