2023
Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload
Kheyfets V, Kumar S, Heerdt P, Ichimura K, Brown R, Lucero M, Essafri I, Williams S, Stenmark K, Spiekerkoetter E. Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload. International Journal Of Molecular Sciences 2023, 24: 9746. PMID: 37298696, PMCID: PMC10253685, DOI: 10.3390/ijms24119746.Peer-Reviewed Original ResearchConceptsPressure overloadChronic RV pressure overloadExperimental pulmonary hypertension modelsRV pressure overloadTime pointsPulmonary hypertension modelRV outflow tractTranscriptomic signaturesAcute pressure overloadRight ventricular tissueDifferent time pointsPulmonary embolismHypertension modelSevere PEAcute increaseInitial insultOutflow tractRight ventricleRV apexVentricular tissueControl tissuesRatsSeverityWeeksTissue
2001
Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure
Barbone A, Holmes J, Heerdt P, The’ A, Naka Y, Joshi N, Daines M, Marks A, Oz M, Burkhoff D. Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure. Circulation 2001, 104: 670-675. PMID: 11489773, DOI: 10.1161/hc3101.093903.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBlood PressureCalcium-Transporting ATPasesCardiac OutputFemaleFibrosisHeart FailureHeart TransplantationHeart VentriclesHeart-Assist DevicesHemodynamicsHumansIn Vitro TechniquesLungMaleMiddle AgedSarcoplasmic Reticulum Calcium-Transporting ATPasesTime FactorsVenous PressureConceptsSevere heart failureLVAD supportRight ventricleLeft ventricleReverse remodelingHeart failureHigh central venous pressurePulmonary artery diastolic pressureVentricular assist device supportLV myocyte diameterCentral venous pressureAssist device supportHigh cardiac outputHearts of patientsForce-frequency relationVentricular assist deviceComparison of rightPossible primary roleRV trabeculaeVenous pressureVentricular responseDiastolic pressureHemodynamic unloadingCardiac outputNeurohormonal factors
1998
Disparity of Isoflurane Effects on Left and Right Ventricular Afterload and Hydraulic Power Generation in Swine
Heerdt P, Gandhi C, Dickstein M. Disparity of Isoflurane Effects on Left and Right Ventricular Afterload and Hydraulic Power Generation in Swine. Anesthesia & Analgesia 1998, 87: 511-521.. DOI: 10.1213/00000539-199809000-00002.Peer-Reviewed Original ResearchConceptsPreload recruitable stroke work slopeDose-related decreaseRight ventricleLeft ventricleISO groupMinimum alveolar anesthetic concentration (MAC) isofluraneIso animalsPulmonary arterial blood flowIsoflurane-induced alterationsTotal arterial resistanceDose-related effectsEffects of isofluranePeak systolic pressureAutonomic nervous activityArterial blood flowGroups of swineRegional segment lengthVolatile Anesthetic EffectsEjection of bloodBiventricular contractilityRV contractilityVascular effectsVentricular afterloadSystolic pressureLV afterloadDisparity of isoflurane effects on left and right ventricular afterload and hydraulic power generation in swine.
Heerdt P, Gandhi C, Dickstein M. Disparity of isoflurane effects on left and right ventricular afterload and hydraulic power generation in swine. Anesthesia & Analgesia 1998, 87: 511-21. PMID: 9728819, DOI: 10.1097/00000539-199809000-00002.Peer-Reviewed Original ResearchConceptsPreload recruitable stroke work slopeDose-related decreaseRight ventricleLeft ventricleISO groupMinimum alveolar anesthetic concentration (MAC) isofluraneIso animalsPulmonary arterial blood flowIsoflurane-induced alterationsRight ventricular afterloadTotal arterial resistanceDose-related effectsEffects of isofluranePeak systolic pressureAutonomic nervous activityArterial blood flowGroups of swineRegional segment lengthVolatile Anesthetic EffectsEjection of bloodBiventricular contractilityRV contractilityVascular effectsVentricular afterloadSystolic pressure
1997
Assessment of Right Ventricular Function
Heerdt P, Dickstein M. Assessment of Right Ventricular Function. Seminars In Cardiothoracic And Vascular Anesthesia 1997, 1: 215-224. DOI: 10.1177/108925329700100304.Peer-Reviewed Original ResearchRight ventricleLeft ventricleRV functionVentricular functionRight ventricular functionPerioperative careSurgical patientsLV functionPerioperative assessmentRV performanceVenous circulationBlood flowRecent dataVentricleCharacteristics of fillingOverall functionAssessmentPatientsMajor roleLungCliniciansTractCare
1996
The Dose-Dependent Effects of Halothane on Right Ventricular Contraction Pattern and Regional Inotropy in Swine
Heerdt P, Pleimann B. The Dose-Dependent Effects of Halothane on Right Ventricular Contraction Pattern and Regional Inotropy in Swine. Anesthesia & Analgesia 1996, 82: 1152. DOI: 10.1213/00000539-199606000-00009.Peer-Reviewed Original ResearchRV contraction patternCardiac sympathovagal balanceRight ventricleContraction patternSympathovagal balanceRegional contractilityMinimum alveolar anesthetic concentration (MAC) halothaneSimilar dose-related changePreload recruitable stroke work slopeNegative inotropic effectSympathetic nervous stimulationVentricular contraction patternDose-related changesRight ventricular contraction patternEffects of halothaneDose-response effectDose-dependent effectNormal sequential patternRV contractionRV responseMAC halothaneInotropic effectAutonomic blockadeHalothane administrationTract pressure