2024
The metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner B, Joseph P, Quast A, Ramirez M, Heerdt P, Villalobos J, Singh I. The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary Circulation 2024, 14: e70009. PMID: 39544193, PMCID: PMC11560803, DOI: 10.1002/pul2.70009.Peer-Reviewed Original ResearchPeak VO<sub>2</sub>Long COVID patientsCOVID patientsReduced peak VOSeverity of SARS-CoV-2 infectionSystemic oxygen extractionSARS-CoV-2 infectionLong COVIDArterial blood samplesQuantitative metabolomicsPeak VOVenous lactateCardiac outputImpaired mitochondrial ATP productionMild infectionExercise capacityPatientsMitochondrial ATP productionExercise intoleranceArteriovenous gradientBlood samplesOxygen extractionDependent mannerMetabolomicsPhysiological impairment
2023
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalitiesContinuous non-invasive hemodynamic monitoring in early onset severe preeclampsia
Ackerman-Banks C, Bhinder J, Eder M, Heerdt P, Sugeng L, Testani J, Alian A, Lipkind H, Velazquez E, Reddy U, Chou J. Continuous non-invasive hemodynamic monitoring in early onset severe preeclampsia. Pregnancy Hypertension 2023, 34: 27-32. PMID: 37783090, DOI: 10.1016/j.preghy.2023.09.003.Peer-Reviewed Original ResearchConceptsTotal peripheral resistanceCardiac outputSevere preeclampsiaHemodynamic monitoringEarly-onset severe preeclampsiaProspective observational studyOnset severe preeclampsiaContinuous hemodynamic monitoringNon-invasive hemodynamic monitoringEarly preeclampsiaPregnant patientsPeripheral resistanceObservational studyPreeclampsiaLow mean biasDays postpartumNICOMModerate correlationPoor correlationMean biasAntepartumPatients
2019
Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output
Berlin DA, Manoach S, Oromendia C, Heerdt PM. Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output. Intensive Care Medicine Experimental 2019, 7: 6. PMID: 30627962, PMCID: PMC6326914, DOI: 10.1186/s40635-018-0217-y.Peer-Reviewed Original ResearchConventional positive pressure ventilationExpiratory ventilation assistancePositive pressure ventilationSmall endotracheal tubeMedian cardiac outputVenous returnCardiac outputPressure ventilationEndotracheal tubeArterial pressureConventional ventilationVentilation assistanceLow central venous pressureCentral venous pressureSystemic arterial pressureEVA groupPEEP 0Venous pressureExpiratory pressureStroke volumeControl groupPorcine modelEffective ventilationVentilationHemorrhage24 Cardiovascular Physiology Integrative Function
Crystal G, Assaad S, Heerdt P, Desso R, Swenson J, Kolbay P, Kuck K, Decou J. 24 Cardiovascular Physiology Integrative Function. 2019, 473-519. DOI: 10.1016/b978-0-323-48110-6.00024-7.ChaptersBlood flowPerioperative cardiovascular monitoringEnd-systolic pressure-volume relationPulmonary artery catheterMyocardial oxygen demandCoronary blood flowSufficient blood flowCardiac function curveTissue blood flowTissue oxygen deliveryPressure-volume loopsTissue oxygen consumptionCirculatory reflexesPerioperative periodArtery catheterBody tissuesEjection fractionPressure-volume relationCardiac outputCardiac functionMyocardial contractilityMyocardial ischemiaStroke volumePatient managementOxygen delivery
2017
Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution During Hemorrhagic Shock and Resuscitation in Adult Swine
Berlin DA, Peprah-Mensah H, Manoach S, Heerdt PM. Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution During Hemorrhagic Shock and Resuscitation in Adult Swine. Critical Care Medicine 2017, 45: e195-e201. PMID: 27749345, DOI: 10.1097/ccm.0000000000002071.Peer-Reviewed Original ResearchConceptsNoninvasive cardiac output monitoringCardiac output monitoringThermodilution cardiac outputCardiac outputOutput monitoringArtery catheterHemorrhagic shockBolus thermodilutionIntermittent bolus thermodilutionFemoral artery catheterPulmonary artery catheterAdult porcine modelBlood pressure measurementsLaboratory animal investigationFour-quadrant plotLimits of agreementShed bloodBland-Altman analysisAnimal investigationsPlasma lactateThermodilution measurementsResuscitationYorkshire swineAdult swinePorcine model
2015
Non-invasive cardiac output monitoring for cesarean delivery under epidural anesthesia in a patient with Marfan syndrome and cardiomyopathy
Beaudry S, Pick J, Heerdt P. Non-invasive cardiac output monitoring for cesarean delivery under epidural anesthesia in a patient with Marfan syndrome and cardiomyopathy. International Journal Of Obstetric Anesthesia 2015, 25: 82-85. PMID: 26718697, DOI: 10.1016/j.ijoa.2015.11.003.Peer-Reviewed Original ResearchConceptsNon-invasive cardiac output monitoringCardiac outputCardiac output monitoringCesarean deliveryStroke volumeEpidural anesthesiaBaseline valuesMarfan syndromeLeft ventricular ejection fractionOutput monitoringUse of phenylephrineEnd of surgeryIntravascular volume depletionMaternal cardiac outputMitral valve replacementSystemic blood pressureAdequate surgical anesthesiaClose hemodynamic monitoringVentricular ejection fractionAcute blood lossAcute volume overloadStroke volume increaseValve replacementBlood lossBlood pressure
2011
Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles
Heerdt PM, Wagner CL, DeMais M, Savarese JJ. Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles. Journal Of Pharmacological And Toxicological Methods 2011, 64: 111-118. PMID: 21440649, DOI: 10.1016/j.vascn.2011.03.006.Peer-Reviewed Original ResearchConceptsCardiac outputAortic blood flowDrug-induced changesBlood flowAcute drug-induced changesNoninvasive cardiac output monitoringNon-invasive measurementOpen-chest beaglesNeuromuscular blocking drugsPreclinical drug evaluationCardiac output monitoringDrug evaluation studiesML/minSimultaneous CO measurementsBlocking drugsAcute alterationsAortic rootPreclinical screeningChest instrumentationNICOMCO measurementsOutput monitoringDrug evaluationInvasive measurementsInvasive instrumentation
2010
Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ. Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs. Anesthesiology 2010, 112: 910-916. PMID: 20234311, DOI: 10.1097/aln.0b013e3181d31f71.Peer-Reviewed Original ResearchConceptsX ED95Neuromuscular blocking drugsCardiopulmonary side effectsVascular resistanceArterial pressureBlocking drugsCardiac outputHistamine releaseSide effectsMean pulmonary artery pressurePulmonary artery pressurePulmonary vascular resistanceSystemic vascular resistanceMean arterial pressurePulmonary arterial pressureArtery pressureHemodynamic effectsPulmonary complianceVentricular contractilityInspiratory pressureNeuromuscular blockadeVentricular pressureED95Large dosesCW002
2001
Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure
Barbone A, Holmes J, Heerdt P, The’ A, Naka Y, Joshi N, Daines M, Marks A, Oz M, Burkhoff D. Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure. Circulation 2001, 104: 670-675. PMID: 11489773, DOI: 10.1161/hc3101.093903.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBlood PressureCalcium-Transporting ATPasesCardiac OutputFemaleFibrosisHeart FailureHeart TransplantationHeart VentriclesHeart-Assist DevicesHemodynamicsHumansIn Vitro TechniquesLungMaleMiddle AgedSarcoplasmic Reticulum Calcium-Transporting ATPasesTime FactorsVenous PressureConceptsSevere heart failureLVAD supportRight ventricleLeft ventricleReverse remodelingHeart failureHigh central venous pressurePulmonary artery diastolic pressureVentricular assist device supportLV myocyte diameterCentral venous pressureAssist device supportHigh cardiac outputHearts of patientsForce-frequency relationVentricular assist deviceComparison of rightPossible primary roleRV trabeculaeVenous pressureVentricular responseDiastolic pressureHemodynamic unloadingCardiac outputNeurohormonal factorsFlow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation
Heerdt P, Blessios G, Beach M, Hogue C. Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation. Journal Of Cardiothoracic And Vascular Anesthesia 2001, 15: 183-187. PMID: 11312476, DOI: 10.1053/jcan.2001.21947.Peer-Reviewed Original ResearchConceptsAcute tricuspid regurgitationTricuspid regurgitationCardiac outputArteriovenous shuntsSevere regurgitationVenous returnPeripheral arteriovenous shuntsSevere tricuspid regurgitationThermodilution cardiac output measurementsAnesthetized mongrel dogsThermodilution cardiac outputCardiac output measurementsElectromagnetic flowMongrel dogsRegurgitationAnimal studiesThermodilution measurementsShuntThermodilutionVariable degreesMinimal effectMin
1997
Effects of Vasoactive Medications on the Blood Flow of Island Musculocutaneous Flaps in Swine
Cordeiro P, Santamaria E, Hu Q, Heerdt P. Effects of Vasoactive Medications on the Blood Flow of Island Musculocutaneous Flaps in Swine. Annals Of Plastic Surgery 1997, 39: 524-531. PMID: 9374150, DOI: 10.1097/00000637-199711000-00013.Peer-Reviewed Original ResearchConceptsCardiac outputHigh dosesBlood flowMusculocutaneous flapFlap flowPoor-risk patientsRectus abdominis musculocutaneous flapArterial blood pressureDoses of phenylephrineTotal cardiac outputMicrosurgical free tissue transferAortic root pressureMusculocutaneous flap modelFree tissue transferPressure/flow relationshipVasoactive medicationsRisk patientsVasopressor drugsBlood pressureVasoactive substancesPulmonary arteryVasoactive agentsHemodynamic parametersHemodynamic studiesDobutamine
1992
Comparison of cardiac output measured by intrapulmonary artery doppler, thermodilution, and electromagnetometry
Heerdt P, Pond C, Blessios G, Rosenbloom M. Comparison of cardiac output measured by intrapulmonary artery doppler, thermodilution, and electromagnetometry. The Annals Of Thoracic Surgery 1992, 54: 959-966. PMID: 1417293, DOI: 10.1016/0003-4975(92)90660-v.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassCardiac outputElective coronary artery bypassIntrapulmonary artery DopplerCardiac surgical patientsCoronary artery bypassCardiac output measurementsArtery DopplerArtery bypassSurgical patientsCatheter withdrawalCatheter systemThermodilutionBypassPatientsDoppler transducerMedian absolute errorModerate correlationPresent studyEM flowElectromagnetic flowDecannulationAortaMalpositionInaccuracy of cardiac output by thermodilution during acute tricuspid regurgitation
Heerdt P, Pond C, Blessios G, Rosenbloom M. Inaccuracy of cardiac output by thermodilution during acute tricuspid regurgitation. The Annals Of Thoracic Surgery 1992, 53: 706-708. PMID: 1554289, DOI: 10.1016/0003-4975(92)90342-2.Peer-Reviewed Original Research
1990
Prostaglandin E1 and intrapulmonary shunt in cardiac surgical patients with pulmonary hypertension
Heerdt P, Weiss C. Prostaglandin E1 and intrapulmonary shunt in cardiac surgical patients with pulmonary hypertension. The Annals Of Thoracic Surgery 1990, 49: 463-465. PMID: 2106846, DOI: 10.1016/0003-4975(90)90257-7.Peer-Reviewed Original ResearchConceptsPulmonary vascular resistancePulmonary capillary wedge pressureCapillary wedge pressurePulmonary arterial pressureSystemic vascular resistanceVascular resistanceIntrapulmonary shuntPulmonary hypertensionProstaglandin E1Wedge pressureArterial pressureSurgical patientsCardiac outputElevated pulmonary vascular resistanceMean pulmonary arterial pressureAdult respiratory distress syndromeMixed venous oxygen tensionPulmonary vascular responseCardiac surgical patientsRight atrial pressureRespiratory distress syndromeProstaglandin E1 infusionPulmonary arterial catheterRadial arterial cannulaVenous oxygen tension