2001
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
Krause D, Theise N, Collector M, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis S. Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell. Cell 2001, 105: 369-377. PMID: 11348593, DOI: 10.1016/s0092-8674(01)00328-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Antigens, LyBone Marrow CellsCell LineageCell MovementEpithelial CellsFemaleFluorescent DyesHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansImmunohistochemistryIn Situ Hybridization, FluorescenceIntestine, SmallKeratinsLungMaleMembrane ProteinsMiceMice, KnockoutOrganic ChemicalsPulmonary SurfactantsStem CellsY ChromosomeConceptsLong-term repopulationSingle bone marrowMulti-lineage engraftmentAdult bone marrow cellsProperties of HSCHematopoietic stemSecondary hostsGenetic diseasesStem cellsBone marrow cellsExpression increasesDifferentiative capacityBone marrowEpithelial cellsSerial transplantationRare cellsTissue repairMarrow cellsCellsDifferentiationHostSecondary recipientsGI tractPhenotypeMarrow
2000
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
Shao C, Deng L, Henegariu O, Liang L, Stambrook P, Tischfield J. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7405-7410. PMID: 10861008, PMCID: PMC16558, DOI: 10.1073/pnas.97.13.7405.Peer-Reviewed Original ResearchConceptsGenetic instabilityChromosome instabilityP53-null miceP53 tumor suppressor proteinMultiple cellular processesCell cycle checkpointsTumor suppressor proteinSomatic cell variantsNormal cellsNull miceCellular processesCycle checkpointsGenetic variationMitotic recombinationSuppressor proteinEpigenetic alterationsInterstitial deletionLOH eventsCell deathLoss of heterozygosityP53 functionFibroblast coloniesPoint mutationsFunctional p53Tumor initiation