2019
Patterns of amiodarone-induced thyroid dysfunction in infants and children
Creo A, Anderson H, Cannon B, Lteif A, Kumar S, Tebben P, Iqbal A, Ramakrishna A, Pittock S. Patterns of amiodarone-induced thyroid dysfunction in infants and children. Heart Rhythm 2019, 16: 1436-1442. PMID: 30904484, DOI: 10.1016/j.hrthm.2019.03.015.Peer-Reviewed Original ResearchConceptsAmiodarone-induced thyroid dysfunctionThyroid function testsThyroid-stimulating hormoneThyroid dysfunctionPediatric patientsTSH valuesThyroid-stimulating hormone elevationHeart Rhythm Society guidelinesThyroid-stimulating hormone valuesDegree of TSH elevationPeak TSH valueBrain developmentOptimal screening frequencyType of heart diseaseLong-term groupAmiodarone therapyTSH elevationInotropic supportUntreated hypothyroidismHypothyroid childrenAmiodarone initiationRetrospective cohortSociety guidelinesAmiodaroneYoung children
2018
Mild subclinical hypothyroidism is associated with paediatric dyslipidaemia
Dahl A, Iqbal A, Lteif A, Pittock S, Tebben P, Kumar S. Mild subclinical hypothyroidism is associated with paediatric dyslipidaemia. Clinical Endocrinology 2018, 89: 330-335. PMID: 29846957, DOI: 10.1111/cen.13752.Peer-Reviewed Original ResearchConceptsMild subclinical hypothyroidismElevated non-HDL cholesterolSubclinical hypothyroidismEuthyroid childrenElevated total cholesterolAssociated with higher ratesNon-HDL cholesterolTotal cholesterolLipid profilePresence of thyroid autoimmunityRandomized placebo-controlled studyNon-HDL cholesterol levelsAssociated with total cholesterolPlacebo-controlled studyMeasurement of TSHCompare lipid profilesTSH levelsThyroid autoimmunityHigher ratesFree thyroxineCardiometabolic consequencesOdds ratioControlled studiesCholesterol levelsHypothyroidism