2021
Perianeurysmal retroperitoneal fibrosis presenting as acute kidney injury: A case report.
Hodson DZ, Cantley LG, Perincheri S, Singh N. Perianeurysmal retroperitoneal fibrosis presenting as acute kidney injury: A case report. Clinical Nephrology 2021, 96: 112-119. PMID: 34142944, DOI: 10.5414/cn110331.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injuryKidney injuryChronic periaortitisRenal functionRetroperitoneal fibrosisLong-term renal functionRetroperitoneal soft tissue massPerianeurysmal retroperitoneal fibrosisAcute tubular injuryLong-term sequelaeBilateral nephrostomy tubesInfrarenal abdominal aortaSoft tissue massBilateral uretersRenal ultrasoundCommon complicationOlder patientsRenal failureTubular injuryUltrasonographic evidenceUncommon causeRenal biopsyRenal sonographyFirst admissionObstructive nephropathy
2019
Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry
Singh N, Avigan ZM, Kliegel JA, Shuch BM, Montgomery RR, Moeckel GW, Cantley LG. Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry. JCI Insight 2019, 4: e129477. PMID: 31217358, PMCID: PMC6629112, DOI: 10.1172/jci.insight.129477.Peer-Reviewed Original ResearchConceptsCell typesIndividual cell typesCritical baseline dataRenal cell typesMass cytometryQuantitative atlasNormal human samplesHuman kidneyRelative abundanceDevelopment of therapiesHuman kidney diseaseKidney diseaseMetal-conjugated antibodiesQuantitative interrogationScarce samplesMachine-learning pipelineDiscovery purposesFuture quantitative analysisNovel abnormalityNormal human kidneySingle tissue sectionHuman samplesRenal biopsyImmune cellsCellsUrine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis
Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney diseasePrebiopsy diagnosisKidney biopsyKidney diseaseIL-9AIN diagnosisUrine TNFInterstitial nephritisSpecific T cell subsetsAcute tubular injuryDiabetic kidney diseaseIL-9 levelsTNF-α levelsT cell subsetsAddition of biomarkersPlasma cytokinesCytokine levelsTubular injuryHighest quartileMultivariable analysisCell subsetsUrinary TNFBlood eosinophilsGlomerular disease
2011
Histone Deacetylase 3 Regulates Smooth Muscle Differentiation in Neural Crest Cells and Development of the Cardiac Outflow Tract
Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone Deacetylase 3 Regulates Smooth Muscle Differentiation in Neural Crest Cells and Development of the Cardiac Outflow Tract. Circulation Research 2011, 109: 1240-1249. PMID: 21959220, PMCID: PMC3225257, DOI: 10.1161/circresaha.111.255067.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal MedullaAnimalsAorta, ThoracicCell DifferentiationCell LineageCell MovementDouble Outlet Right VentricleFemaleFetal HeartGene Expression Regulation, DevelopmentalHeart Defects, CongenitalHeart Septal Defects, VentricularHeart VentriclesHistone DeacetylasesMaleMiceMice, TransgenicMuscle, SmoothNeural CrestPaired Box Transcription FactorsPAX3 Transcription FactorReceptors, NotchThymus GlandWnt1 ProteinConceptsNeural crest cellsCardiac outflow tractMuscle differentiationSmooth muscle differentiationCrest cellsCardiac neural crest developmentMultiple progenitor cell populationsFunctions of Hdac3Loss of Hdac3Neural crest cell migrationNeural crest developmentSmooth muscle lineageCrest cell migrationNumerous signaling pathwaysHistone deacetylase 3Role of epigeneticsProgenitor cell populationsSpecific regulatory roleNeural crest derivativesNotch ligand Jagged1OFT formationNeural crest resultsMammalian developmentMuscle lineageEpigenetic regulation