2013
Protein kinase C activation decreases peripheral actin network density and increases central nonmuscle myosin II contractility in neuronal growth cones
Yang Q, Zhang XF, Van Goor D, Dunn AP, Hyland C, Medeiros N, Forscher P. Protein kinase C activation decreases peripheral actin network density and increases central nonmuscle myosin II contractility in neuronal growth cones. Molecular Biology Of The Cell 2013, 24: 3097-3114. PMID: 23966465, PMCID: PMC3784383, DOI: 10.1091/mbc.e13-05-0289.Peer-Reviewed Original ResearchConceptsProtein kinase CMyosin II contractilityActin network densityNeuronal growth conesPKC activationCentral cytoplasmic domainRetrograde actin network flowTwo-tiered mechanismEffect of PKCActin network flowActin network structureActin filament networkGrowth conesProtein kinase C activationKinase C activationCytoplasmic domainActin polymerizationKinase CFilament networkCytoskeletal mechanismsRegulatory light chain phosphorylationPKC actionPKC activityC activationGuidance responses
1989
Calcium and polyphosphoinositide control of cytoskeletal dynamics
Forscher P. Calcium and polyphosphoinositide control of cytoskeletal dynamics. Trends In Neurosciences 1989, 12: 468-474. PMID: 2479150, DOI: 10.1016/0166-2236(89)90098-2.Peer-Reviewed Original ResearchConceptsMajor actin-binding proteinActin-binding proteinsNeuronal cell typesCytoskeletal dynamicsCytoskeletal plasticityCytoskeletal proteinsRegulatory proteinsActin polymerizationNeuronal motilityActin filamentsMembrane interactionsCell typesNeuronal cytoskeletonProteinReceptor-mediated changesPolyphosphoinositide turnoverSynaptic functionDynamic alterationsMechanochemical propertiesAxonal growthPhosphoinositide turnoverCell structureRecent evidenceTurnoverIntracellular calcium