Severe non-infective systemic inflammatory response syndrome, shock, and end-organ dysfunction after zoledronic acid administration in a child
Trivedi S, Al-Nofal A, Kumar S, Tripathi S, Kahoud R, Tebben P. Severe non-infective systemic inflammatory response syndrome, shock, and end-organ dysfunction after zoledronic acid administration in a child. Osteoporosis International 2016, 27: 2379-2382. PMID: 26892041, DOI: 10.1007/s00198-016-3528-4.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsBone Density Conservation AgentsChildDiphosphonatesHumansImidazolesMaleOsteoporosisSystemic Inflammatory Response SyndromeZoledronic AcidConceptsZoledronic acidPediatric patientsMethodsA 7-year-old boyInfusion of zoledronic acidModerate acute respiratory distress syndromeNon-infective systemic inflammatory response syndromeIncreased bone mineral densitySystemic inflammatory response syndromeElevated C-reactive proteinAcute respiratory distress syndromeIntensive cardiorespiratory supportZoledronic acid infusionAbnormal coagulation profileZoledronic acid therapyHypoxic-ischemic encephalopathyPediatric intensive care unitEnd-organ dysfunctionZoledronic acid administrationInflammatory response syndromeBone mineral densityRespiratory distress syndromeRisk of fractureC-reactive proteinIncreased oxygen requirementIntensive care unit