2013
Protein kinase C activation decreases peripheral actin network density and increases central nonmuscle myosin II contractility in neuronal growth cones
Yang Q, Zhang XF, Van Goor D, Dunn AP, Hyland C, Medeiros N, Forscher P. Protein kinase C activation decreases peripheral actin network density and increases central nonmuscle myosin II contractility in neuronal growth cones. Molecular Biology Of The Cell 2013, 24: 3097-3114. PMID: 23966465, PMCID: PMC3784383, DOI: 10.1091/mbc.e13-05-0289.Peer-Reviewed Original ResearchConceptsProtein kinase CMyosin II contractilityActin network densityNeuronal growth conesPKC activationCentral cytoplasmic domainRetrograde actin network flowTwo-tiered mechanismEffect of PKCActin network flowActin network structureActin filament networkGrowth conesProtein kinase C activationKinase C activationCytoplasmic domainActin polymerizationKinase CFilament networkCytoskeletal mechanismsRegulatory light chain phosphorylationPKC actionPKC activityC activationGuidance responses
1998
Binding of Protein Kinase C Isoforms to Actin in Aplysia
Nakhost A, Forscher P, Sossin W. Binding of Protein Kinase C Isoforms to Actin in Aplysia. Journal Of Neurochemistry 1998, 71: 1221-1231. PMID: 9721748, DOI: 10.1046/j.1471-4159.1998.71031221.x.Peer-Reviewed Original ResearchConceptsPKC Apl IIProtein kinase C isoformsActin filamentsTriton-insoluble fractionApl IIF-actinCytoskeletal dynamicsC isoformsPhorbol ester-dependent mannerPKC Apl IMarine mollusk Aplysia californicaPhorbol ester treatmentNeuronal growth conesMollusk Aplysia californicaPKC phosphorylationApl IPKC-epsilonPhysiological roleIndependent PKCStriking colocalizationPKC inhibitorKinasePKC betaIIEster treatmentPKC
1992
Novel form of growth cone motility involving site-directed actin filament assembly
Forscher P, Lin C, Thompson C. Novel form of growth cone motility involving site-directed actin filament assembly. Nature 1992, 357: 515-518. PMID: 1608453, DOI: 10.1038/357515a0.Peer-Reviewed Original ResearchConceptsActin filament assemblyFilament assemblyNeuronal growth conesCortical F-actin networkMembrane-cytoskeletal interfaceF-actin assemblyF-actin networkGrowth conesGrowth cone migrationGrowth cone motilityExtracellular signalsBacterial parasiteMembrane proteinsCell movementCytoskeletal structuresIntracellular movementDevelopmental processesBead movementCell locomotionCone migrationMorphogenic changesMotile cellsAxonal guidanceCone motilityCellular mechanisms