Nikolay Peter Gresko, MD, PhD
Associate Research Scientist of Cellular and Molecular PhysiologyDownloadHi-Res Photo
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Associate Research Scientist of Cellular and Molecular Physiology
Appointments
Cellular & Molecular Physiology
Associate Research ScientistPrimary
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Education & Training
- PhD
- University of Zurich (2011)
- MD
- Russian State Medical University of Moscow (2005)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Nikolay Peter Gresko's published research.
Publications Timeline
A big-picture view of Nikolay Peter Gresko's research output by year.
Hongying Shen, PhD
Ke Dong, MD, MS
Michael Caplan, PhD, MD
Raj Pandya
Stefan Somlo, MD
TuKiet Lam, PhD, BS
5Publications
439Citations
Publications
2023
The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion
Onuchic L, Padovano V, Schena G, Rajendran V, Dong K, Shi X, Pandya R, Rai V, Gresko N, Ahmed O, Lam T, Wang W, Shen H, Somlo S, Caplan M. The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion. Nature Communications 2023, 14: 1790. PMID: 36997516, PMCID: PMC10063565, DOI: 10.1038/s41467-023-37449-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPolycystin-1Nicotinamide nucleotide transhydrogenaseTerminal tailCystic phenotypeAutosomal dominant polycystic kidney diseaseCyst cell proliferationC-terminal domainAmino acid residuesLethal monogenic disorderC-terminal cleavageNucleotide transhydrogenaseAcid residuesMitochondrial functionTransgenic expressionPKD1 geneRedox stateShort fragmentsCell proliferationMonogenic disordersDominant polycystic kidney diseasePolycystic kidney diseaseGene therapy strategiesProteinPhenotypeFragments
2013
Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice
Sorensen M, Grossmann S, Roesinger M, Gresko N, Todkar A, Barmettler G, Ziegler U, Odermatt A, Loffing-Cueni D, Loffing J. Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney International 2013, 83: 811-824. PMID: 23447069, DOI: 10.1038/ki.2013.14.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdministration, OralAldosteroneAnimalsBiological TransportCytochrome P-450 CYP11B2Epithelial Sodium ChannelsFemaleKidneyMaleMiceMice, Inbred C57BLMice, KnockoutNatriuresisPhosphorylationPotassium, DietaryReceptors, DrugSolute Carrier Family 12, Member 3SymportersTime FactorsWater-Electrolyte BalanceConceptsNaCl cotransporterPotassium loadAcute oral potassium loadOral potassium loadRenal potassium excretionUrinary sodium lossPlasma potassium concentrationDietary potassium loadSodium chloride cotransporterRenal sodium chloride cotransporterPlasma AldoAldosterone levelsSodium excretionNatriuretic effectPotassium excretionUrinary potassiumPotassium intakeEpithelial sodium channelGastric gavagePlasma potassiumSpot urineDistal nephronIntraluminal sodiumFunctional changesChloride cotransporter
2012
Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney
Lier N, Gresko N, Di Chiara M, Loffing-Cueni D, Loffing J. Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney. Histochemistry And Cell Biology 2012, 138: 101-112. PMID: 22466139, DOI: 10.1007/s00418-012-0944-1.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsIntracellular traffickingRab-GTPase activating proteinInsulin-dependent traffickingParietal epithelial cellsRenal transport proteinsExtracellular fluid homeostasisGlucose transporter GLUT4Epithelial sodium channel ENaCDeficient miceImmunohistochemical studyRabbit polyclonal antibodySkeletal muscle cellsBowman's capsuleWater channel AQP2Proximal tubulesRenal ionSpecific marker proteinsKidney homogenatesHenle's loopSodium channel ENaCFluid homeostasisThick limbMuscle cellsMouse kidney homogenatesMouse kidney
2010
In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule
Ackermann D, Gresko N, Carrel M, Loffing-Cueni D, Habermehl D, Gomez-Sanchez C, Rossier B, Loffing J. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. American Journal Of Physiology. Renal Physiology 2010, 299: f1473-f1485. PMID: 20861076, DOI: 10.1152/ajprenal.00437.2010.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAldosterone-sensitive distal nephronThick ascending limbGlucocorticoid receptorLate distal convoluted tubuleLow-dose corticosterone replacementSegment-specific cellsNuclear translocationDietary NaCl loadingDistal convoluted tubuleKidneys of ratsDehydrogenase type 2Proximal tubule cellsAldosterone replacementMineralocorticoid selectivityPlasma aldosteroneCorticosteroid effectsCorticosterone replacementControl ratsDistal tubulesDistal nephronConvoluted tubulesNaCl loadingCorticosterone levelsAscending limbHigh doses
2008
Role of Golgi apparatus and microtubules for aldosterone and vasopressin–dependent regulation of ENaC activity
Gresko N, Rossier B, Loffing J. Role of Golgi apparatus and microtubules for aldosterone and vasopressin–dependent regulation of ENaC activity. The FASEB Journal 2008, 22: 1201.22-1201.22. DOI: 10.1096/fasebj.22.1_supplement.1201.22.Peer-Reviewed Original Research
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Sterling Hall of Medicine, B-Wing
333 Cedar Street
New Haven, CT 06510