2019
Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression
Zhou B, Qi F, Wu F, Nie H, Song Y, Shao L, Han J, Wu Z, Saiyin H, Wei G, Wang P, Ni T, Qian F. Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression. MBio 2019, 10: 10.1128/mbio.00937-19. PMID: 31363026, PMCID: PMC6667616, DOI: 10.1128/mbio.00937-19.Peer-Reviewed Original ResearchConceptsAntiviral immune responseImmune responseInnate immune responseNF-κB subunitsExpression of RelADeficient miceI interferonAntiviral responseVirus-induced cytokine productionHost genome instabilityEndogenous retrovirusesNF-κB signalingType I interferonRNA virus infectionViral RNA mimicViral loadCytokine productionViral challengeVirus infectionLong noncoding RNADeleterious roleRelA expressionViral replicationViral sensorsReduced expression
2018
Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3
Wang K, Zou C, Wang X, Huang C, Feng T, Pan W, Wu Q, Wang P, Dai J. Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3. PLOS Pathogens 2018, 14: e1007287. PMID: 30142214, PMCID: PMC6126873, DOI: 10.1371/journal.ppat.1007287.Peer-Reviewed Original ResearchMeSH KeywordsA549 CellsAnimalsAnophelesCells, CulturedDengue VirusGene Expression RegulationHEK293 CellsHeLa CellsHuman Umbilical Vein Endothelial CellsHumansInterferon Type IMiceProtein Processing, Post-TranslationalRNA HelicasesSerine EndopeptidasesTripartite Motif ProteinsUbiquitinationUbiquitin-Protein LigasesUp-RegulationViral Nonstructural ProteinsVirus ReplicationConceptsInterferon-stimulated genesI interferonNonstructural protein 3DENV replicationMost interferon-stimulated genesProtein 3Dengue virus infectionDengue virus replicationType I interferonViral nonstructural protein 3DENV infectionImmunocompetent miceVirus infectionViral infectionAntiviral activityVirus replicationVivo studiesInfectionTripartite motif (TRIM) proteinsTRIM family membersViral nonstructural proteinsFamily membersNonstructural proteinsTRIM69E3 ubiquitin ligase activity
2011
ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro
Dai J, Pan W, Wang P. ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro. Virology Journal 2011, 8: 468. PMID: 21992229, PMCID: PMC3215395, DOI: 10.1186/1743-422x-8-468.Peer-Reviewed Original ResearchConceptsWest Nile virusNon-infected cellsWNV infectionViral infectionWest Nile virus infectionWest Nile meningoencephalitisInterferon beta 1Type I interferonCellular antiviral responseVirus infectionI interferonAntiviral responseFlaviviridae familyRAW264.7 cellsDENVInfectionConclusionsThese findingsBeta 1Protein ISGylationGene 15SOCS3 siRNANile virusCausative agentExact roleISG15