2012
Calcineurin-dependent cofilin activation and increased retrograde actin flow drive 5-HT–dependent neurite outgrowth in Aplysia bag cell neurons
Zhang XF, Hyland C, Van Goor D, Forscher P. Calcineurin-dependent cofilin activation and increased retrograde actin flow drive 5-HT–dependent neurite outgrowth in Aplysia bag cell neurons. Molecular Biology Of The Cell 2012, 23: 4833-4848. PMID: 23097492, PMCID: PMC3521690, DOI: 10.1091/mbc.e12-10-0715.Peer-Reviewed Original ResearchConceptsPhospholipase CNeurite outgrowthDynamic cytoskeletal processesRetrograde actin network flowP domainRetrograde actin flowActin network flowSoluble growth factorsAplysia bag cell neuronsBag cell neuronsCofilin activityWidespread mechanismCytoskeletal processesActin flowCofilin activationCell neuronsNeurite outgrowth rateMechanistic roleInositol trisphosphateOutgrowthGrowth factorDirect activationOutgrowth rateBasal levelsActivation
1989
Calcium and polyphosphoinositide control of cytoskeletal dynamics
Forscher P. Calcium and polyphosphoinositide control of cytoskeletal dynamics. Trends In Neurosciences 1989, 12: 468-474. PMID: 2479150, DOI: 10.1016/0166-2236(89)90098-2.Peer-Reviewed Original ResearchConceptsMajor actin-binding proteinActin-binding proteinsNeuronal cell typesCytoskeletal dynamicsCytoskeletal plasticityCytoskeletal proteinsRegulatory proteinsActin polymerizationNeuronal motilityActin filamentsMembrane interactionsCell typesNeuronal cytoskeletonProteinReceptor-mediated changesPolyphosphoinositide turnoverSynaptic functionDynamic alterationsMechanochemical propertiesAxonal growthPhosphoinositide turnoverCell structureRecent evidenceTurnoverIntracellular calcium