2011
Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay
Tena A, Vallabhajosyula P, Hawley RJ, Griesemer A, Yamada K, Sachs DH. Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay. Transplantation 2011, 91: 639-644. PMID: 21285918, PMCID: PMC3255479, DOI: 10.1097/tp.0b013e31820b6b52.Peer-Reviewed Original ResearchConceptsThymic tissueT cellsPeripheral bloodSjTREC levelsT-cell receptor excision circlesPeripheral blood mononuclear cellsPeripheral T cell poolT-cell receptor gene rearrangementsMemory T cellsT cell poolBlood mononuclear cellsNaïve T cellsReceptor gene rearrangementsQuantitative PCRDiscordant pigNative thymusThymic biopsiesGraft survivalKidney transplantPolymerase chain reaction analysisExcision circlesMononuclear cellsSurgical removalChain reaction analysisXenogeneic barriers
2007
Vascularized composite islet-kidney transplantation in a miniature swine model
Vallabhajosyula P, Griesemer A, Yamada K, Sachs DH. Vascularized composite islet-kidney transplantation in a miniature swine model. Cell Biochemistry And Biophysics 2007, 48: 201-207. PMID: 17709890, DOI: 10.1007/s12013-007-0027-4.Peer-Reviewed Original ResearchConceptsThymic tissueIslet equivalentsEnd-stage diabetic nephropathyType I diabetic patientsAllogeneic thymic tissueRecipient body weightLong-term toleranceLong-term survivalMiniature swine modelKidney allograftsMHC barriersDiabetic nephropathyAllogeneic isletsAllogeneic transplantationDiabetic hyperglycemiaDiabetic patientsThymic componentsTreatment regimensPortal veinRenal capsuleOrgan transplantsAutologous isletsMiniature swineTransplantationBody weight