2005
AP2α alters the transcriptional activity and stability of p53
Stabach P, Thiyagarajan M, Woodfield G, Weigel R. AP2α alters the transcriptional activity and stability of p53. Oncogene 2005, 25: 2148-2159. PMID: 16288208, DOI: 10.1038/sj.onc.1209250.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsChromatin ImmunoprecipitationColonic NeoplasmsCyclin-Dependent Kinase Inhibitor p21Gene Expression Regulation, NeoplasticGenes, ReporterHumansImmunoprecipitationLiver NeoplasmsPoint MutationPromoter Regions, GeneticProtein BindingTranscription Factor AP-2Transcription, GeneticTranscriptional ActivationTumor Cells, CulturedTumor Suppressor Protein p53ConceptsTranscriptional activityEndogenous p53 target genesEndogenous p21 geneNormal transcriptional activityP53 target genesP53-mediated inductionAmino acids 305Stability of p53Expression of aP2Transcriptional coactivationP21WAF1/CIP1P21 promoterTarget genesCertain genesRegion of p53AP2αReporter assaysP21 geneFunctional partnershipP53 stabilityP53 activityCell growthPoint mutationsAP2Genes
2000
Identification and Characterization of βV Spectrin, a Mammalian Ortholog of Drosophila βHSpectrin* 210
Stabach P, Morrow J. Identification and Characterization of βV Spectrin, a Mammalian Ortholog of Drosophila βHSpectrin* 210. Journal Of Biological Chemistry 2000, 275: 21385-21395. PMID: 10764729, DOI: 10.1074/jbc.c000159200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCaenorhabditis elegansCloning, MolecularConsensus SequenceDNA, ComplementaryDrosophilaDrosophila ProteinsExonsGene LibraryHumansIntronsMammalsMolecular Sequence DataMolecular WeightOrgan SpecificityPhylogenyRatsRecombinant ProteinsRepetitive Sequences, Amino AcidRetinaSequence AlignmentSequence Homology, Amino AcidSpectrinTumor Cells, CulturedViral ProteinsConceptsDrosophila orthologMammalian orthologsSpectrin repeatsPleckstrin homology domainComplete cDNA sequenceActin-binding domainSelf-association domainAmino acids 85Amino acid sequenceBeta-spectrin geneHuman retina cDNA libraryRetina cDNA libraryFly counterpartMammalian spectrinsCaenorhabditis elegansHomology domainEpithelial cell populationsSH3 domainApical domainCDNA sequenceCDNA libraryOrthologsPolarized epitheliumBeta spectrinAcid sequence