2019
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease
Sun Q, Lee W, Mohri Y, Takeo M, Lim CH, Xu X, Myung P, Atit RP, Taketo MM, Moubarak RS, Schober M, Osman I, Gay DL, Saur D, Nishimura EK, Ito M. A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease. Nature Communications 2019, 10: 5023. PMID: 31685822, PMCID: PMC6828673, DOI: 10.1038/s41467-019-12733-1.Peer-Reviewed Original ResearchConceptsMouse modelNovel mouse modelMelanoma progression modelDeadly skin cancerAnimal modelsSkin cancerBona fide sourceAdvanced stageMelanoma inductionMalignant transformationHuman melanomaMelanomaGene signatureAnagen onsetMolecular profilingMelanoma initiationMelanocyte stem cellsNormal WntStem cellsProgression modelHuman diseasesRecent studiesCancerDiseaseProgression
2001
Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength
Izon D, Punt J, Xu L, Karnell F, Allman D, Myung P, Boerth N, Pui J, Koretzky G, Pear W. Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength. Immunity 2001, 14: 253-264. PMID: 11290335, DOI: 10.1016/s1074-7613(01)00107-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD5 AntigensCD8-Positive T-LymphocytesCell DifferentiationDNA-Binding ProteinsFlow CytometryGene Expression RegulationHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansJurkat CellsLectins, C-TypeLiverMembrane ProteinsMiceMice, TransgenicNFATC Transcription FactorsNuclear ProteinsPromoter Regions, GeneticReceptor, Notch1Receptors, Antigen, T-CellReceptors, Cell SurfaceResponse ElementsSignal TransductionThymus GlandTranscription Factor AP-1Transcription FactorsConceptsTCR signal strengthCell fate decisionsJurkat T cellsTCR-mediated signalingT cell developmentFate decisionsMultiple lineagesNotch signalingDevelopmental arrestCell developmentNotch expressionThymocyte developmentTCR stimulationRetroviral expressionT cellsPhysiological regulationSingle-positive T cellsTCR transgenic thymocytesDifferentiation of immatureTransgenic thymocytesNotch1Maturation of CD4SignalingMouse thymocytesThymocytes
1999
Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide.
Cowdery J, Boerth N, Norian L, Myung P, Koretzky G. Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide. The Journal Of Immunology 1999, 162: 6770-5. PMID: 10352297, DOI: 10.4049/jimmunol.162.11.6770.Peer-Reviewed Original Research