2005
Anesthetic-Induced Alteration in Expression of Myocardial Calcium Cycling Proteins
Heerdt PM, H.S. The A, Markov NP. Anesthetic-Induced Alteration in Expression of Myocardial Calcium Cycling Proteins. Journal Of Cardiothoracic And Vascular Anesthesia 2005, 19: 340-344. PMID: 16130061, DOI: 10.1053/j.jvca.2005.02.007.Peer-Reviewed Original ResearchConceptsCalcium cycling proteinsCycling proteinsSarcolemmal sodium-calcium exchangerMolecular remodelingInduction of anesthesiaNew Zealand white rabbitsEnd-tidal halothaneGroups of rabbitsZealand white rabbitsSodium-calcium exchangerHalothane doseWestern blot analysisPerioperative interventionsTracheal intubationUniversity research laboratorySubtype 2aPrior treatmentWhite rabbits
2000
Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure
Heerdt P, Holmes J, Cai B, Barbone A, Madigan J, Reiken S, Lee D, Oz M, Marks A, Burkhoff D. Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure. Circulation 2000, 102: 2713-2719. PMID: 11094037, DOI: 10.1161/01.cir.102.22.2713.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlotting, NorthernBlotting, WesternCalcium-Transporting ATPasesFemaleGene Expression RegulationHeart FailureHeart VentriclesHeart-Assist DevicesHumansMaleMiddle AgedMyocardial ContractionRNA, MessengerRyanodine Receptor Calcium Release ChannelSarcolemmaSodium-Hydrogen ExchangersConceptsEnd-stage heart failureLVAD supportHeart failureContractile strengthLVAD implantationSarcoplasmic reticular membranesNegative FFRIntact myocardiumVentricular assist deviceBlot analysisExpression of genesWestern blot analysisContractile dysfunctionSERCA2a proteinLV trabeculaeSubtype 2aChronic unloadingLV tissueAssist deviceContractile forcePatientsAlters gene expressionHigher mRNAReticular membranesRyanodine receptor