2024
Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations.
Niu N, Buza N, Hui P. Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations. International Journal Of Gynecological Pathology 2024 PMID: 38959396, DOI: 10.1097/pgp.0000000000001044.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorEpithelioid trophoblastic tumorSerum human chorionic gonadotropinHuman chorionic gonadotropinTrophoblastic tumorImmune checkpoint inhibitor therapyActinomycin D therapyMethotrexate-based chemotherapyVariable clinicopathological presentationsCheckpoint inhibitor therapyGestational trophoblastic tumorsSerum hCG levelsExtrauterine metastasesMultiagent chemotherapyVaginal bleedingHCG levelsHydatidiform moleInhibitor therapyCervical massUterine massGestational originEndometrial biopsyClinicopathological presentationPatient ageDisease-freeDiandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction?
Nagy A, Niu N, Sun T, Buza N, Hui P. Diandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction? Histopathology 2024, 85: 879-888. PMID: 39031756, DOI: 10.1111/his.15247.Peer-Reviewed Original ResearchPositive predictive valueTriploid gestationsPartial moleTrophoblastic hyperplasiaVillous sizeCistern formationHistological parametersPostmolar gestational trophoblastic neoplasiaTriploid partial molesGenotype-phenotype correlation studiesGestational trophoblastic neoplasiaPartial hydatidiform moleModerate interobserver agreementVillous populationsTrophoblastic neoplasiaGestational weeksHydatidiform moleClinical presentationPatient ageDigynic triploidyAbnormal histologyInterobserver agreementGestationSyncytiotrophoblastHistological assessment
2020
Lack of genetic homozygosity in prepubertal teratomas: divergent pathogenesis distinct from that of teratomas in adolescents
Snir OL, DeJoseph M, Wu X, Rottmann D, Wong S, Buza N, Hui P. Lack of genetic homozygosity in prepubertal teratomas: divergent pathogenesis distinct from that of teratomas in adolescents. Laboratory Investigation 2020, 100: 1447-1454. PMID: 32694569, DOI: 10.1038/s41374-020-0468-6.Peer-Reviewed Original ResearchConceptsOvarian teratomaPatient ageImmature teratomaTesticular teratomaMature teratomaSacrococcygeal teratomaMixed germ cell tumorGerm cell tumorsMature ovarian teratomaChildren 18 yearsDivergent pathogenesisGenetic zygosityPrepubertal teratomasCell tumorsGonadal teratomaTeratomaGenetic homozygosityNormal tissuesPatientsGerm cell developmentSacrococcygealAgeCell developmentDepartmental archivesGerm cells
2015
Intravenous Leiomyomatosis Revisited
Carr RJ, Hui P, Buza N. Intravenous Leiomyomatosis Revisited. International Journal Of Gynecological Pathology 2015, 34: 169-176. PMID: 25675187, DOI: 10.1097/pgp.0000000000000127.Peer-Reviewed Original ResearchConceptsIntravenous leiomyomatosisSmooth muscle originMuscle originCases of IVLCommon extrauterine siteRight heart chambersGood overall prognosisPatients' medical recordsDirect mass effectGross pathologic findingsConventional diagnostic criteriaExtrauterine extensionExtrauterine involvementClinical sequelaeOverall prognosisDisease recurrenceMedian agePatient agePrompt diagnosisInitial diagnosisPathologic findingsSignificant morbiditySurgical excisionInferior venaPrimary lesion
2014
Mitotically Active Microglandular Hyperplasia of the Cervix
Abi-Raad R, Alomari A, Hui P, Buza N. Mitotically Active Microglandular Hyperplasia of the Cervix. International Journal Of Gynecological Pathology 2014, 33: 524-530. PMID: 25083971, DOI: 10.1097/pgp.0000000000000086.Peer-Reviewed Original ResearchConceptsHuman papillomavirus (HPV) statusMicroglandular hyperplasiaSmall biopsy specimensEndometrial malignancyClinical historyBiopsy specimensHigh risk human papillomavirus statusCarcinoembryonic antigenKi-67 proliferation indexMitotic activityModerate nuclear atypiaPatient's clinical historySignet ring cellsSignificant mitotic activityReticular growth patternMicroglandular patternVimentin immunostainsPatient ageCase seriesEndocervical polypEndometrial adenocarcinomaEndocervical glandsDiagnostic dilemmaClinical prognosisMucinous differentiationGenotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament
Buza N, Rutherford T, Hui P. Genotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament. International Journal Of Gynecological Pathology 2014, 33: 58-63. PMID: 24300537, DOI: 10.1097/pgp.0b013e31827cd386.Peer-Reviewed Original ResearchConceptsBroad ligamentFallopian tubePelvic lymph node metastasisMultiagent chemotherapy regimenRecurrence 26 monthsRight adnexal massRight fallopian tubeLymph node metastasisOnly necrotic tissueLast menstrual periodLarge tumor massMicroscopic examinationChemotherapy regimenEctopic pregnancyMultiagent chemotherapyNongestational choriocarcinomaPure choriocarcinomaNode metastasisPatient ageInitial diagnosisInitial presentationGestational choriocarcinomaAdnexal massesFinal diagnosisEmergency room
2008
High grade cervical intraepithelial neoplasia and viral load of high-risk human papillomavirus: significant correlations in patients of 22 years old or younger.
Xu Y, Dotto J, Hui Y, Lawton K, Schofield K, Hui P. High grade cervical intraepithelial neoplasia and viral load of high-risk human papillomavirus: significant correlations in patients of 22 years old or younger. International Journal Of Clinical And Experimental Pathology 2008, 2: 169-75. PMID: 19079652, PMCID: PMC2583634.Peer-Reviewed Original ResearchHigh viral loadHigh-grade squamous intraepithelial lesionsHigh-risk human papillomavirusSquamous intraepithelial lesionsViral loadHR-HPVHPV loadIntraepithelial lesionsHistological gradeHuman papillomavirusHigh-grade cervical intraepithelial neoplasiaHigh-grade cervical dysplasiaGrade squamous intraepithelial lesionHigh HPV loadHR-HPV testingAssociation of HPVCervical intraepithelial neoplasiaHigh-grade dysplasiaLow-grade dysplasiaViral load dataLogistic regression analysisAge-dependent mannerPatient ageCervical dysplasiaCervical biopsies