2024
An evolutionarily conserved ubiquitin ligase drives infection and transmission of flaviviruses
Wu L, Zhang L, Feng S, Chen L, Lin C, Wang G, Zhu Y, Wang P, Cheng G. An evolutionarily conserved ubiquitin ligase drives infection and transmission of flaviviruses. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2317978121. PMID: 38593069, PMCID: PMC11032495, DOI: 10.1073/pnas.2317978121.Peer-Reviewed Original ResearchConceptsNonstructural proteinsSingle-stranded RNA genomeER-associated degradationE3 ligase HRD1Individual functional proteinsFlavivirus infectionCellular fitnessRNA genomeUbiquitin systemFlavivirus NS4AFunctional proteinsFlavivirus proteinsLysine residuesMammalian hostsMosquito-borne flavivirusSmall molecule inhibitorsStructural proteinsHrd1Viral proteinsProgeny virionsUbiquitinPotential therapeutic targetDENV2 infectionProteinNS4A
2022
A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness
Zhang H, Zhu Y, Liu Z, Peng Y, Peng W, Tong L, Wang J, Liu Q, Wang P, Cheng G. A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness. Cell 2022, 185: 2510-2522.e16. PMID: 35777355, DOI: 10.1016/j.cell.2022.05.016.Peer-Reviewed Original ResearchSkin microbiotaMosquito-transmitted flavivirusDengue patientsFlavivirus infectionFlavivirus life cycleDietary administrationHealthy peopleCommensal bacteriaZika virusHost skinMosquito attractivenessArboviral transmissionRELMαAedes mosquitoesMicrobiotaMosquito olfactionInfected hostAntimicrobial proteinsHematophagous arthropodsHost-seeking activityMosquitoesIsotretinoinPatientsInfectionMice
2021
A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes
Zhu Y, Zhang C, Zhang L, Yang Y, Yu X, Wang J, Liu Q, Wang P, Cheng G. A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes. Cell Reports 2021, 37: 110091. PMID: 34910910, DOI: 10.1016/j.celrep.2021.110091.Peer-Reviewed Original Research
2015
A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes
Xiao X, Zhang R, Pang X, Liang G, Wang P, Cheng G. A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes. PLOS Pathogens 2015, 11: e1004848. PMID: 25915054, PMCID: PMC4411065, DOI: 10.1371/journal.ppat.1004848.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsAntiviral AgentsApoptosisBrainCell LineCell MembraneDengue VirusDrosophila melanogasterDrosophila ProteinsEncephalitis Virus, JapaneseFemaleHost-Pathogen InteractionsHumansInsect ProteinsNerve Tissue ProteinsNeuronsPhylogenyProtein Interaction Domains and MotifsRecombinant ProteinsViral Envelope ProteinsVirus InternalizationConceptsMosquito nervous systemCentral nervous systemJapanese encephalitis virusNervous systemFlaviviral infectionsDengue virusSindbis virusAntiviral mechanismMembrane targetingDramatic pathologyPlasma membraneAnti-flavivirus activityMosquito cellsSurface envelope proteinMosquito lifespanNatural vectorCulex pipiensHuman viral diseasesNeural cellsFlavivirus infectionEnvelope proteinFunctional blockadeNeural apoptosisMosquito behaviorViral infection