2006
71 SIMVASTATIN ATTENUATES ACUTE LUNG INJURY INDUCED BY ISCHEMIA-REPERFUSION IN RODENTS.
Moreno L, Jacobson J, Bonde P, Garcia J. 71 SIMVASTATIN ATTENUATES ACUTE LUNG INJURY INDUCED BY ISCHEMIA-REPERFUSION IN RODENTS. Journal Of Investigative Medicine 2006, 54: s355. DOI: 10.2310/6650.2005.x0015.70.Peer-Reviewed Original ResearchIR injuryLung injuryAnimal modelsACUTE LUNG INJURY INDUCEDLung tissue myeloperoxidase activityBronchoalveolar lavage cell countsIschemia-reperfusion lung injuryIndices of inflammationIR lung injuryLavage cell countsLung preservation techniquesTissue myeloperoxidase activityHours of reperfusionLeft pulmonary arteryPotential therapeutic roleAnesthetized Sprague-DawleySignificant clinical impactProfound clinical implicationsLung transplantationTissue MPOAlveolar damageMyeloperoxidase activityTransplant failurePulmonary arterySimvastatin treatment
2004
Transfection with keratinocyte growth factor 1 cDNA with electroporation improves wound healing in an aged mouse model
Marti G, Makary M, Ferguson M, Wang J, Dieb R, Marti A, Lin M, Bonde P, Duncan M, Harmon J. Transfection with keratinocyte growth factor 1 cDNA with electroporation improves wound healing in an aged mouse model. Journal Of Surgical Research 2004, 121: 320-321. DOI: 10.1016/j.jss.2004.07.175.Peer-Reviewed Original ResearchAged animal modelsAnimal modelsWound sizeWound closureAged mouse modelMice 6 weeksKGF-1Young animalsAverage wound sizeT-testStudent's t-testCutaneous wound closureFull-thickness woundsElderly miceAged miceBALBc miceMouse modelAge groupsDay 12DNA expression vectorsGrowth factorMiceWound areaProliferative capacityUntreated woundsInhibition of the EGFR and hedgehog signaling pathways demonstrate potent growth inhibition in an animal model of esophageal carcinogenesis
Sui G, Bonde P, Dhara S, Marti G, Freguson M, Wang J, Jaffee E, Duncan M, Montgomery E, Maitra A, Harmon J. Inhibition of the EGFR and hedgehog signaling pathways demonstrate potent growth inhibition in an animal model of esophageal carcinogenesis. Journal Of Surgical Research 2004, 121: 278-279. DOI: 10.1016/j.jss.2004.07.040.Peer-Reviewed Original ResearchEpidermal growth factor receptorSignificant growth inhibitionEsophageal carcinogenesisCell linesVivo growthGrowth inhibitionSquamous cell carcinomaSprague-Dawley ratsReliable preclinical modelsHh pathway antagonistsImportant oncogenic pathwaysBilious refluxMock-treated cellsGrowth factor receptorAdenosquamous cancerCell carcinomaEsophageal cancerSD ratsPreclinical modelsSubcutaneous xenograftsAthymic miceSmall molecule inhibitorsAnimal modelsPotent growth inhibitionExperimental therapeutics