2013
A Randomized Trial of Cognitive Behavioral Therapy in Primary Care-based Buprenorphine
Fiellin DA, Barry DT, Sullivan LE, Cutter CJ, Moore BA, O'Connor PG, Schottenfeld RS. A Randomized Trial of Cognitive Behavioral Therapy in Primary Care-based Buprenorphine. The American Journal Of Medicine 2013, 126: 74.e11-74.e17. PMID: 23260506, PMCID: PMC3621718, DOI: 10.1016/j.amjmed.2012.07.005.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPhysician managementBehavioral therapyOpioid useOpioid dependencePrimary careSelf-reported frequencyBuprenorphine/naloxone treatmentConsecutive weeksOpioid-dependent patientsIllicit opioid usePrimary care clinicsPrimary outcome measureWeeks of treatmentNaloxone treatmentOpioid abstinenceBuprenorphine/Care clinicsIllicit opioidsRandomized trialsUrine toxicologyClinical trialsStudy completionOutcome measuresCocaine use
2003
Initial and Maintenance Naltrexone Treatment for Alcohol Dependence Using Primary Care vs Specialty Care: A Nested Sequence of 3 Randomized Trials
O'Malley SS, Rounsaville BJ, Farren C, Namkoong K, Wu R, Robinson J, O'Connor PG. Initial and Maintenance Naltrexone Treatment for Alcohol Dependence Using Primary Care vs Specialty Care: A Nested Sequence of 3 Randomized Trials. JAMA Internal Medicine 2003, 163: 1695-1704. PMID: 12885685, DOI: 10.1001/archinte.163.14.1695.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlanine TransaminaseAlcoholismAspartate AminotransferasesCognitive Behavioral TherapyCombined Modality TherapyConnecticutFemaleGamma-GlutamyltransferaseHumansMaleMedicineMiddle AgedNaltrexoneNarcotic AntagonistsPatient CompliancePatient ParticipationPrimary Health CareSpecializationTimeTreatment OutcomeConceptsPrimary care managementCognitive behavior therapyPlacebo-controlled studyAlcohol dependenceNaltrexone treatmentPersistent heavy drinkingPrimary care treatmentWeeks of treatmentMaintenance of responseMaintenance of improvementCBT armCBT patientsPlacebo groupNaltrexone maintenanceRandomized trialsCare treatmentPrimary careSpecialty carePCM patientsDays abstinentNaltrexoneInitial courseCare managementCBT respondersPatients
2002
Increasing drug users’ adherence to HIV treatment: results of a peer-driven intervention feasibility study
Broadhead RS, Heckathorn DD, Altice FL, van Hulst Y, Carbone M, Friedland GH, O’Connor P, Selwyn PA. Increasing drug users’ adherence to HIV treatment: results of a peer-driven intervention feasibility study. Social Science & Medicine 2002, 55: 235-246. PMID: 12144138, DOI: 10.1016/s0277-9536(01)00167-8.Peer-Reviewed Original ResearchConceptsActive drug usersDrug users' adherenceDrug usersDrug treatmentMedical carePrimary careIntervention feasibility studySocial support structuresHealth advocatesUser adherenceTreatment program staffPeer-driven interventionHIV diseaseHIV infectionPatient adherenceSix-month studyHIV treatmentPhysician referralClinical appointmentsHIV therapeuticsCarePositive behavioral changesAdherencePeer pressureTreatment
1999
Measurement of compliance with naltrexone in the treatment of alcohol dependence: research and clinical implications.
Namkoong K, Farren CK, O'Connor PG, O'Malley SS. Measurement of compliance with naltrexone in the treatment of alcohol dependence: research and clinical implications. The Journal Of Clinical Psychiatry 1999, 60: 449-53. PMID: 10453799, DOI: 10.4088/jcp.v60n0706.Peer-Reviewed Original ResearchConceptsMedication Event Monitoring SystemMedication compliancePill countAlcohol dependenceOpen-label studyPill-taking behaviorSample of patientsEvent Monitoring SystemMeasurement of complianceEstimates of complianceCompliant groupPharmacotherapy researchTreatment outcomesClinical utilityCompliance rateNaltrexoneClinical implicationsOverall outcomeDrinking outcomesPatientsMEMS dataOutcomesCountTreatmentComplianceTuberculosis chemoprophylaxis using a liquid isoniazid‐methadone admixture for drug users in methadone maintenance
O'Connor PG, Shi JM, Henry S, Durante AJ, Friedman L, Selwyn PA. Tuberculosis chemoprophylaxis using a liquid isoniazid‐methadone admixture for drug users in methadone maintenance. Addiction 1999, 94: 1071-1075. PMID: 10707445, DOI: 10.1046/j.1360-0443.1999.947107112.x.Peer-Reviewed Original ResearchConceptsMethadone maintenanceTuberculosis chemoprophylaxisDrug usersMedian durationDaily doseOpioid-dependent drug usersProspective cohort studyMethadone maintenance programDrug treatment programsCompleting therapyINH chemoprophylaxisINH prophylaxisCohort studyEligible subjectsINH therapyCommon reasonChemoprophylaxisTherapyVitamin B6Treatment programMethadoneIsoniazidSubjectsINHDuration
1997
A Preliminary Investigation of the Management of Alcohol Dependence With Naltrexone by Primary Care Providers
O’Connor P, Farren C, Rounsaville B, O’Malley S. A Preliminary Investigation of the Management of Alcohol Dependence With Naltrexone by Primary Care Providers. The American Journal Of Medicine 1997, 103: 477-482. PMID: 9428830, DOI: 10.1016/s0002-9343(97)00271-4.Peer-Reviewed Original ResearchConceptsPrimary care providersCare providersGamma-glutamyl transferaseAlcohol dependenceDays abstinentHeavy drinkingSerum gamma-glutamyl transferaseCare treatment modelCompletion of treatmentPercent days abstinentAlcohol-dependent subjectsAlcohol-dependent individualsNaltrexone therapyNumber of drinksPrimary outcomeLiver enzymesPatient ratingsNew patientsGlutamyl transferaseNaltrexoneProvider ratingsBaselineTreatment modelTreatmentDrinking behavior
1992
Human immunodeficiency virus infection in intravenous drug users: A model for primary care
O'Connor P, Molde S, Henry S, Shockcor W, Schottenfeld R. Human immunodeficiency virus infection in intravenous drug users: A model for primary care. The American Journal Of Medicine 1992, 93: 382-386. PMID: 1415300, DOI: 10.1016/0002-9343(92)90166-9.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionPrimary careTuberculosis prophylaxisSyphilis treatmentVirus infectionDrug treatmentDrug usersPneumocystis carinii pneumonia prophylaxisHepatitis B vaccinePrimary care clinicsPrimary care servicesT-cell testingEligible patientsPneumonia prophylaxisAntiretroviral therapyB vaccineChart reviewPneumococcal vaccineT helperHIV infectionInfluenza vaccineCare clinicsMethadone maintenance