Increasing Incidence of Nutritional Rickets: A Population-Based Study in Olmsted County, Minnesota
Thacher T, Fischer P, Tebben P, Singh R, S. S, Maxson J, Yawn B. Increasing Incidence of Nutritional Rickets: A Population-Based Study in Olmsted County, Minnesota. Mayo Clinic Proceedings 2013, 88: 176-183. PMID: 23374621, PMCID: PMC3612965, DOI: 10.1016/j.mayocp.2012.10.018.Peer-Reviewed Original ResearchConceptsDiagnostic codesRadiographic evidence of ricketsOlmsted County, MinnesotaRochester Epidemiology Project dataAssociated with black raceCommunity-based populationRisk factorsVitamin D deficiencyPopulation-based studyNutritional ricketsEvidence of ricketsIncidence of nutritional ricketsRecord abstractionEvaluation of risk factorsNonwhite race/ethnicityLeg painD deficiencyOlmsted CountyOutcome measuresIncidence rateRadiographic evidenceLow birth weightAge- and sex-matched controlsGenu varumBlack raceClinical spectrum of hypophosphatasia diagnosed in adults
Berkseth K, Tebben P, Drake M, Hefferan T, Jewison D, Wermers R. Clinical spectrum of hypophosphatasia diagnosed in adults. Bone 2013, 54: 21-27. PMID: 23352924, DOI: 10.1016/j.bone.2013.01.024.Peer-Reviewed Original ResearchConceptsMusculoskeletal painAbsence of genetic testingUrine phosphoethanolamineHistory of fractureAdult hypophosphatasiaHip/femoral neckClinical manifestationsClinical spectrum of hypophosphatasiaSubtrochanteric femur fracturesIncident fracturesLow serum alkaline phosphataseDiagnostic codesIliac crest bone biopsiesAlkaline phosphataseFracture patientsFamily historyConsistent with osteomalaciaEvidence of osteomalaciaInclusion criteriaGenetic testingFemur fracturesMedical recordsSerum alkaline phosphataseSymptomatic subjectsRadiographic chondrocalcinosis