Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue
Hill DA, Lim HW, Kim YH, Ho WY, Foong YH, Nelson VL, Nguyen HCB, Chegireddy K, Kim J, Habertheuer A, Vallabhajosyula P, Kambayashi T, Won KJ, Lazar MA. Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e5096-e5105. PMID: 29760084, PMCID: PMC5984532, DOI: 10.1073/pnas.1802611115.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsExosomesFemaleHumansInflammationMacrophagesMiceMice, Inbred C57BLObesityTetraspanin 29TranscriptomeConceptsMultiple distinct populationsUnique tissue distributionTissue macrophage subsetsChromatin landscapeDistinct macrophage populationsTranscriptional mechanismsGene programObese fat tissueGene expressionDistinct populationsFunctional differencesAdipocyte physiologyCrown-like structuresAdipose tissueMacrophage populationsFunctional heterogeneityATM populationsTissue distributionHuman adipose tissueMacrophage subsetsPhysiological changesFat cellsAdoptive transferBody massTranscriptomeDonor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation
Habertheuer A, Korutla L, Rostami S, Reddy S, Lal P, Naji A, Vallabhajosyula P. Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation. Journal Of Thoracic And Cardiovascular Surgery 2018, 155: 2479-2489. PMID: 29499866, DOI: 10.1016/j.jtcvs.2017.12.125.Peer-Reviewed Original ResearchConceptsEarly acute rejectionDonor heartsAcute rejectionHeart transplantationStudy armsImmunologic rejectionMaintenance armHeterotopic heart transplantation modelAllogeneic heart transplantationTime pointsHeart transplantation modelHeterotopic heart transplantationAbsence of rejectionNovel biomarker platformDevelopment of biomarkersNoninvasive monitoringTransplant heartCardiac allograftsImmunocompetent recipientsAllograft monitoringImmunodeficient recipientsRecipient circulationTransplantation modelDay 1Total plasma