2016
Local Arp2/3-dependent actin assembly modulates applied traction force during apCAM adhesion site maturation
Buck KB, Schaefer AW, Schoonderwoert VT, Creamer MS, Dufresne ER, Forscher P. Local Arp2/3-dependent actin assembly modulates applied traction force during apCAM adhesion site maturation. Molecular Biology Of The Cell 2016, 28: 98-110. PMID: 27852899, PMCID: PMC5221634, DOI: 10.1091/mbc.e16-04-0228.Peer-Reviewed Original Research
2008
Coordination of Actin Filament and Microtubule Dynamics during Neurite Outgrowth
Schaefer AW, Schoonderwoert VT, Ji L, Mederios N, Danuser G, Forscher P. Coordination of Actin Filament and Microtubule Dynamics during Neurite Outgrowth. Developmental Cell 2008, 15: 146-162. PMID: 18606148, PMCID: PMC2595147, DOI: 10.1016/j.devcel.2008.05.003.Peer-Reviewed Original ResearchConceptsRetrograde actin network flowActin network flowNeurite outgrowthMyosin II contractilityRho-kinaseCell adhesion substratesCytoskeletal dynamicsMicrotubule behaviorAdhesion sitesAdhesion substrateMicrotubule dynamicsMyosin IIActin filamentsMolecular eventsGrowth responseMicrotubule movementKinaseNeuronal growthMicrotubulesOutgrowthGrowth cone neckGrowthOrganellesRegulationCascade
2001
Transmission of growth cone traction force through apCAM–cytoskeletal linkages is regulated by Src family tyrosine kinase activity
Suter D, Forscher P. Transmission of growth cone traction force through apCAM–cytoskeletal linkages is regulated by Src family tyrosine kinase activity. Journal Of Cell Biology 2001, 155: 427-438. PMID: 11673478, PMCID: PMC2150837, DOI: 10.1083/jcb.200107063.Peer-Reviewed Original ResearchProtein Kinase C Activation Promotes Microtubule Advance in Neuronal Growth Cones by Increasing Average Microtubule Growth Lifetimes
Kabir N, Schaefer A, Nakhost A, Sossin W, Forscher P. Protein Kinase C Activation Promotes Microtubule Advance in Neuronal Growth Cones by Increasing Average Microtubule Growth Lifetimes. Journal Of Cell Biology 2001, 152: 1033-1044. PMID: 11238458, PMCID: PMC2198821, DOI: 10.1083/jcb.152.5.1033.Peer-Reviewed Original Research
2000
Substrate–cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance
Suter D, Forscher P. Substrate–cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance. Developmental Neurobiology 2000, 44: 97-113. PMID: 10934315, DOI: 10.1002/1097-4695(200008)44:2<97::aid-neu2>3.0.co;2-u.Peer-Reviewed Original ResearchConceptsGrowth cone motilityCone motilityGuidance cuesGrowth conesDifferent guidance cuesDynamic cytoskeletonCell adhesion moleculeSignal transducerAxon guidanceMolecular componentsCytoskeletonMotile structuresMotility deviceAppropriate target cellsDifferent functionsRespective receptorsAdhesion moleculesProteinAxonal growthMotilityGrowth cone movementTarget cellsNeuronal processesRecent evidenceCone movement
1999
A diffusion barrier maintains distribution of membrane proteins in polarized neurons
Winckler B, Forscher P, Mellman I. A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature 1999, 397: 698-701. PMID: 10067893, DOI: 10.1038/17806.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAxonsBiological TransportCell CompartmentationCell MembraneCell PolarityCells, CulturedCytoskeletonDiffusionDimethyl SulfoxideLeukocyte L1 Antigen ComplexMembrane GlycoproteinsMembrane ProteinsMicrospheresNeural Cell Adhesion MoleculesNeuronsRatsReceptors, AMPAThy-1 AntigensConceptsMembrane proteinsDiffusion barrierObvious physical barriersPlasma membrane domainsLateral mobilityOptical tweezersCell-cell contactMembrane domainsPresumptive domainPolarized neuronsPlasma membraneCytoskeletal componentsPolarized distributionF-actinDiffusion of proteinsDistinct domainsBasolateral surfaceMembrane markersProteinSpecialized domainsInitial segmentTight junctionsAsymmetric distributionPhysical barrierTweezers
1998
The Ig Superfamily Cell Adhesion Molecule, apCAM, Mediates Growth Cone Steering by Substrate–Cytoskeletal Coupling
Suter D, Errante L, Belotserkovsky V, Forscher P. The Ig Superfamily Cell Adhesion Molecule, apCAM, Mediates Growth Cone Steering by Substrate–Cytoskeletal Coupling. Journal Of Cell Biology 1998, 141: 227-240. PMID: 9531561, PMCID: PMC2132711, DOI: 10.1083/jcb.141.1.227.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAplysiaCell Adhesion MoleculesCell MovementCells, CulturedCloning, MolecularCytoskeletonDNA PrimersGanglia, InvertebrateImmunoglobulin GKineticsMicroscopy, VideoMicrotubulesModels, BiologicalNeuronsPolymerase Chain ReactionRecombinant ProteinsSilicon DioxideStress, MechanicalTubulinAn emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance
Suter D, Forscher P. An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance. Current Opinion In Neurobiology 1998, 8: 106-116. PMID: 9568398, DOI: 10.1016/s0959-4388(98)80014-7.Peer-Reviewed Original ResearchConceptsGrowth cone guidanceCell adhesion moleculeCell surface receptorsAdhesion moleculesCytoskeletal dynamicsCytoskeletal networkCytoskeletal proteinsExtracellular substratesSurface receptorsConcerted actionMolecular motorsNeuronal growthImportant mechanismRecent studiesModulation of couplingProtein
1994
Cytoskeletal reorganization underlying growth cone motility
Lin C, Thompson C, Forscher P. Cytoskeletal reorganization underlying growth cone motility. Current Opinion In Neurobiology 1994, 4: 640-647. PMID: 7849519, DOI: 10.1016/0959-4388(94)90004-3.Peer-Reviewed Original ResearchConceptsIndividual cytoskeletal elementsGrowth cone motilityCytoskeletal dynamicsCytoskeletal reorganizationIntracellular cytoskeletonExtracellular substratesCytoskeletal elementsLiving cellsCone motilityNeuronal migrationNeuronal outgrowthFunctional couplingRecent studiesCytoskeletonImportant componentRegulation
1992
Novel form of growth cone motility involving site-directed actin filament assembly
Forscher P, Lin C, Thompson C. Novel form of growth cone motility involving site-directed actin filament assembly. Nature 1992, 357: 515-518. PMID: 1608453, DOI: 10.1038/357515a0.Peer-Reviewed Original ResearchConceptsActin filament assemblyFilament assemblyNeuronal growth conesCortical F-actin networkMembrane-cytoskeletal interfaceF-actin assemblyF-actin networkGrowth conesGrowth cone migrationGrowth cone motilityExtracellular signalsBacterial parasiteMembrane proteinsCell movementCytoskeletal structuresIntracellular movementDevelopmental processesBead movementCell locomotionCone migrationMorphogenic changesMotile cellsAxonal guidanceCone motilityCellular mechanisms
1989
Calcium and polyphosphoinositide control of cytoskeletal dynamics
Forscher P. Calcium and polyphosphoinositide control of cytoskeletal dynamics. Trends In Neurosciences 1989, 12: 468-474. PMID: 2479150, DOI: 10.1016/0166-2236(89)90098-2.Peer-Reviewed Original ResearchConceptsMajor actin-binding proteinActin-binding proteinsNeuronal cell typesCytoskeletal dynamicsCytoskeletal plasticityCytoskeletal proteinsRegulatory proteinsActin polymerizationNeuronal motilityActin filamentsMembrane interactionsCell typesNeuronal cytoskeletonProteinReceptor-mediated changesPolyphosphoinositide turnoverSynaptic functionDynamic alterationsMechanochemical propertiesAxonal growthPhosphoinositide turnoverCell structureRecent evidenceTurnoverIntracellular calcium