2003
Inhibition of T cell activation through interruption of adaptor protein associations
Singer A, Bunnell S, Obstfeld A, Jordan M, Wu J, Myung P, Samelson L, Koretzky G. Inhibition of T cell activation through interruption of adaptor protein associations. Journal Of Surgical Research 2003, 114: 271. DOI: 10.1016/j.jss.2003.08.227.Peer-Reviewed Original ResearchSLP-76NF-ATSLP-76 functionTCR engagementT cell receptorMultiple hematopoietic lineagesLive confocal microscopyJurkat T cellsAdaptor LATInducible associationSecond messenger pathwaysBinding partnerComplex assemblyProtein associationBiochemical signalsHematopoietic lineagesAdaptor moleculeFusion proteinImmune synapseTCR stimulationJurkat cellsMessenger pathwaysCell membraneT cell activationBinding fragmentSignaling Via the T Cell Receptor
Singer A, Jordan M, Judd B, Myung P, Newbrough S, Nichols K, Olenchock B, Peterson E, Wu J, Zhong X, Koretzky G. Signaling Via the T Cell Receptor. Science Signaling 2003, 2003 DOI: 10.1126/stke.2003.194.cm7.Peer-Reviewed Original ResearchRas-mitogen-activated protein kinaseSrc homology 2 domainPhospholipase C-γ1 activationT cell signal transductionProtein kinase C θCell signal transductionT cell activationT cell receptor engagementTranscription factor nuclear factorCell receptor engagementRas guanineSLP-76Cytoplasmic domainSignal transductionSrc familyProtein kinaseActivation motifCell activationDownstream targetsMAP pathwayCleavage of phosphatidylinositolNegative regulatorGene expressionProximal regulatorSecond messenger
2001
Positive and negative regulation of t-cell activation by adaptor proteins
Koretzky G, Myung P. Positive and negative regulation of t-cell activation by adaptor proteins. Nature Reviews Immunology 2001, 1: 95-107. PMID: 11905825, DOI: 10.1038/35100523.Peer-Reviewed Original ResearchConceptsEffector protein activityPost-translational modificationsSrc family kinasesAdaptor domainsAdaptor proteinSH3 domainFamily kinasesSubcellular localizationGenetic manipulationNegative regulationProtein activityNegative regulatorAdaptorEffector moleculesT cell activationCell linesSpatial organizationRegulatorProteinIntramolecular interactionsLymphocyte activationSH2ActivationKinaseComplexes