2008
The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly
Heerdt PM, Park BJ. The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly. Anesthesiology Clinics 2008, 26: 315-324. PMID: 18456216, DOI: 10.1016/j.anclin.2008.01.009.Peer-Reviewed Original ResearchConceptsPerioperative morbidityEarly-stage lung cancerVideo-assisted thoracoscopic lobectomyLung cancer surgeryInvasive operative techniquesInvasive surgical techniquesElderly patientsPulmonary resectionSurgical therapyLung malignancyPreoperative interventionSurgical treatmentCancer surgeryConventional thoracotomyOncologic efficacyThoracoscopic lobectomyGeriatric populationLung cancerAdvanced ageSurgical techniqueOperative techniqueClear associationEmerging RoleGeneral agingMorbidityPractice Patterns in Choice of Left Double-Lumen Tube Size for Thoracic Surgery
Amar D, Desiderio DP, Heerdt PM, Kolker AC, Zhang H, Thaler HT. Practice Patterns in Choice of Left Double-Lumen Tube Size for Thoracic Surgery. Anesthesia & Analgesia 2008, 106: 379-383. PMID: 18227288, DOI: 10.1213/ane.0b013e3181602e41.Peer-Reviewed Original ResearchConceptsDouble-lumen tubeFr double lumen tubeLung isolationDLT repositioningThoracic surgeryDouble-lumen tube sizeSized double-lumen tubePilot studyIntraoperative outcome measuresLeft mainstem bronchusProspective pilot studyIntraoperative hypoxemiaAirway traumaTransient hypoxemiaFiberoptic bronchoscopyMainstem bronchusIntraoperative outcomesSimilar incidenceBronchial cuffDLT sizePractice patternsOutcome measuresSurgeryHypoxemiaPatients
2007
Inflammation and outcome after general thoracic surgery
Amar D, Zhang H, Park B, Heerdt PM, Fleisher M, Thaler HT. Inflammation and outcome after general thoracic surgery. European Journal Of Cardio-Thoracic Surgery 2007, 32: 431-434. PMID: 17643996, DOI: 10.1016/j.ejcts.2007.06.017.Peer-Reviewed Original ResearchConceptsC-reactive proteinMajor postoperative complicationsPostoperative complicationsIL-6Non-steroidal anti-inflammatory drug useHigh-sensitivity C-reactive proteinAnti-inflammatory drug usePreoperative C-reactive proteinSensitivity C-reactive proteinImportant postoperative complicationPreoperative albumin levelTertiary cancer centerMarkers of inflammationMarkers of outcomePostanesthesia care unitProspective data collectionGeneral thoracic surgeryLung resectionSystemic inflammationAlbumin levelsConsecutive patientsLow albuminCare unitPoor outcomeCancer CenterPulmonary resection in the elderly
Castillo MD, Heerdt PM. Pulmonary resection in the elderly. Current Opinion In Anaesthesiology 2007, 20: 4-9. PMID: 17211159, DOI: 10.1097/aco.0b013e32801271fa.Peer-Reviewed Original ResearchConceptsElderly patientsLung resectionPulmonary resectionOncologic efficacyLung cancerSurgical techniquePreoperative functional statusHealthy elderly patientsLung cancer populationRisk-benefit relationshipInvasive surgical techniquesNeoadjuvant therapyPerioperative morbiditySurgical therapyPerioperative stressPreoperative interventionConventional thoracotomySurgical managementPalliative carePoor prognosisTumor stageCancer populationFunctional statusGeriatric populationPhysiological reserve
2001
Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure
Barbone A, Holmes J, Heerdt P, The’ A, Naka Y, Joshi N, Daines M, Marks A, Oz M, Burkhoff D. Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure. Circulation 2001, 104: 670-675. PMID: 11489773, DOI: 10.1161/hc3101.093903.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBlood PressureCalcium-Transporting ATPasesCardiac OutputFemaleFibrosisHeart FailureHeart TransplantationHeart VentriclesHeart-Assist DevicesHemodynamicsHumansIn Vitro TechniquesLungMaleMiddle AgedSarcoplasmic Reticulum Calcium-Transporting ATPasesTime FactorsVenous PressureConceptsSevere heart failureLVAD supportRight ventricleLeft ventricleReverse remodelingHeart failureHigh central venous pressurePulmonary artery diastolic pressureVentricular assist device supportLV myocyte diameterCentral venous pressureAssist device supportHigh cardiac outputHearts of patientsForce-frequency relationVentricular assist deviceComparison of rightPossible primary roleRV trabeculaeVenous pressureVentricular responseDiastolic pressureHemodynamic unloadingCardiac outputNeurohormonal factors
2000
Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure
Heerdt P, Holmes J, Cai B, Barbone A, Madigan J, Reiken S, Lee D, Oz M, Marks A, Burkhoff D. Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure. Circulation 2000, 102: 2713-2719. PMID: 11094037, DOI: 10.1161/01.cir.102.22.2713.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlotting, NorthernBlotting, WesternCalcium-Transporting ATPasesFemaleGene Expression RegulationHeart FailureHeart VentriclesHeart-Assist DevicesHumansMaleMiddle AgedMyocardial ContractionRNA, MessengerRyanodine Receptor Calcium Release ChannelSarcolemmaSodium-Hydrogen ExchangersConceptsEnd-stage heart failureLVAD supportHeart failureContractile strengthLVAD implantationSarcoplasmic reticular membranesNegative FFRIntact myocardiumVentricular assist deviceBlot analysisExpression of genesWestern blot analysisContractile dysfunctionSERCA2a proteinLV trabeculaeSubtype 2aChronic unloadingLV tissueAssist deviceContractile forcePatientsAlters gene expressionHigher mRNAReticular membranesRyanodine receptor