2024
Associations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments
Wallach J, Yoon S, Doernberg H, Glick L, Ciani O, Taylor R, Mooghali M, Ramachandran R, Ross J. Associations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments. JAMA 2024, 331: 1646-1654. PMID: 38648042, PMCID: PMC11036312, DOI: 10.1001/jama.2024.4175.Peer-Reviewed Original ResearchConceptsMeta-analysesChronic diseasesFood and Drug AdministrationMeta-regression analysisMeta-analyses of observational studiesSurrogate markerClinical outcomesClinical trialsMeta-analysisEvidence of associationPublished meta-analysesStrength of associationMeta-analyses of clinical trialsChronic disease treatmentFood and Drug Administration tableResults of meta-regression analysisOutcome pairsFood and Drug Administration approvalMain OutcomesData extractionSystematic reviewStatistically significant resultsObservational studyPooled analysisDrug Administration108TiP CINDERELLA clinical trial: Using artificial intelligence-driven healthcare to enhance breast cancer locoregional treatment decisions
Pfob A, Bonci E, Kaidar-Person O, Antunes M, Ciani O, Cruz H, Di Micco R, Gentilini O, Heil J, Kabata P, Romariz M, Gonçalves T, Martins H, Borsoi L, Mika M, Romem N, Schinköthe T, Silva G, Bobowicz M, Cardoso M. 108TiP CINDERELLA clinical trial: Using artificial intelligence-driven healthcare to enhance breast cancer locoregional treatment decisions. ESMO Open 2024, 9: 103179. DOI: 10.1016/j.esmoop.2024.103179.Peer-Reviewed Original Research
2023
Surrogate endpoints: a key concept in clinical epidemiology
Christensen R, Ciani O, Manyara A, Taylor R. Surrogate endpoints: a key concept in clinical epidemiology. Journal Of Clinical Epidemiology 2023, 167: 111242. PMID: 38142762, DOI: 10.1016/j.jclinepi.2023.111242.Peer-Reviewed Original ResearchPatient-important outcomesSurrogate endpointsClinical outcomesTrue clinical outcomeClinical trialsClinical epidemiologyRobust scientific evidenceHealth outcomesIntermediate outcomesEndpointMeaningful cutoffsScientific evidenceOutcomesTreatment effectsPatientsInterventionSpecific changesRigorous evaluationEpidemiologyTrialsBiomarkers