2017
Single-lung ventilation and oxidative stress
Heerdt PM, Stowe DF. Single-lung ventilation and oxidative stress. Current Opinion In Anaesthesiology 2017, 30: 42-49. PMID: 27783023, DOI: 10.1097/aco.0000000000000410.Peer-Reviewed Original ResearchConceptsSingle-lung ventilationOxidative stressRe-expanded lungHypoxic pulmonary vasoconstrictionRedistribution of bloodLocal tissue hypoxiaPostoperative disruptionPulmonary vasoconstrictionReperfusion responseAtelectatic lungTissue hypoxiaClinical dataReactive oxygenSystemic effectsOrgan functionLungNitrosative stressVentilationNitrogen speciesVasoconstriction
2011
Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles
Heerdt PM, Wagner CL, DeMais M, Savarese JJ. Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles. Journal Of Pharmacological And Toxicological Methods 2011, 64: 111-118. PMID: 21440649, DOI: 10.1016/j.vascn.2011.03.006.Peer-Reviewed Original ResearchConceptsCardiac outputAortic blood flowDrug-induced changesBlood flowAcute drug-induced changesNoninvasive cardiac output monitoringNon-invasive measurementOpen-chest beaglesNeuromuscular blocking drugsPreclinical drug evaluationCardiac output monitoringDrug evaluation studiesML/minSimultaneous CO measurementsBlocking drugsAcute alterationsAortic rootPreclinical screeningChest instrumentationNICOMCO measurementsOutput monitoringDrug evaluationInvasive measurementsInvasive instrumentation
2006
Hemodynamic Effects of Di-Sec-Butyl Phenol, an Anesthetic Substituted Phenol
Deau J, Heerdt PM, H.S. The A, Wang Q. Hemodynamic Effects of Di-Sec-Butyl Phenol, an Anesthetic Substituted Phenol. Pharmacology 2006, 76: 117-122. PMID: 16374073, DOI: 10.1159/000090501.Peer-Reviewed Original ResearchConceptsMean blood pressureBlood pressureHeart rateHemodynamic effectsSympathetic nervous systemAge-dependent elevationHuman neuroblastoma cell lineRelease of catecholaminesSH-SY5Y cellsNeuroblastoma cell linesGanglionic blockadeNorepinephrine releaseNervous systemControl valuesYoung rabbitsCell linesElderly rabbitsRabbitsHypnosisHexamethoniumBlockadeCatecholaminesDoseRelease
2005
Anesthetic-Induced Alteration in Expression of Myocardial Calcium Cycling Proteins
Heerdt PM, H.S. The A, Markov NP. Anesthetic-Induced Alteration in Expression of Myocardial Calcium Cycling Proteins. Journal Of Cardiothoracic And Vascular Anesthesia 2005, 19: 340-344. PMID: 16130061, DOI: 10.1053/j.jvca.2005.02.007.Peer-Reviewed Original ResearchConceptsCalcium cycling proteinsCycling proteinsSarcolemmal sodium-calcium exchangerMolecular remodelingInduction of anesthesiaNew Zealand white rabbitsEnd-tidal halothaneGroups of rabbitsZealand white rabbitsSodium-calcium exchangerHalothane doseWestern blot analysisPerioperative interventionsTracheal intubationUniversity research laboratorySubtype 2aPrior treatmentWhite rabbits
2004
Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs
Heerdt PM, Kang R, The’ A, Hashim M, Mook RJ, Savarese JJ. Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs. Anesthesiology 2004, 100: 846-851. PMID: 15087619, DOI: 10.1097/00000542-200404000-00014.Peer-Reviewed Original ResearchConceptsX ED95Cardiopulmonary changesBolus dosingDirect myocardial depressionStable neuromuscular blockadeMean arterial pressurePlasma histamine concentrationCardiopulmonary side effectsNondepolarizing neuromuscularPulmonary vasoconstrictionArterial pressureCardiovascular effectsMyocardial depressionCardiopulmonary effectsHemodynamic measurementsInspiratory pressureNeuromuscular blockadePulmonary complianceAnesthetized dogsCardiopulmonary dataMale beaglesArterial bloodED95Heart rateSide effects
2001
Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure
Barbone A, Holmes J, Heerdt P, The’ A, Naka Y, Joshi N, Daines M, Marks A, Oz M, Burkhoff D. Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure. Circulation 2001, 104: 670-675. PMID: 11489773, DOI: 10.1161/hc3101.093903.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBlood PressureCalcium-Transporting ATPasesCardiac OutputFemaleFibrosisHeart FailureHeart TransplantationHeart VentriclesHeart-Assist DevicesHemodynamicsHumansIn Vitro TechniquesLungMaleMiddle AgedSarcoplasmic Reticulum Calcium-Transporting ATPasesTime FactorsVenous PressureConceptsSevere heart failureLVAD supportRight ventricleLeft ventricleReverse remodelingHeart failureHigh central venous pressurePulmonary artery diastolic pressureVentricular assist device supportLV myocyte diameterCentral venous pressureAssist device supportHigh cardiac outputHearts of patientsForce-frequency relationVentricular assist deviceComparison of rightPossible primary roleRV trabeculaeVenous pressureVentricular responseDiastolic pressureHemodynamic unloadingCardiac outputNeurohormonal factors
1992
Intrapulmonary doppler for continuous measurement of cardiac output
Heerdt P. Intrapulmonary doppler for continuous measurement of cardiac output. Journal Of Cardiothoracic And Vascular Anesthesia 1992, 6: 382-383. PMID: 1611006, DOI: 10.1016/1053-0770(92)90178-a.Peer-Reviewed Original Research