2019
24 Cardiovascular Physiology Integrative Function
Crystal G, Assaad S, Heerdt P, Desso R, Swenson J, Kolbay P, Kuck K, Decou J. 24 Cardiovascular Physiology Integrative Function. 2019, 473-519. DOI: 10.1016/b978-0-323-48110-6.00024-7.ChaptersBlood flowPerioperative cardiovascular monitoringEnd-systolic pressure-volume relationPulmonary artery catheterMyocardial oxygen demandCoronary blood flowSufficient blood flowCardiac function curveTissue blood flowTissue oxygen deliveryPressure-volume loopsTissue oxygen consumptionCirculatory reflexesPerioperative periodArtery catheterBody tissuesEjection fractionPressure-volume relationCardiac outputCardiac functionMyocardial contractilityMyocardial ischemiaStroke volumePatient managementOxygen delivery
2012
Anesthesia and Pulmonary Hypertension
McGlothlin D, Ivascu N, Heerdt PM. Anesthesia and Pulmonary Hypertension. Progress In Cardiovascular Diseases 2012, 55: 199-217. PMID: 23009916, DOI: 10.1016/j.pcad.2012.08.002.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionNon-cardiothoracic surgeryThorough multidisciplinary planningOperative risk factorsRight ventricular failurePulmonary arterial hypertensionPreoperative risk assessmentCareful intraoperative managementArterial hypertensionPostoperative complicationsPostoperative hypoxemiaVentricular failureCardiac surgeryIntraoperative managementAnesthetic approachEarly recognitionMyocardial ischemiaRisk factorsMultidisciplinary planningHypertensionPatientsSurgerySuccessful managementAnesthesiaHypoxemia
2004
ATP-Induced Modulation of Norepinephrine Exocytosis in Human and Porcine Heart: Role of E-NTPDase1/CD39.
Machida T, Heerdt P, Reid A, Schaefer U, Silver R, Broekman M, Marcus A, Levi R. ATP-Induced Modulation of Norepinephrine Exocytosis in Human and Porcine Heart: Role of E-NTPDase1/CD39. Blood 2004, 104: 1869. DOI: 10.1182/blood.v104.11.1869.1869.Peer-Reviewed Original ResearchE-NTPDase1/CD39NE exocytosisSympathetic nerve terminalsNE releaseNovel therapeutic approachesMyocardial ischemiaNerve terminalsTherapeutic approachesCardiac sympathetic nerve terminalsCoronary vascular dysfunctionSympathetic nerve endingsIschemic heart diseaseActivation of ATPGuinea pig heartsImportant modulatory roleAnti-thrombotic agentsCause of dysfunctionDepolarization of synaptosomesRelease of ATPAdrenergic neurotransmissionCardiac neuronsIschemic complicationsSympathetic terminalsP2X purinoceptorsVascular dysfunction