2022
The noncanonical inflammasome in health and disease
Cahoon J, Yang D, Wang P. The noncanonical inflammasome in health and disease. Infectious Medicine 2022, 1: 208-216. PMID: 38077630, PMCID: PMC10699704, DOI: 10.1016/j.imj.2022.09.001.Peer-Reviewed Original ResearchNoncanonical inflammasomeRapid cellular responsesKey cellular regulatorsInnate immune signalingMechanism of activationAdaptor proteinCellular regulatorsPattern recognition receptorsNon-canonical inflammasomeImmune signalingCaspase-4Cellular responsesRecognition receptorsSubsequent maturationNegative bacterial infectionsCaspase-1Inflammatory cytokinesInflammatory diseasesInflammasomeBacterial infectionsRecent advancesDiseaseSignalingRegulatorProteinLipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes
Yu X, Tong L, Zhang L, Yang Y, Xiao X, Zhu Y, Wang P, Cheng G. Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes. PLOS Pathogens 2022, 18: e1010552. PMID: 35679229, PMCID: PMC9182268, DOI: 10.1371/journal.ppat.1010552.Peer-Reviewed Original ResearchConceptsJapanese encephalitis virusYellow fever virusZika virusDengue virusSindbis virusGlobal public healthBroad-spectrum virucidal activityEffective prophylacticLipase activityViral envelope structureViral infectionSevere human diseasesEncephalitis virusAedes aegypti midgutVirucidal activityEtiological agentTremendous burdenFever virusVirusMost arbovirusesPublic healthVector-borne diseasesAegypti midgutDiseaseVirucidal ability
2021
Mitofusin‐2 regulates leukocyte adhesion through the maturation of β2 integrin activation in differentiation
Fan Z, Liu W, Wang Y, Hsu A, Lin T, Sun H, Pachter J, Groisman A, Imperioli M, Yungher F, Hu L, Wang P, Deng Q. Mitofusin‐2 regulates leukocyte adhesion through the maturation of β2 integrin activation in differentiation. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.00211.Peer-Reviewed Original ResearchΒ2 integrin activationNeutrophil adhesionLeukocyte adhesionMitofusin 2HL60 cellsIntegrin activationNeutrophil recruitmentNeutrophil-like HL60 cellsVascular endotheliumFMLP receptorInnate immunityReduced expressionΒ2 integrinsConformational specific antibodiesMitofusin 2 deficiencyActivationCellsMaturationCD35InflammationNeutrophilsEndotheliumDiseaseΒ2Immunity
2019
Progress towards Understanding the Mosquito-Borne Virus Life Cycle
Yu X, Zhu Y, Xiao X, Wang P, Cheng G. Progress towards Understanding the Mosquito-Borne Virus Life Cycle. Trends In Parasitology 2019, 35: 1009-1017. PMID: 31669148, DOI: 10.1016/j.pt.2019.09.006.Peer-Reviewed Original ResearchArbovirus lifecycle in mosquito: acquisition, propagation and transmission
Wu P, Yu X, Wang P, Cheng G. Arbovirus lifecycle in mosquito: acquisition, propagation and transmission. Expert Reviews In Molecular Medicine 2019, 21: e1. PMID: 30862324, DOI: 10.1017/erm.2018.6.Peer-Reviewed Original ResearchConceptsDistinct host environmentsBlood mealHaematophagous vectorsVertebrate animalsVertebrate hostsMosquito-Borne VirusesHuman diseasesNaive mosquitoesHost environmentMosquito tissuesNext blood mealInfected hostVector factorsMosquitoesPathogenic virusesHostVirus reservoirVirus survivalRecent studiesAetiological agentVirusTissueMealDiseaseGenetic Determinants of the Re-Emergence of Arboviral Diseases
Ketkar H, Herman D, Wang P. Genetic Determinants of the Re-Emergence of Arboviral Diseases. Viruses 2019, 11: 150. PMID: 30759739, PMCID: PMC6410223, DOI: 10.3390/v11020150.Peer-Reviewed Original ResearchConceptsViral genetic determinantsPublic health threatGenetic determinantsZika virusViral transmissionInfectious diseasesArboviral diseasesWest NileHealth threatYellow feverDiseaseViral fitnessViral geneticsVector competenceInternational travelVirusMosquitoesGlobal climate changeMosquito populationsFeverHost
2017
Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
Sze A, Olagnier D, Hadj SB, Han X, Tian XH, Xu HT, Yang L, Shi Q, Wang P, Wainberg MA, Wu JH, Lin R. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses 2017, 9: 287. PMID: 28972551, PMCID: PMC5691638, DOI: 10.3390/v9100287.Peer-Reviewed Original ResearchConceptsZika virus infectionHepatitis C virusHepatitis C replicationPost-infection treatmentGlobal health concernAntiviral treatmentC virusVirus infectionVesicular stomatitis virusZika virusAntiviral compoundsHealth concernChinese medicinePolymerase inhibitionDengueStomatitis virusVirusTreatmentRNA polymerase inhibitionInfectionDiseaseFlaviviruses
2016
Exploration of West Nile Virus Infection in Mouse Models
Wang P. Exploration of West Nile Virus Infection in Mouse Models. Methods In Molecular Biology 2016, 1435: 71-81. PMID: 27188551, DOI: 10.1007/978-1-4939-3670-0_7.Peer-Reviewed Original ResearchConceptsWest Nile virusMouse modelWest Nile virus infectionExperimental mouse modelAntiviral immune responseCentral nervous systemWNV pathogenesisLeukocyte numbersVirus infectionImmune responseBlood leukocytesWNV infectionNervous systemNeurological diseasesMouse brainViral titersResidential cellsLeukocytesNile virusVirus spreadInfectionImmunopathologyPathogenesisCNSDisease
2015
Mosquito Defense Strategies against Viral Infection
Cheng G, Liu Y, Wang P, Xiao X. Mosquito Defense Strategies against Viral Infection. Trends In Parasitology 2015, 32: 177-186. PMID: 26626596, PMCID: PMC4767563, DOI: 10.1016/j.pt.2015.09.009.Peer-Reviewed Original ResearchConceptsViral infectionMosquito antiviral immunityEfficient antiviral strategiesPathological sequelaePersistent infectionAntiviral immunityArbovirus infectionViral replicationAntiviral strategiesInfectionMosquito tissuesViral diseasesGlobal healthViral propagationMosquitoesTissueNatural vectorSequelaeSpecific tissuesDiseaseImmunity
2011
prM-antibody renders immature West Nile virus infectious in vivo
Colpitts TM, Rodenhuis-Zybert I, Moesker B, Wang P, Fikrig E, Smit JM. prM-antibody renders immature West Nile virus infectious in vivo. Journal Of General Virology 2011, 92: 2281-2285. PMID: 21697345, PMCID: PMC3347797, DOI: 10.1099/vir.0.031427-0.Peer-Reviewed Original ResearchConceptsWest Nile virusInfectious West Nile virusNile virusDeath of micePrM antibodiesNeurotropic pathogensWNV particlesSevere human diseasesFamily FlaviviridaeVivo proofImmature flavivirus particlesInfectious potentialAntibodiesDiseaseViral surfaceVirus particlesPrM proteinFlavivirus particlesVirusHuman diseasesInfectionMiceFlavivirusesBrainSerum
2007
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis
Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. Journal Of Experimental Medicine 2007, 205: 133-141. PMID: 18166585, PMCID: PMC2234379, DOI: 10.1084/jem.20070962.Peer-Reviewed Original ResearchConceptsLyme arthritisMouse jointsB. burgdorferi antigensBurgdorferi-infected miceSevere arthritisSpirochete numbersArthritisHost responseLyme diseaseAffinity-purified antibodiesBorrelia burgdorferiChain reactionMiceOriginal phenotypeBasic membrane proteinMutant spirochetesGene expressionJointsInflammationPathogenesisAntigenDiseaseB. burgdorferi gene expression