2017
Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases
Luo M, Flood EC, Almeida D, Yan L, Berlin DA, Heerdt PM, Hajjar KA. Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases. Journal Of Experimental Medicine 2017, 214: 2535-2545. PMID: 28694388, PMCID: PMC5584111, DOI: 10.1084/jem.20160652.Peer-Reviewed Original ResearchConceptsAlveolar hypoxiaVascular endothelial cadherinMicrovascular integrityPulmonary edemaSrc homology phosphatase 2Vascular integrityEndothelial cellsVascular endothelial growth factorMicrovascular endothelial cellsEndothelial growth factorAdherens junction protein vascular endothelial cadherinEndothelial cadherinAirway obstructionNeutrophil infiltrationPulmonary microvasculatureAnnexin A2 functionsVascular leakLung parenchymaMice displayAltitude sicknessBarrier functionGrowth factorHypoxiaPhospholipid-binding proteinsProtein tyrosine phosphataseSingle-lung ventilation and oxidative stress
Heerdt PM, Stowe DF. Single-lung ventilation and oxidative stress. Current Opinion In Anaesthesiology 2017, 30: 42-49. PMID: 27783023, DOI: 10.1097/aco.0000000000000410.Peer-Reviewed Original ResearchConceptsSingle-lung ventilationOxidative stressRe-expanded lungHypoxic pulmonary vasoconstrictionRedistribution of bloodLocal tissue hypoxiaPostoperative disruptionPulmonary vasoconstrictionReperfusion responseAtelectatic lungTissue hypoxiaClinical dataReactive oxygenSystemic effectsOrgan functionLungNitrosative stressVentilationNitrogen speciesVasoconstriction
2010
Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ. Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs. Anesthesiology 2010, 112: 910-916. PMID: 20234311, DOI: 10.1097/aln.0b013e3181d31f71.Peer-Reviewed Original ResearchConceptsX ED95Neuromuscular blocking drugsCardiopulmonary side effectsVascular resistanceArterial pressureBlocking drugsCardiac outputHistamine releaseSide effectsMean pulmonary artery pressurePulmonary artery pressurePulmonary vascular resistanceSystemic vascular resistanceMean arterial pressurePulmonary arterial pressureArtery pressureHemodynamic effectsPulmonary complianceVentricular contractilityInspiratory pressureNeuromuscular blockadeVentricular pressureED95Large dosesCW002
2009
Postoperative care after pulmonary resection: postanesthesia care unit versus intensive care unit
Pedoto A, Heerdt PM. Postoperative care after pulmonary resection: postanesthesia care unit versus intensive care unit. Current Opinion In Anaesthesiology 2009, 22: 50. PMID: 19295292, DOI: 10.1097/aco.0b013e32831d7b25.Peer-Reviewed Original ResearchConceptsLength of stayElective lung resectionPostanesthesia care unitLung resectionCare unitPostoperative careElective ICU admissionSevere postoperative complicationsHigh-risk patientsImmediate postoperative careNoncardiac thoracic surgeryIntensive care unitPerioperative patient careComplex surgical casesPostoperative areaICU admissionPostoperative complicationsPulmonary resectionPreoperative evaluationAnesthetic techniqueOptimal careLung cancerThoracic surgeryHospital costsSurgical cases
2007
Nitrosative Stress and Myocardial Sarcoplasmic Endoreticular Calcium Adenosine Triphosphatase Subtype 2a Activity after Lung Resection in Swine
Heerdt PM, Lane P, Pan BY, Schaefer U, Crabtree M, Hong R, Singer AA, Levi R, Park BJ. Nitrosative Stress and Myocardial Sarcoplasmic Endoreticular Calcium Adenosine Triphosphatase Subtype 2a Activity after Lung Resection in Swine. Anesthesiology 2007, 107: 954-962. PMID: 18043064, DOI: 10.1097/01.anes.0000291446.70921.61.Peer-Reviewed Original ResearchConceptsNitrosative stressForce-frequency relationLung resectionSERCA2a activityAcute oxidative stressOxidative stressPhosphorylation stateSubcellular processesBiochemical basisProtein phospholambanDisease-associated oxidative stressRegulatory protein phospholambanPhospholamban phosphorylationReticular membranesProtein expressionImpaired calcium cyclingPhosphorylationWestern blottingExpressionPerioperative changesUpper lobectomyPhospholamban expressionSham groupAcute eventChronic illnessPulmonary resection in the elderly
Castillo MD, Heerdt PM. Pulmonary resection in the elderly. Current Opinion In Anaesthesiology 2007, 20: 4-9. PMID: 17211159, DOI: 10.1097/aco.0b013e32801271fa.Peer-Reviewed Original ResearchConceptsElderly patientsLung resectionPulmonary resectionOncologic efficacyLung cancerSurgical techniquePreoperative functional statusHealthy elderly patientsLung cancer populationRisk-benefit relationshipInvasive surgical techniquesNeoadjuvant therapyPerioperative morbiditySurgical therapyPerioperative stressPreoperative interventionConventional thoracotomySurgical managementPalliative carePoor prognosisTumor stageCancer populationFunctional statusGeriatric populationPhysiological reserve
2006
Systemic oxidative stress associated with lung resection during single lung ventilation
Heerdt PM, Lane PB, Crabtree MJ, Park BJ. Systemic oxidative stress associated with lung resection during single lung ventilation. European Journal Of Cardio-Thoracic Surgery 2006, 30: 568-569. PMID: 16857372, DOI: 10.1016/j.ejcts.2006.05.022.Peer-Reviewed Original Research
2004
Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs
Heerdt PM, Kang R, The’ A, Hashim M, Mook RJ, Savarese JJ. Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs. Anesthesiology 2004, 100: 846-851. PMID: 15087619, DOI: 10.1097/00000542-200404000-00014.Peer-Reviewed Original ResearchConceptsX ED95Cardiopulmonary changesBolus dosingDirect myocardial depressionStable neuromuscular blockadeMean arterial pressurePlasma histamine concentrationCardiopulmonary side effectsNondepolarizing neuromuscularPulmonary vasoconstrictionArterial pressureCardiovascular effectsMyocardial depressionCardiopulmonary effectsHemodynamic measurementsInspiratory pressureNeuromuscular blockadePulmonary complianceAnesthetized dogsCardiopulmonary dataMale beaglesArterial bloodED95Heart rateSide effects
2001
Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure
Barbone A, Holmes J, Heerdt P, The’ A, Naka Y, Joshi N, Daines M, Marks A, Oz M, Burkhoff D. Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure. Circulation 2001, 104: 670-675. PMID: 11489773, DOI: 10.1161/hc3101.093903.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBlood PressureCalcium-Transporting ATPasesCardiac OutputFemaleFibrosisHeart FailureHeart TransplantationHeart VentriclesHeart-Assist DevicesHemodynamicsHumansIn Vitro TechniquesLungMaleMiddle AgedSarcoplasmic Reticulum Calcium-Transporting ATPasesTime FactorsVenous PressureConceptsSevere heart failureLVAD supportRight ventricleLeft ventricleReverse remodelingHeart failureHigh central venous pressurePulmonary artery diastolic pressureVentricular assist device supportLV myocyte diameterCentral venous pressureAssist device supportHigh cardiac outputHearts of patientsForce-frequency relationVentricular assist deviceComparison of rightPossible primary roleRV trabeculaeVenous pressureVentricular responseDiastolic pressureHemodynamic unloadingCardiac outputNeurohormonal factors
1998
Intrapulmonary shunt fraction and prostaglandin E1.
Heerdt P. Intrapulmonary shunt fraction and prostaglandin E1. Anesthesia & Analgesia 1998, 87: 233. PMID: 9661585, DOI: 10.1097/00000539-199807000-00055.Peer-Reviewed Original ResearchIntrapulmonary Shunt Fraction and Prostaglandin E1
Heerdt P. Intrapulmonary Shunt Fraction and Prostaglandin E1. Anesthesia & Analgesia 1998, 87: 233.. DOI: 10.1213/00000539-199807000-00055.Peer-Reviewed Original Research