2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRatsCharacterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload
Kheyfets V, Kumar S, Heerdt P, Ichimura K, Brown R, Lucero M, Essafri I, Williams S, Stenmark K, Spiekerkoetter E. Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload. International Journal Of Molecular Sciences 2023, 24: 9746. PMID: 37298696, PMCID: PMC10253685, DOI: 10.3390/ijms24119746.Peer-Reviewed Original ResearchConceptsPressure overloadChronic RV pressure overloadExperimental pulmonary hypertension modelsRV pressure overloadTime pointsPulmonary hypertension modelRV outflow tractTranscriptomic signaturesAcute pressure overloadRight ventricular tissueDifferent time pointsPulmonary embolismHypertension modelSevere PEAcute increaseInitial insultOutflow tractRight ventricleRV apexVentricular tissueControl tissuesRatsSeverityWeeksTissue
2006
Cardiomyopathic Etiology and SERCA2a Reverse Remodeling During Mechanical Support of the Failing Human Heart
Heerdt PM, Klotz S, Burkhoff D. Cardiomyopathic Etiology and SERCA2a Reverse Remodeling During Mechanical Support of the Failing Human Heart. Anesthesia & Analgesia 2006, 102: 32-37. PMID: 16368801, DOI: 10.1213/01.ane.0000183642.09435.ad.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnimalsBiomechanical PhenomenaCalcium-Transporting ATPasesCardiomyopathy, DilatedConfidence IntervalsDatabases, FactualFemaleGene Expression Regulation, EnzymologicHeart-Assist DevicesHumansIn Vitro TechniquesMaleMiddle AgedRatsSarcoplasmic Reticulum Calcium-Transporting ATPasesVentricular RemodelingConceptsLeft ventricular assist deviceForce-frequency relationshipSERCA2a functionMyocardial force-frequency relationshipMyocyte calcium cyclingSERCA2a gene expressionFailing Human HeartVentricular assist deviceChronic failureProportion of trabeculaeReverse remodelingLVAD supportMyopathic originSubtype 2aDCM heartsDisease processSERCA2a mRNAAssist deviceCalcium cyclingHeart samplesAbnormal expressionMyocardial trabeculaeGene expressionMolecular remodelingHuman heart