2016
Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
Heerdt PM, Sunaga H, Owen JS, Murrell MT, Malhotra JK, Godfrey D, Steinkamp M, Savard P, Savarese JJ, Lien CA. Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man. Anesthesiology 2016, 125: 1136-1143. PMID: 27749289, DOI: 10.1097/aln.0000000000001386.Peer-Reviewed Original ResearchConceptsCardiopulmonary side effectsHistamine releaseSide effectsBlood pressureHealthy subjectsHeart rateSevoflurane/nitrous oxideDose-escalation clinical trialDynamic airway complianceNeuromuscular-blocking drugsEscalation clinical trialPlasma histamine concentrationSigmoid Emax modelClinical recoveryClinical durationAdductor pollicisTwitch depressionAirway complianceNeuromuscular blockadeClinical trialsPreclinical studiesArterial bloodEmax modelHistamine concentrationCW002
2015
Non-invasive cardiac output monitoring for cesarean delivery under epidural anesthesia in a patient with Marfan syndrome and cardiomyopathy
Beaudry S, Pick J, Heerdt P. Non-invasive cardiac output monitoring for cesarean delivery under epidural anesthesia in a patient with Marfan syndrome and cardiomyopathy. International Journal Of Obstetric Anesthesia 2015, 25: 82-85. PMID: 26718697, DOI: 10.1016/j.ijoa.2015.11.003.Peer-Reviewed Original ResearchConceptsNon-invasive cardiac output monitoringCardiac outputCardiac output monitoringCesarean deliveryStroke volumeEpidural anesthesiaBaseline valuesMarfan syndromeLeft ventricular ejection fractionOutput monitoringUse of phenylephrineEnd of surgeryIntravascular volume depletionMaternal cardiac outputMitral valve replacementSystemic blood pressureAdequate surgical anesthesiaClose hemodynamic monitoringVentricular ejection fractionAcute blood lossAcute volume overloadStroke volume increaseValve replacementBlood lossBlood pressure
2010
Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs
Sunaga H, Malhotra JK, Yoon E, Savarese JJ, Heerdt PM. Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs. Anesthesiology 2010, 112: 900-909. PMID: 20234310, DOI: 10.1097/aln.0b013e3181d31f8c.Peer-Reviewed Original ResearchConceptsOrgan toxicityHeart rateIsoflurane-nitrous oxide anesthesiaAcute cardiovascular effectsNeuromuscular blocking drugsDose-response relationshipDose-dependent mannerEndogenous L-cysteineCardiovascular effectsHemodynamic effectsMedian durationArterial pressureBlood pressureBlocking drugsHistologic evidenceNeuromuscular blockadeOxide anesthesiaTwitch recoveryMuscle recoveryHistopathologic analysisMuscle twitchLarge doseCW002Additional groupDose
2006
Hemodynamic Effects of Di-Sec-Butyl Phenol, an Anesthetic Substituted Phenol
Deau J, Heerdt PM, H.S. The A, Wang Q. Hemodynamic Effects of Di-Sec-Butyl Phenol, an Anesthetic Substituted Phenol. Pharmacology 2006, 76: 117-122. PMID: 16374073, DOI: 10.1159/000090501.Peer-Reviewed Original ResearchConceptsMean blood pressureBlood pressureHeart rateHemodynamic effectsSympathetic nervous systemAge-dependent elevationHuman neuroblastoma cell lineRelease of catecholaminesSH-SY5Y cellsNeuroblastoma cell linesGanglionic blockadeNorepinephrine releaseNervous systemControl valuesYoung rabbitsCell linesElderly rabbitsRabbitsHypnosisHexamethoniumBlockadeCatecholaminesDoseRelease
2002
Age-Related Hypotension Following Induction of Anesthesia with Propofol: The Role of Dampened Reflex Regulation of Blood Pressure
Memtsoudis S, The A, Heerdt P. Age-Related Hypotension Following Induction of Anesthesia with Propofol: The Role of Dampened Reflex Regulation of Blood Pressure. Anesthesiology 2002, 96: a706. DOI: 10.1097/00000542-200209002-00706.Peer-Reviewed Original Research
1997
Effects of Vasoactive Medications on the Blood Flow of Island Musculocutaneous Flaps in Swine
Cordeiro P, Santamaria E, Hu Q, Heerdt P. Effects of Vasoactive Medications on the Blood Flow of Island Musculocutaneous Flaps in Swine. Annals Of Plastic Surgery 1997, 39: 524-531. PMID: 9374150, DOI: 10.1097/00000637-199711000-00013.Peer-Reviewed Original ResearchConceptsCardiac outputHigh dosesBlood flowMusculocutaneous flapFlap flowPoor-risk patientsRectus abdominis musculocutaneous flapArterial blood pressureDoses of phenylephrineTotal cardiac outputMicrosurgical free tissue transferAortic root pressureMusculocutaneous flap modelFree tissue transferPressure/flow relationshipVasoactive medicationsRisk patientsVasopressor drugsBlood pressureVasoactive substancesPulmonary arteryVasoactive agentsHemodynamic parametersHemodynamic studiesDobutamine