2024
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findings
2017
Outcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly
Kilic A, Arnaoutakis GJ, Bavaria JE, Sultan I, Desai ND, Vallabhajosyula P, Williams ML, Milewski RK, Szeto WY. Outcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly. The Annals Of Thoracic Surgery 2017, 104: 1522-1530. PMID: 28648536, DOI: 10.1016/j.athoracsur.2017.03.067.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationCirculatory Arrest, Deep Hypothermia InducedCohort StudiesElective Surgical ProceduresFemaleGeriatric AssessmentHospital MortalityHumansMaleMiddle AgedPlastic Surgery ProceduresPostoperative CarePostoperative ComplicationsPrognosisPropensity ScoreRegistriesRetrospective StudiesRisk AssessmentSex FactorsSurvival AnalysisTreatment OutcomeConceptsModerate hypothermic circulatory arrestAntegrade cerebral perfusionHypothermic circulatory arrestHemiarch reconstructionElderly patientsAneurysmal diseaseOperative mortalityCerebral perfusionCirculatory arrestConcomitant aortic valve replacementRisk-adjusted operative mortalityCoronary artery bypassOperative mortality rateAortic valve replacementGreater comorbidity burdenLow operative mortalityOverall stroke rateSafe strategyIntensive care unitComorbidity burdenArtery bypassHospital stayRoot replacementValve replacementCare unit
2016
The Impact of Deep Versus Moderate Hypothermia on Postoperative Kidney Function After Elective Aortic Hemiarch Repair
Arnaoutakis GJ, Vallabhajosyula P, Bavaria JE, Sultan I, Siki M, Naidu S, Milewski RK, Williams ML, Hargrove WC, Desai ND, Szeto WY. The Impact of Deep Versus Moderate Hypothermia on Postoperative Kidney Function After Elective Aortic Hemiarch Repair. The Annals Of Thoracic Surgery 2016, 102: 1313-1321. PMID: 27318775, DOI: 10.1016/j.athoracsur.2016.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAorta, ThoracicAortic Aneurysm, ThoracicCause of DeathCerebrovascular CirculationCirculatory Arrest, Deep Hypothermia InducedCohort StudiesDatabases, FactualElective Surgical ProceduresFemaleFollow-Up StudiesGlomerular Filtration RateHospital MortalityHumansHypothermia, InducedLogistic ModelsMaleMiddle AgedMultivariate AnalysisPerfusionPostoperative ComplicationsRetrospective StudiesSurvival AnalysisTreatment OutcomeConceptsAntegrade cerebral perfusionRetrograde cerebral perfusionAcute kidney injuryModerate hypothermic circulatory arrestDeep hypothermic circulatory arrestHypothermic circulatory arrestGlomerular filtration rateHemiarch repairCerebral perfusionCirculatory arrestEjection fractionAneurysmal diseaseLower baseline glomerular filtration rateOccurrence of AKIAortic cross-clamp timeBaseline glomerular filtration rateHigher acute kidney injuryLonger cardiopulmonary bypass timeLow preoperative ejection fractionPostoperative acute kidney injuryAortic hemiarch replacementBaseline renal dysfunctionCerebral perfusion strategyCerebral protection strategiesDistal organ protection