ATP-Induced Modulation of Norepinephrine Exocytosis in Human and Porcine Heart: Role of E-NTPDase1/CD39.
Machida T, Heerdt P, Reid A, Schaefer U, Silver R, Broekman M, Marcus A, Levi R. ATP-Induced Modulation of Norepinephrine Exocytosis in Human and Porcine Heart: Role of E-NTPDase1/CD39. Blood 2004, 104: 1869. DOI: 10.1182/blood.v104.11.1869.1869.Peer-Reviewed Original ResearchE-NTPDase1/CD39NE exocytosisSympathetic nerve terminalsNE releaseNovel therapeutic approachesMyocardial ischemiaNerve terminalsTherapeutic approachesCardiac sympathetic nerve terminalsCoronary vascular dysfunctionSympathetic nerve endingsIschemic heart diseaseActivation of ATPGuinea pig heartsImportant modulatory roleAnti-thrombotic agentsCause of dysfunctionDepolarization of synaptosomesRelease of ATPAdrenergic neurotransmissionCardiac neuronsIschemic complicationsSympathetic terminalsP2X purinoceptorsVascular dysfunction