2004
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function* [boxs]
Singer AL, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA. Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function* [boxs]. Journal Of Biological Chemistry 2004, 279: 15481-15490. PMID: 14722089, DOI: 10.1074/jbc.m313339200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlanineAntigens, CDAntigens, Differentiation, T-LymphocyteArginineBlotting, WesternCalciumCell LineCell LineageFlow CytometryGene DeletionGenes, DominantHematopoietic Stem CellsHumansJurkat CellsLectins, C-TypeLuciferasesLymphocyte ActivationLysineMembrane MicrodomainsModels, BiologicalMutationPhosphoproteinsPlasmidsPrecipitin TestsProlineProtein Structure, TertiarySignal TransductionSrc Homology DomainsSubcellular FractionsTime FactorsT-LymphocytesTransfectionConceptsSLP-76P1 domainSLP-76 functionProline-rich domainProline-rich regionDomain deletion mutantMultiple hematopoietic lineagesLeukocyte-specific phosphoproteinSrc homologyDeletion mutantsSignal transductionSubcellular localizationHematopoietic lineagesFunctional roleProtein fragmentsT cell receptorMolecular scaffoldsCell functionCell receptorLocalizationComplementary approachesDomainT cell functionMolecular associationDirect evidence
2003
Inhibition of T cell activation through interruption of adaptor protein associations
Singer A, Bunnell S, Obstfeld A, Jordan M, Wu J, Myung P, Samelson L, Koretzky G. Inhibition of T cell activation through interruption of adaptor protein associations. Journal Of Surgical Research 2003, 114: 271. DOI: 10.1016/j.jss.2003.08.227.Peer-Reviewed Original ResearchSLP-76NF-ATSLP-76 functionTCR engagementT cell receptorMultiple hematopoietic lineagesLive confocal microscopyJurkat T cellsAdaptor LATInducible associationSecond messenger pathwaysBinding partnerComplex assemblyProtein associationBiochemical signalsHematopoietic lineagesAdaptor moleculeFusion proteinImmune synapseTCR stimulationJurkat cellsMessenger pathwaysCell membraneT cell activationBinding fragment
2001
Coupling of the TCR to Integrin Activation by SLAP-130/Fyb
Peterson E, Woods M, Dmowski S, Derimanov G, Jordan M, Wu J, Myung P, Liu Q, Pribila J, Freedman B, Shimizu Y, Koretzky G. Coupling of the TCR to Integrin Activation by SLAP-130/Fyb. Science 2001, 293: 2263-2265. PMID: 11567141, DOI: 10.1126/science.1063486.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdaptor Proteins, Signal TransducingAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell AdhesionCell MembraneImmunologic CappingIntercellular Adhesion Molecule-1Interleukin-2Lectins, C-TypeLymphocyte ActivationLymphocyte Function-Associated Antigen-1MicePhosphatidylinositol 3-KinasesPhosphoproteinsProtein-Tyrosine KinasesReceptors, Antigen, T-CellReceptors, Interleukin-2Signal TransductionT-Lymphocytes