THU461 Severe Hypercalcemia Associated With Perinatal Hypophosphatasia While Receiving Enzyme Replacement Therapy
Salama M, Tebben P. THU461 Severe Hypercalcemia Associated With Perinatal Hypophosphatasia While Receiving Enzyme Replacement Therapy. Journal Of The Endocrine Society 2023, 7: bvad114.422. PMCID: PMC10555444, DOI: 10.1210/jendso/bvad114.422.Peer-Reviewed Original ResearchDietary calcium intakeCalcium intakeAsfotase alfaPerinatal hypophosphatasiaMonths of ageTissue non-specific alkaline phosphataseSevere hypercalcemiaAA doseIncreased to 3 mg/kgLow calcium intakeDefective bone mineralizationLong-term therapyEnzyme replacement therapyTreated with AAPrenatal ultrasoundCalcitonin therapyPersistent hypercalcemiaInitial presentationAA therapyHydroxyvitamin DNon-specific alkaline phosphataseCalcium supplementationParathyroid hormoneReplacement therapyInitial management