2017
Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet–Kidney Transplantation
Vallabhajosyula P, Hirakata A, Weiss M, Griesemer A, Shimizu A, Hong H, Habertheuer A, Tchipashvili V, Yamada K, Sachs DH. Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet–Kidney Transplantation. Cell Transplantation 2017, 26: 1755-1762. PMID: 29338381, PMCID: PMC5784526, DOI: 10.1177/0963689717732993.Peer-Reviewed Original ResearchConceptsDiabetic stateIslet transplantationLarge animal modelEngraftment periodIslet engraftmentControl donorsIslet equivalentsAnimal modelsLong-term islet functionSimilar glucose tolerance testsDonor animalsChronic diabetic stateEnd-organ injuryAutologous islet transplantationGlucose tolerance testMiniature swine modelNephrectomized recipientsTotal pancreatectomyDiabetic nephropathyRecipient weightGlycemic controlOrgan injuryTolerance inductionDonor weightIschemic factors
2007
Vascularized composite islet-kidney transplantation in a miniature swine model
Vallabhajosyula P, Griesemer A, Yamada K, Sachs DH. Vascularized composite islet-kidney transplantation in a miniature swine model. Cell Biochemistry And Biophysics 2007, 48: 201-207. PMID: 17709890, DOI: 10.1007/s12013-007-0027-4.Peer-Reviewed Original ResearchConceptsThymic tissueIslet equivalentsEnd-stage diabetic nephropathyType I diabetic patientsAllogeneic thymic tissueRecipient body weightLong-term toleranceLong-term survivalMiniature swine modelKidney allograftsMHC barriersDiabetic nephropathyAllogeneic isletsAllogeneic transplantationDiabetic hyperglycemiaDiabetic patientsThymic componentsTreatment regimensPortal veinRenal capsuleOrgan transplantsAutologous isletsMiniature swineTransplantationBody weight