2012
Anesthesia and Pulmonary Hypertension
McGlothlin D, Ivascu N, Heerdt PM. Anesthesia and Pulmonary Hypertension. Progress In Cardiovascular Diseases 2012, 55: 199-217. PMID: 23009916, DOI: 10.1016/j.pcad.2012.08.002.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionNon-cardiothoracic surgeryThorough multidisciplinary planningOperative risk factorsRight ventricular failurePulmonary arterial hypertensionPreoperative risk assessmentCareful intraoperative managementArterial hypertensionPostoperative complicationsPostoperative hypoxemiaVentricular failureCardiac surgeryIntraoperative managementAnesthetic approachEarly recognitionMyocardial ischemiaRisk factorsMultidisciplinary planningHypertensionPatientsSurgerySuccessful managementAnesthesiaHypoxemia
2008
Activation of brain protein phosphatase‐1I following cardiac arrest and resuscitation involving an interaction with 14‐3‐3γ
Platholi J, Heerdt PM, Tung H, Hemmings HC. Activation of brain protein phosphatase‐1I following cardiac arrest and resuscitation involving an interaction with 14‐3‐3γ. Journal Of Neurochemistry 2008, 105: 2029-2038. PMID: 18284617, PMCID: PMC3872065, DOI: 10.1111/j.1471-4159.2008.05300.x.Peer-Reviewed Original ResearchConceptsGlobal cerebral ischemiaCerebral ischemiaCardiac arrestTransient global cerebral ischemiaTransient cerebral ischemiaPotential therapeutic targetRelevant pig modelIschemic brainNeuroprotective mechanismsControl brainsInhibitory modulatorTherapeutic targetPig modelIschemiaPig brainBrain proteinsMechanism-based approachBrainProtein betaResuscitationEnergy metabolismCritical regulatorArrestVivoActivationProtein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation
Zhang TT, Platholi J, Heerdt PM, Hemmings HC, Tung HY. Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation. Metabolic Brain Disease 2008, 23: 95-104. PMID: 18197471, DOI: 10.1007/s11011-007-9074-1.Peer-Reviewed Original Research