2016
Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction
Gandhi PU, Chow SL, Rector TS, Krum H, Gaggin HK, McMurray JJ, Zile MR, Komajda M, McKelvie RS, Carson PE, Januzzi JL, Anand IS. Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction. Journal Of Cardiac Failure 2016, 23: 20-28. PMID: 27317843, DOI: 10.1016/j.cardfail.2016.06.006.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-binding protein 7Heart failureCause mortalityPrimary outcomeEjection fractionHF eventsInsulin-like growth factorEjection Fraction trialGlomerular filtration rateSigns/symptomsProtein 7Binding protein 7Cardiovascular eventsMultivariable adjustmentSecondary outcomesCardiovascular hospitalizationPrognostic valueFiltration ratePrognostic meritTreatment groupsGrowth factorOutcomesFurther studiesPatientsEGFR
2015
Concentrations of Highly Sensitive Cardiac Troponin-I Predict Poor Cardiovascular Outcomes and Adverse Remodeling in Chronic Heart Failure
Motiwala SR, Gaggin HK, Gandhi PU, Belcher A, Weiner RB, Baggish AL, Szymonifka J, Januzzi JL. Concentrations of Highly Sensitive Cardiac Troponin-I Predict Poor Cardiovascular Outcomes and Adverse Remodeling in Chronic Heart Failure. Journal Of Cardiovascular Translational Research 2015, 8: 164-172. PMID: 25777344, DOI: 10.1007/s12265-015-9618-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersChi-Square DistributionChronic DiseaseDisease ProgressionFemaleHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardiumNatriuretic Peptide, BrainNecrosisOdds RatioPeptide FragmentsPhenotypePredictive Value of TestsPrognosisProportional Hazards ModelsRandomized Controlled Trials as TopicRetrospective StudiesRisk FactorsSystoleTime FactorsTroponin IVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsLV systolic dysfunctionChronic heart failureHeart failureLV remodelingSerial measurementsHigh-risk clinical featuresLower CV event ratesCV event ratesDeleterious LV remodelingIndependent risk informationPoor cardiovascular outcomesPoor CV outcomesProgressive LV remodelingSensitive cardiac troponinMajority of patientsSignificant myocardial necrosisSensitive troponin assaysPg/mLCV outcomesHsTnI concentrationsCardiovascular eventsCardiovascular outcomesSystolic dysfunctionAdverse remodelingClinical features
2014
Design, methods, baseline characteristics and interim results of the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study
Gaggin H, Bhardwaj A, Belcher A, Motiwala S, Gandhi P, Simon M, Kelly N, Anderson A, Garasic J, Danik S, Schwamm L, Gerszten R, van Kimmenade R, Januzzi J. Design, methods, baseline characteristics and interim results of the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study. IJC Metabolic & Endocrine 2014, 5: 11-18. DOI: 10.1016/j.ijcme.2014.08.005.Peer-Reviewed Original ResearchAcute kidney injuryEnd pointRenal complicationsMajor adverse cardiovascular eventsProspective single-center trialLong-term adverse outcomesPeripheral arterial complicationsPeri-procedural eventsAdverse cardiovascular eventsCombined end pointPeri-procedural complicationsPrimary end pointSecondary end pointsChronic kidney diseaseSingle-center trialNumber of patientsIndividual end pointsCardiovascular Disease StudyArterial complicationsAngiographic characteristicsCardiovascular eventsKidney injuryBaseline characteristicsNeurological eventsRenal biomarkersCharacterization and Prediction of Adverse Events From Intensive Chronic Heart Failure Management and Effect on Quality of Life: Results From the Pro-B-Type Natriuretic Peptide Outpatient-Tailored Chronic Heart Failure Therapy (PROTECT) Study
Gandhi PU, Szymonifka J, Motiwala SR, Belcher AM, Januzzi JL, Gaggin HK. Characterization and Prediction of Adverse Events From Intensive Chronic Heart Failure Management and Effect on Quality of Life: Results From the Pro-B-Type Natriuretic Peptide Outpatient-Tailored Chronic Heart Failure Therapy (PROTECT) Study. Journal Of Cardiac Failure 2014, 21: 9-15. PMID: 25463415, DOI: 10.1016/j.cardfail.2014.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersCardiovascular AgentsChronic DiseaseDisease ManagementDizzinessFemaleHeart FailureHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsPredictive Value of TestsProspective StudiesQuality of LifeRenal InsufficiencySurveys and QuestionnairesTreatment OutcomeConceptsTreatment-related serious adverse eventsSerious adverse eventsQuality of lifeAdverse eventsRisk scoreN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideChronic heart failure managementHeart Failure Questionnaire scoreWorse QOLAcute renal failureFirst cardiovascular eventHeart failure managementHeart failure therapyWorse functional classHighest-risk quartileCare armHF careHF managementSystolic HFCardiovascular eventsNT-proBNPReverse remodelingFailure therapyRenal failurePrognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function?
Gandhi PU, Gaggin HK, Sheftel AD, Belcher AM, Weiner RB, Baggish AL, Motiwala SR, Liu PP, Januzzi JL. Prognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function? The American Journal Of Cardiology 2014, 114: 1543-1549. PMID: 25248814, DOI: 10.1016/j.amjcard.2014.08.018.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersDisease ProgressionEchocardiography, DopplerFemaleFollow-Up StudiesHeart Failure, DiastolicHumansInsulin-Like Growth Factor Binding ProteinsMaleMiddle AgedMyocardial ContractionPrognosisProspective StudiesSeverity of Illness IndexStroke VolumeTime FactorsVentricular Function, LeftConceptsInsulin-like growth factor-binding protein 7Right ventricular systolic pressureReduced ejection fractionAtrial volume indexVentricular systolic pressureTransmitral E/Diastolic functionIGFBP7 concentrationsHeart failureEjection fractionSystolic pressureVolume indexEchocardiographic parametersHigher left atrial volume indexLeft atrial volume indexInsulin-like growth factorAmbulatory heart failureAbnormal diastolic functionMyocardial diastolic functionNovel prognostic biomarkerProtein 7Binding protein 7Echocardiographic abnormalitiesFinal echocardiogramCardiovascular events