2024
The metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner B, Joseph P, Quast A, Ramirez M, Heerdt P, Villalobos J, Singh I. The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary Circulation 2024, 14: e70009. PMID: 39544193, PMCID: PMC11560803, DOI: 10.1002/pul2.70009.Peer-Reviewed Original ResearchPeak VO<sub>2</sub>Long COVID patientsCOVID patientsReduced peak VOSeverity of SARS-CoV-2 infectionSystemic oxygen extractionSARS-CoV-2 infectionLong COVIDArterial blood samplesQuantitative metabolomicsPeak VOVenous lactateCardiac outputImpaired mitochondrial ATP productionMild infectionExercise capacityPatientsMitochondrial ATP productionExercise intoleranceArteriovenous gradientBlood samplesOxygen extractionDependent mannerMetabolomicsPhysiological impairmentEssential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period
McEvoy M, Heerdt P, Morton V, Bartz R, Miller T. Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period. Perioperative Medicine 2024, 13: 27. PMID: 38594738, PMCID: PMC11003027, DOI: 10.1186/s13741-024-00378-8.Peer-Reviewed Original ResearchRight heart physiologyPerioperative Quality InitiativePerioperative periodRight heartRight ventricular (RV) dysfunctionHeart physiologyRight-sided heart functionRight heart anatomyRight heart diseasePrevent subsequent morbidityRV dysfunctionPerioperative morbidityChronic health issuesHeart functionHeart diseasePerioperative careHeart anatomyPerioperative cliniciansMorbidityPatientsHealth issuesDysfunctionQuality Initiative
2023
Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment.
Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.Peer-Reviewed Original ResearchRight heart failureFailure patientsHeart failureTreatment optionsIntensive care unit settingMechanical circulatory support devicesIntensive care unitCirculatory support devicesCardio-pulmonary physiologyCare unitDifferent pharmacotherapiesUnit settingClinical guidancePathophysiological manifestationsCirculatory physiologyIntensivistsPatientsSupport devicesSupport optionsCirculatory systemHigh rateTreatmentDiagnosisFailureOptionsContinuous non-invasive hemodynamic monitoring in early onset severe preeclampsia
Ackerman-Banks C, Bhinder J, Eder M, Heerdt P, Sugeng L, Testani J, Alian A, Lipkind H, Velazquez E, Reddy U, Chou J. Continuous non-invasive hemodynamic monitoring in early onset severe preeclampsia. Pregnancy Hypertension 2023, 34: 27-32. PMID: 37783090, DOI: 10.1016/j.preghy.2023.09.003.Peer-Reviewed Original ResearchConceptsTotal peripheral resistanceCardiac outputSevere preeclampsiaHemodynamic monitoringEarly-onset severe preeclampsiaProspective observational studyOnset severe preeclampsiaContinuous hemodynamic monitoringNon-invasive hemodynamic monitoringEarly preeclampsiaPregnant patientsPeripheral resistanceObservational studyPreeclampsiaLow mean biasDays postpartumNICOMModerate correlationPoor correlationMean biasAntepartumPatientsProteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome
Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testPASC patientsPost-acute sequelaeAcute sequelaeInfection syndromeUnexplained exertional intoleranceCardiopulmonary exercise testSystemic oxygen deliveryPersistent inflammatory stateVenous blood plasmaExertional intolerancePeak exerciseEndothelial dysfunctionHemodynamic profileInflammatory stateExercise testFibrotic processPathophysiological hallmarkAberrant protein expressionExpression of proteinsOxygen deliveryOxygen extractionProteomic profilingPatientsPhysiologic responsesNoninvasive determinants of pulmonary hypertension in interstitial lung disease
Joseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.Peer-Reviewed Original ResearchInterstitial lung diseaseFVC/DLCO ratioPH-ILDRight heart catheterizationPulmonary hypertensionHeart catheterizationILD patientsLung diseaseDiagnostic right heart catheterizationRight ventricular systolic pressurePulmonary vascular capacitanceVentricular systolic pressureCharacteristic curve analysisMaximum oxygen uptakeExertional capacityNoninvasive determinantsSystolic pressureVascular capacitancePhysiologic evaluationPatientsNoninvasive variablesMultivariate analysisMmHgDiagnostic standardPotential initiation
2019
Flexible laryngeal mask with pharyngeal suction for nasal surgery
Zhou G, Rosenblatt W, Zhou S, Dai F, Heerdt P. Flexible laryngeal mask with pharyngeal suction for nasal surgery. Trends In Anaesthesia And Critical Care 2019, 26: 42-47. DOI: 10.1016/j.tacc.2019.04.002.Peer-Reviewed Original ResearchFlexible laryngeal maskPostoperative sore throatDuration of surgerySore throatLaryngeal maskAmount of bloodNasal surgerySuction catheterPharyngeal suctionSafe airway managementPeri-operative dataAirway-related complicationsRetrospective observational studyBlood lossAirway managementProspective studyHealthy patientsObservational studySurgeryLaryngeal surfaceCatheterBlood contaminationPatientsBloodThroat
2015
Perioperative Management of Pulmonary Hypertension
Goldsmith Y, Ivascu N, McGlothlin D, Heerdt P, Horn E. Perioperative Management of Pulmonary Hypertension. Respiratory Medicine 2015, 12: 437-464. DOI: 10.1007/978-1-4939-2636-7_19.ChaptersPulmonary hypertensionPH patientsNoncardiac surgeryPerioperative managementSpecific perioperative managementChronic pulmonary hypertensionRight ventricular failureRight ventricular physiologySeverity of diseaseImpact of chronicPulmonary vasodilatorsPerioperative riskVentricular failurePerioperative careAnesthetic planPostoperative careVentricular physiologyPH centersPreoperative preparationPatient careHypertensionPatientsSurgeryMechanical interventionMultidisciplinary approach
2012
Anesthesia and Pulmonary Hypertension
McGlothlin D, Ivascu N, Heerdt PM. Anesthesia and Pulmonary Hypertension. Progress In Cardiovascular Diseases 2012, 55: 199-217. PMID: 23009916, DOI: 10.1016/j.pcad.2012.08.002.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionNon-cardiothoracic surgeryThorough multidisciplinary planningOperative risk factorsRight ventricular failurePulmonary arterial hypertensionPreoperative risk assessmentCareful intraoperative managementArterial hypertensionPostoperative complicationsPostoperative hypoxemiaVentricular failureCardiac surgeryIntraoperative managementAnesthetic approachEarly recognitionMyocardial ischemiaRisk factorsMultidisciplinary planningHypertensionPatientsSurgerySuccessful managementAnesthesiaHypoxemia
2009
The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly
Heerdt PM, Park BJ. The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly. Thoracic Surgery Clinics 2009, 19: 345-351. PMID: 20066946, DOI: 10.1016/j.thorsurg.2009.06.006.Peer-Reviewed Original ResearchElderly patientsLung cancerSurgical techniqueRisk/benefit relationshipPreoperative functional statusHealthy elderly patientsInvasive surgical techniquesNeoadjuvant therapyPerioperative morbidityPhysiologic reserveSurgical candidatesLung malignancyPerioperative stressConventional thoracotomyGeriatric patientsOncologic efficacyFunctional statusPopulation agesPatientsEmerging RoleCancerAgeTreatmentNormal processComorbidities
2008
Practice Patterns in Choice of Left Double-Lumen Tube Size for Thoracic Surgery
Amar D, Desiderio DP, Heerdt PM, Kolker AC, Zhang H, Thaler HT. Practice Patterns in Choice of Left Double-Lumen Tube Size for Thoracic Surgery. Anesthesia & Analgesia 2008, 106: 379-383. PMID: 18227288, DOI: 10.1213/ane.0b013e3181602e41.Peer-Reviewed Original ResearchConceptsDouble-lumen tubeFr double lumen tubeLung isolationDLT repositioningThoracic surgeryDouble-lumen tube sizeSized double-lumen tubePilot studyIntraoperative outcome measuresLeft mainstem bronchusProspective pilot studyIntraoperative hypoxemiaAirway traumaTransient hypoxemiaFiberoptic bronchoscopyMainstem bronchusIntraoperative outcomesSimilar incidenceBronchial cuffDLT sizePractice patternsOutcome measuresSurgeryHypoxemiaPatients
2000
Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure
Heerdt P, Holmes J, Cai B, Barbone A, Madigan J, Reiken S, Lee D, Oz M, Marks A, Burkhoff D. Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure. Circulation 2000, 102: 2713-2719. PMID: 11094037, DOI: 10.1161/01.cir.102.22.2713.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlotting, NorthernBlotting, WesternCalcium-Transporting ATPasesFemaleGene Expression RegulationHeart FailureHeart VentriclesHeart-Assist DevicesHumansMaleMiddle AgedMyocardial ContractionRNA, MessengerRyanodine Receptor Calcium Release ChannelSarcolemmaSodium-Hydrogen ExchangersConceptsEnd-stage heart failureLVAD supportHeart failureContractile strengthLVAD implantationSarcoplasmic reticular membranesNegative FFRIntact myocardiumVentricular assist deviceBlot analysisExpression of genesWestern blot analysisContractile dysfunctionSERCA2a proteinLV trabeculaeSubtype 2aChronic unloadingLV tissueAssist deviceContractile forcePatientsAlters gene expressionHigher mRNAReticular membranesRyanodine receptor
1997
Assessment of Right Ventricular Function
Heerdt P, Dickstein M. Assessment of Right Ventricular Function. Seminars In Cardiothoracic And Vascular Anesthesia 1997, 1: 215-224. DOI: 10.1177/108925329700100304.Peer-Reviewed Original ResearchRight ventricleLeft ventricleRV functionVentricular functionRight ventricular functionPerioperative careSurgical patientsLV functionPerioperative assessmentRV performanceVenous circulationBlood flowRecent dataVentricleCharacteristics of fillingOverall functionAssessmentPatientsMajor roleLungCliniciansTractCare
1992
Comparison of cardiac output measured by intrapulmonary artery doppler, thermodilution, and electromagnetometry
Heerdt P, Pond C, Blessios G, Rosenbloom M. Comparison of cardiac output measured by intrapulmonary artery doppler, thermodilution, and electromagnetometry. The Annals Of Thoracic Surgery 1992, 54: 959-966. PMID: 1417293, DOI: 10.1016/0003-4975(92)90660-v.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassCardiac outputElective coronary artery bypassIntrapulmonary artery DopplerCardiac surgical patientsCoronary artery bypassCardiac output measurementsArtery DopplerArtery bypassSurgical patientsCatheter withdrawalCatheter systemThermodilutionBypassPatientsDoppler transducerMedian absolute errorModerate correlationPresent studyEM flowElectromagnetic flowDecannulationAortaMalpositionInaccuracy of cardiac output by thermodilution during acute tricuspid regurgitation
Heerdt P, Pond C, Blessios G, Rosenbloom M. Inaccuracy of cardiac output by thermodilution during acute tricuspid regurgitation. The Annals Of Thoracic Surgery 1992, 53: 706-708. PMID: 1554289, DOI: 10.1016/0003-4975(92)90342-2.Peer-Reviewed Original Research