2011
Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles
Heerdt PM, Wagner CL, DeMais M, Savarese JJ. Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles. Journal Of Pharmacological And Toxicological Methods 2011, 64: 111-118. PMID: 21440649, DOI: 10.1016/j.vascn.2011.03.006.Peer-Reviewed Original ResearchConceptsCardiac outputAortic blood flowDrug-induced changesBlood flowAcute drug-induced changesNoninvasive cardiac output monitoringNon-invasive measurementOpen-chest beaglesNeuromuscular blocking drugsPreclinical drug evaluationCardiac output monitoringDrug evaluation studiesML/minSimultaneous CO measurementsBlocking drugsAcute alterationsAortic rootPreclinical screeningChest instrumentationNICOMCO measurementsOutput monitoringDrug evaluationInvasive measurementsInvasive instrumentation
2010
Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ. Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs. Anesthesiology 2010, 112: 910-916. PMID: 20234311, DOI: 10.1097/aln.0b013e3181d31f71.Peer-Reviewed Original ResearchConceptsX ED95Neuromuscular blocking drugsCardiopulmonary side effectsVascular resistanceArterial pressureBlocking drugsCardiac outputHistamine releaseSide effectsMean pulmonary artery pressurePulmonary artery pressurePulmonary vascular resistanceSystemic vascular resistanceMean arterial pressurePulmonary arterial pressureArtery pressureHemodynamic effectsPulmonary complianceVentricular contractilityInspiratory pressureNeuromuscular blockadeVentricular pressureED95Large dosesCW002Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs
Sunaga H, Malhotra JK, Yoon E, Savarese JJ, Heerdt PM. Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs. Anesthesiology 2010, 112: 900-909. PMID: 20234310, DOI: 10.1097/aln.0b013e3181d31f8c.Peer-Reviewed Original ResearchConceptsOrgan toxicityHeart rateIsoflurane-nitrous oxide anesthesiaAcute cardiovascular effectsNeuromuscular blocking drugsDose-response relationshipDose-dependent mannerEndogenous L-cysteineCardiovascular effectsHemodynamic effectsMedian durationArterial pressureBlood pressureBlocking drugsHistologic evidenceNeuromuscular blockadeOxide anesthesiaTwitch recoveryMuscle recoveryHistopathologic analysisMuscle twitchLarge doseCW002Additional groupDose
2004
Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs
Heerdt PM, Kang R, The’ A, Hashim M, Mook RJ, Savarese JJ. Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs. Anesthesiology 2004, 100: 846-851. PMID: 15087619, DOI: 10.1097/00000542-200404000-00014.Peer-Reviewed Original ResearchConceptsX ED95Cardiopulmonary changesBolus dosingDirect myocardial depressionStable neuromuscular blockadeMean arterial pressurePlasma histamine concentrationCardiopulmonary side effectsNondepolarizing neuromuscularPulmonary vasoconstrictionArterial pressureCardiovascular effectsMyocardial depressionCardiopulmonary effectsHemodynamic measurementsInspiratory pressureNeuromuscular blockadePulmonary complianceAnesthetized dogsCardiopulmonary dataMale beaglesArterial bloodED95Heart rateSide effects
2001
Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation
Heerdt P, Blessios G, Beach M, Hogue C. Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation. Journal Of Cardiothoracic And Vascular Anesthesia 2001, 15: 183-187. PMID: 11312476, DOI: 10.1053/jcan.2001.21947.Peer-Reviewed Original ResearchConceptsAcute tricuspid regurgitationTricuspid regurgitationCardiac outputArteriovenous shuntsSevere regurgitationVenous returnPeripheral arteriovenous shuntsSevere tricuspid regurgitationThermodilution cardiac output measurementsAnesthetized mongrel dogsThermodilution cardiac outputCardiac output measurementsElectromagnetic flowMongrel dogsRegurgitationAnimal studiesThermodilution measurementsShuntThermodilutionVariable degreesMinimal effectMin
2000
Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model
Blanck T, Haile M, Xu F, Zhang J, Heerdt P, Veselis R, Beckman J, Kang R, Adamo A, Hemmings H. Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model. Anesthesiology 2000, 93: 1285-1293. PMID: 11046218, DOI: 10.1097/00000542-200011000-00023.Peer-Reviewed Original ResearchMeSH KeywordsAnesthetics, InhalationAnimalsBlood PressureBlotting, WesternBrain DiseasesCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesDogsFemaleHeart Arrest, InducedHeart RateHippocampusIschemic Attack, TransientIschemic PreconditioningIsofluraneNeuroprotective AgentsSynaptosomesConceptsNeurologic deficit scoreCanine cardiac arrest modelCardiac arrest modelDeficit scoresIschemic animalsCardiac arrestGlobal ischemiaStriatum of animalsEffective neuroprotective drugsIsoflurane pretreatmentNeurologic dysfunctionNeurologic functionHippocampal contentNeuroprotective effectsIsoflurane exposureHippocampal levelsIntensive careNeuroprotective drugsRat modelVentricular fibrillationInhalational anestheticsTreatment groupsBlinded evaluatorsCanine modelIschemia
1992
Comparison of cardiac output measured by intrapulmonary artery doppler, thermodilution, and electromagnetometry
Heerdt P, Pond C, Blessios G, Rosenbloom M. Comparison of cardiac output measured by intrapulmonary artery doppler, thermodilution, and electromagnetometry. The Annals Of Thoracic Surgery 1992, 54: 959-966. PMID: 1417293, DOI: 10.1016/0003-4975(92)90660-v.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassCardiac outputElective coronary artery bypassIntrapulmonary artery DopplerCardiac surgical patientsCoronary artery bypassCardiac output measurementsArtery DopplerArtery bypassSurgical patientsCatheter withdrawalCatheter systemThermodilutionBypassPatientsDoppler transducerMedian absolute errorModerate correlationPresent studyEM flowElectromagnetic flowDecannulationAortaMalposition