1990
Direct carbon versus proton heteronuclear editing of 2‐13C ethanol in rabbit brain in vivo: A sensitivity comparison
Novotny E, Ogino T, Rothman D, Petroff O, Prichard J, Shulman R. Direct carbon versus proton heteronuclear editing of 2‐13C ethanol in rabbit brain in vivo: A sensitivity comparison. Magnetic Resonance In Medicine 1990, 16: 431-443. PMID: 2077334, DOI: 10.1002/mrm.1910160310.Peer-Reviewed Original ResearchProton NMR Observation of Phenylalanine and an Aromatic Metabolite in the Rabbit Brain in Vivo
Avison M, Herschkowitz N, Novotny E, Petroff O, Rothman D, Colombo J, Bachmann C, Shulman R, Prichard J. Proton NMR Observation of Phenylalanine and an Aromatic Metabolite in the Rabbit Brain in Vivo. Pediatric Research 1990, 27: 566-570. PMID: 2162514, DOI: 10.1203/00006450-199006000-00005.Peer-Reviewed Original ResearchNeonatal Excitotoxic Brain Injury
Young R, Petroff O, Novotny E, Wong M. Neonatal Excitotoxic Brain Injury. Developmental Neuroscience 1990, 12: 210-220. PMID: 2142073, DOI: 10.1159/000111850.Peer-Reviewed Original ResearchConceptsQuisqualic acidBrain injuryNeonatal excitotoxic brain injuryExcitotoxic brain injuryHypoxic-ischemic injuryNeonatal rat brainN-acetyl aspartateExcitotoxic damageNeuronal necrosisNeuropathologic examinationParoxysmal dischargesNeonatal ratsElectroencephalographic monitoringHilar areaRat brainMedial CA1Pathologic alterationsMetabolic alterationsParahippocampal regionPathological effectsGlutamate analogueInjuryPhysiologicUnique patternAlterationsIn Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy
Petroff O, Novotny E, Ogino T, Avison M, Prichard J. In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy. Journal Of Neurochemistry 1990, 54: 1188-1195. PMID: 2313285, DOI: 10.1111/j.1471-4159.1990.tb01947.x.Peer-Reviewed Original ResearchConceptsMagnetic resonance spectroscopyResonance spectroscopyChemical Shift Selective Magnetic Resonance ImagingVivo 1H magnetic resonance spectroscopyCerebral blood flowBlood ethanol concentrationVivo 1H spectroscopyMagnetic resonance imagingIntragastric administrationBlood flowGas chromatographyRabbit brainResonance imagingSpectroscopyPerchloric acid extractsEthanol levelsAdministrationBrainAcid extractsVivo measurementsCerebralEthanol concentration
1989
Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters
Ment L, Stewart W, Petroff O, Duncan C, Montoya D. Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters. Pediatric Neurology 1989, 5: 281-286. PMID: 2553028, DOI: 10.1016/0887-8994(89)90018-0.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonist MK801Cerebral blood flowBlood flowPerinatal asphyxiaCerebral high-energy phosphatesN-methyl-D-aspartate receptorsSaline 15 minBeagle puppy modelModel of ischemiaNewborn beagle puppiesHigh-energy phosphatesNeuropathologic damageAsphyxial insultPuppy modelNeuronal changesCerebral lactateExcitatory neurotransmitterBrainstem structuresPhosphocreatine levelsDrug treatmentMetabolic insultsBeagle puppiesMK801InsultPuppiesThromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedullaThe Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study
Young R, Chen B, Petroff O, Gore J, Cowan B, Novotny E, Wong M, Zuckerman K. The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study. Pediatric Research 1989, 25: 27-31. PMID: 2919113, DOI: 10.1203/00006450-198901000-00006.Peer-Reviewed Original ResearchConceptsBrain lactateBrain high-energy phosphatesArrest of seizuresFlurothyl-induced seizuresCerebral blood flowNormalization of EEGEffects of diazepamVivo 31P nuclear magnetic resonance spectroscopyHigh-energy phosphatesElectrographic seizuresNeonatal seizuresNeonatal dogsPostictal periodBrain pHBaseline valuesBlood flowBrain phosphocreatineMetabolic recoveryProlonged elevationSeizuresSustained increaseVivo 31PRapid returnDiazepamEnergy phosphates
1988
Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain.
C. Petroff O, Prichard J, Ogino T, Shulman R. Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain. Neurology 1988, 38: 1569-74. PMID: 3419601, DOI: 10.1212/wnl.38.10.1569.Peer-Reviewed Original ResearchConceptsBlood glucoseCerebral lactate accumulationLactate accumulationProton magnetic resonance spectroscopic studyWet weight/minCerebral metabolismCardiac arrestControl rabbitsRabbit brainGlycolytic rateMagnetic resonance spectroscopic measurementsCarbohydrate metabolismEquivalents/RabbitsMagnetic resonance spectroscopyMetabolismGlucoseCarbohydrate availabilityGlucose equivalent/High‐Resolution Proton Magnetic Resonance Spectroscopy of Rabbit Brain: Regional Metabolite Levels and Postmortem Changes
Petroff O, Ogino T, Alger J. High‐Resolution Proton Magnetic Resonance Spectroscopy of Rabbit Brain: Regional Metabolite Levels and Postmortem Changes. Journal Of Neurochemistry 1988, 51: 163-171. PMID: 3379399, DOI: 10.1111/j.1471-4159.1988.tb04850.x.Peer-Reviewed Original ResearchConceptsN-acetylaspartateWhite matterRabbit cerebral cortexCerebral white matterProton magnetic resonance spectroscopyGamma-aminobutyric acidRegional metabolite levelsTotal creatine poolCardiac arrestCerebral cortexCerebral metabolitesRabbit brainMagnetic resonance spectroscopyCreatine poolMetabolite levelsReference standardPostmortem changesCortexResonance spectroscopy1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia
Petroff O, Young R, Cowan B, Novotny E. 1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia. Pediatric Neurology 1988, 4: 31-34. PMID: 3233106, DOI: 10.1016/0887-8994(88)90021-5.Peer-Reviewed Original ResearchConceptsHigh-energy phosphatesBrain high-energy phosphatesBrain energy stateHypoglycemic brain damageInsulin-induced hypoglycemiaExcitatory amino acidsHypoglycemic brain injuryBrain tissue injuryMagnetic resonance spectroscopy studyAdult experimental animalsBrain glucose contentNeonatal hypoglycemiaExcitatory neurotransmitterInhibitory neurotransmitterMechanisms of resistanceNeonatal dogsBrain damageBrain injuryBrain glutamateTissue injuryEnergy failureNeonatal animalsGABA concentrationExperimental animalsHypoglycemiaBiological 1H NMR spectroscopy
Petroff O. Biological 1H NMR spectroscopy. Comparative Biochemistry And Physiology Part B Comparative Biochemistry 1988, 90: 249-260. PMID: 3044689, DOI: 10.1016/0305-0491(88)90069-7.Peer-Reviewed Original ResearchConceptsProton nuclear magnetic resonance spectroscopyNuclear magnetic resonance spectroscopyRecent biological applicationsPowerful analytical methodMagnetic resonance spectroscopyNMR spectroscopyNMR methodsRate of metabolismBiological applicationsMetabolic fluxResonance spectroscopyChemical compoundsComplex mixturesAbnormal physiological conditionsNMRCompoundsSpectroscopyAnalytical methodPhysiological conditionsExogenous compoundsIntracellular pHBody fluidsMetabolismMetabolic pathophysiologyMagnetization transfer
1987
Cerebral Lactate Elevation by Electroshock: A 1H Magnetic Resonance Studya
PRICHARD J, PETROFF O, OGINO T, SHULMAN R. Cerebral Lactate Elevation by Electroshock: A 1H Magnetic Resonance Studya. Annals Of The New York Academy Of Sciences 1987, 508: 54-63. PMID: 3439712, DOI: 10.1111/j.1749-6632.1987.tb32894.x.Peer-Reviewed Original ResearchIn vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure
Young R, Cowan B, Petroff O, Novotny E, Dunham S, Briggs R. In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure. Annals Of Neurology 1987, 22: 622-628. PMID: 3426168, DOI: 10.1002/ana.410220511.Peer-Reviewed Original ResearchConceptsNeonatal seizuresBrain energy stateBicuculline-induced seizuresBrain glucose concentrationsCerebral blood flowBeta-hydroxybutyrate levelsBrain metabolic stateVivo 31P nuclear magnetic resonance spectroscopyBrain alanineAdenosine triphosphate levelsNeonatal dogsPhosphocreatine levelsSignificant elevationBlood flowSeizuresMagnetic resonance spectroscopyBrain extractsVivo 31PHypoglycemiaAdverse effectsTriphosphate levelsGlucose concentrationGreater declineFurther deteriorationMetabolic state31P magnetization transfer studies of creatine kinase kinetics in living rabbit brain
Degani H, Alger J, Shulman R, Petroff O, Prichard J. 31P magnetization transfer studies of creatine kinase kinetics in living rabbit brain. Magnetic Resonance In Medicine 1987, 5: 1-12. PMID: 3657491, DOI: 10.1002/mrm.1910050102.Peer-Reviewed Original ResearchProton magnetic resonance spectroscopy of leech muscle and nervous system
Petroff O, Hogan E, Johansen J, Kleinhaus A. Proton magnetic resonance spectroscopy of leech muscle and nervous system. Comparative Biochemistry And Physiology Part B Comparative Biochemistry 1987, 87: 927-931. PMID: 3665438, DOI: 10.1016/0305-0491(87)90414-7.Peer-Reviewed Original ResearchConceptsMagnetic resonance spectroscopyProton nuclear magnetic resonance spectroscopyNuclear magnetic resonance spectroscopyResonance spectroscopyNMR spectroscopySpectroscopyMammalian cerebrumOrganic metabolitesIntracellular metabolitesNervous systemVentral cordPerchloric acid extractsMajor intracellular metaboliteSpectraNervous tissueAspartateAminobutyric acidRapid meansAcid extractsMetabolitesHirudonineInositolRabbit cerebrumAlanineDistinctive components
1986
Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose
Behar K, Petroff O, Prichard J, Alger J, Shulman R. Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose. Magnetic Resonance In Medicine 1986, 3: 911-920. PMID: 2881185, DOI: 10.1002/mrm.1910030611.Peer-Reviewed Original ResearchCombined 1H and 31P nuclear magnetic resonance spectroscopic studies of bicuculline‐induced seizures in vivo
Petroff O, Prichard J, Ogino T, Avison M, Alger J, Shulman R. Combined 1H and 31P nuclear magnetic resonance spectroscopic studies of bicuculline‐induced seizures in vivo. Annals Of Neurology 1986, 20: 185-193. PMID: 3752964, DOI: 10.1002/ana.410200203.Peer-Reviewed Original ResearchConceptsBicuculline-induced seizuresCerebral intracellular pHArterial blood pressureCerebral lactate levelsIntracellular pHLactate elevationProlonged seizuresBlood pressureParalyzed rabbitsLactate levelsHeart rateSeizuresLactate concentrationComplete recoverySigns of recoveryElectroencephalogramHoursCerebrumMagnetic resonance spectroscopic studiesBrain
1985
Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies.
Petroff O, Prichard J, Behar K, Rothman D, Alger J, Shulman R. Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies. Neurology 1985, 35: 1681-8. PMID: 2933595, DOI: 10.1212/wnl.35.12.1681.Peer-Reviewed Original ResearchCerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy.
Petroff O, Prichard J, Behar K, Alger J, den Hollander J, Shulman R. Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology 1985, 35: 781-8. PMID: 4000479, DOI: 10.1212/wnl.35.6.781.Peer-Reviewed Original ResearchEffect of Hypoglycemic Encephalopathy upon Amino Acids, High‐Energy Phosphates, and pHi in the Rat Brain In Vivo: Detection by Sequential 1H and 31P NMR Spectroscopy
Behar K, Hollander J, Petroff O, Hetherington H, Prichard J, Shulman R. Effect of Hypoglycemic Encephalopathy upon Amino Acids, High‐Energy Phosphates, and pHi in the Rat Brain In Vivo: Detection by Sequential 1H and 31P NMR Spectroscopy. Journal Of Neurochemistry 1985, 44: 1045-1055. PMID: 2857770, DOI: 10.1111/j.1471-4159.1985.tb08723.x.Peer-Reviewed Original Research