Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsNicolas Gaspard, PhD
Assistant Professor AdjunctAbout
Research
Publications
2025
Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation
Moreau A, Su F, Ferlini L, Gaspard N, Pischiutta F, Zanier E, Creteur J, Annoni F, Taccone F. Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation. Intensive Care Medicine Experimental 2025, 13: 127. PMID: 41396233, PMCID: PMC12705496, DOI: 10.1186/s40635-025-00841-w.Peer-Reviewed Original ResearchReturn of spontaneous circulationExtracorporeal cardiopulmonary resuscitationConventional cardiopulmonary resuscitationNeuron-specific enolaseGlial fibrillary acidic proteinCardiopulmonary resuscitationIntracardiac injectionIntracardiac injection of potassium chlorideTreated with extracorporeal cardiopulmonary resuscitationCirculating BiomarkersAchievement of return of spontaneous circulationExtracorporeal membrane oxygenation supportIntracranial pressureEffect of therapeutic hypothermiaHypoxic-ischemic brain injuryVeno-arterial extracorporeal membrane oxygenation supportInjection of potassium chlorideLong-term neurological disabilityMembrane oxygenation supportControlled experimental modelImpact of hypothermiaCardiac arrest modelUntreated ventricular fibrillationCause of mortalityBrain tissueDisorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable
Bodien Y, Busl K, Chang C, Claassen J, Gaspard N, Gosseries O, Helbok R, Massimini M, Naccache L, Newcombe V, Robba C, Rohaut B, Suarez J, Turgeon A, Vespa P, Wahlster S, Taccone F, Citerio G. Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable. Intensive Care Medicine 2025, 1-21. PMID: 41396553, DOI: 10.1007/s00134-025-08224-1.Peer-Reviewed Original ResearchEvidence-informed guidanceCritical care environmentClinical managementClinical management of patientsTrajectory of recoverySpectrum of clinical conditionsManagement of patientsCare environmentEmergency medicineFunctional neuroimagingDisorders of consciousnessDisorder of consciousness diagnosisMinimally conscious stateExpert cliniciansLevel of consciousnessBlood-based biomarkersClinical conditionsBrain injuryIntensive careClinical translationWakefulness syndromeConfoundingPatientsDiagnosisInterventionPrognostic significance of post-anoxic myoclonus: time for a reappraisal?
De Stefano P, Leitinger M, Quintard H, Trinka E, Gaspard N. Prognostic significance of post-anoxic myoclonus: time for a reappraisal? Resuscitation 2025, 217: 110896. PMID: 41237842, DOI: 10.1016/j.resuscitation.2025.110896.Peer-Reviewed Original ResearchModified 2HELPS2B Score Predicts Failure to Wean From Anesthetics in Refractory and Super-Refractory Status Epilepticus
Matteo E, Damien C, Torcida Sedano N, Legros B, Gaspard N. Modified 2HELPS2B Score Predicts Failure to Wean From Anesthetics in Refractory and Super-Refractory Status Epilepticus. Neurology Clinical Practice 2025, 15: e200550. PMID: 41221027, PMCID: PMC12598878, DOI: 10.1212/cpj.0000000000200550.Peer-Reviewed Original ResearchSingle-center retrospective case-control studyStatus epilepticusElectrographic seizuresAssociated with successful weaningSuper-refractory status epilepticusAssociated with status epilepticusRefractory status epilepticusCritically ill patientsWeaning attemptsRefractory SESuccessful weaningIll patientsEEG variablesEpilepticusSuper-refractoryIntravenous anesthetic drugsPatientsSeizuresAnesthetic drugsScoresWeaningFailureRecurrenceTherapyAnestheticsFeatures, Outcome, and Treatment of Postanoxic Status Epilepticus
De Stefano P, Hofmeijer J, Quintard H, Damien C, Misirocchi F, Caroyer S, Horn J, Tromp S, Kornips B, Hilkman D, van Mook W, Hoedemaekers C, Annoni F, Legros B, Seeck M, Van Putten M, Gaspard N, investigators F. Features, Outcome, and Treatment of Postanoxic Status Epilepticus. Neurology 2025, 105: e214282. PMID: 40982774, DOI: 10.1212/wnl.0000000000214282.Peer-Reviewed Original ResearchQuality of life over time after new onset refractory status epilepticus
Gruen M, Gopaul M, Jimenez A, Batra A, Blank L, Damien C, Day G, Eschbach K, Gerard E, Gofton T, Hantus S, Jette N, Jongeling A, Kang P, Kazazian K, Kellogg M, Kim M, Madani B, Morales M, Punia V, Steriade C, Struck A, Taraschenko O, Torcida N, Wainwright M, Yoo J, Gaspard N, Wong N, Hirsch L, Hanin A. Quality of life over time after new onset refractory status epilepticus. Epilepsia 2025 PMID: 40944696, DOI: 10.1111/epi.18635.Peer-Reviewed Original ResearchQuality of lifeAssociations with poor quality of lifePoor quality of lifeMeasures of fatigueQoL-ISocial support strategiesReference populationAssociated with more depressionQuality of life improvementMultidisciplinary support systemQuality of life impairmentNeuro-QoLPerceived stigmaMulticenter prospective studySocial healthSocial rolesSupport strategiesPediatric participantsIntensive care unit stayCognitive difficultiesCognitive impairmentGreater improvementAcute episodeT-scoreAdultsStandard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study
Guillemaud M, Hanin A, Riviello J, Chavez M, Batra A, Berry M, Bisulli F, Castillo‐Pinto C, Cobos‐Hernandez C, Demeret S, Eschbach K, Farias‐Moeller R, Fields M, Gaspard N, Gerard E, Gofton T, Gopaul M, Gruen M, Jimenez A, Kazazian K, Kim M, Mansour M, Marcuse L, Marois C, Morales M, Muccioli L, Pasini E, Pham M, Rosas S, Struck A, Torcida N, Wainwright M, Yoo J, Muscal E, Navarro V, Hirsch L, Lai Y. Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study. Epilepsia 2025 PMID: 40844418, DOI: 10.1111/epi.18605.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeMonocyte-to-lymphocyte ratioNeutrophil-to-lymphocyte ratioComplete blood countNew-onset refractory status epilepticusSecond-line immunotherapyUnfavorable outcomeBlood countComplete blood count levelsHigh red cell distribution widthEpilepsy syndromesTreatment phaseFirst-line immunotherapyInitiation of immunotherapyRed cell distribution widthRefractory status epilepticusComplete blood count dataCell distribution widthLong-term outcomesIntensive care unitSubtypes of leukocytesLeave-one-patient-outMulticenter studyStatus epilepticusImmunotherapyFeatures, Outcome, and Treatment of Postanoxic Status Epilepticus
De Stefano P, Hofmeijer J, Quintard H, Damien C, Misirocchi F, Caroyer S, Horn J, Tromp S, Kornips B, Hilkman D, van Mook W, Hoedemaekers C, Annoni F, Legros B, Seeck M, Van Putten M, Gaspard N, investigators F, Ruijter B, Keijzer H, Tjepkema-Cloostermans M, Blans M, Bosch F, Glimmerveen A, Beishuisen A, Eertman C, Tromp S, Scholten E, Seeber A, Teunissen L, Datema M, Noordzij P, Moeniralam H, Horn J, van Rootselaar A, Admiraal M, Velseboer D, Koelman J, van den Bergh W, Elting J, Drost G, Foudraine N, Kornips F, van Kranen-Mastenbroek V, Rouhl R, Hilkman D, Aries M, van Mook W, Vlooswijk M, Thomeer E, Moudrous W, Nijhuis F, Booij S, Bernsen H, Hoedemaekers C, Doorduin J, Taccone F, Gaspard N, van der Palen J, van Putten M, Hofmeijer J. Features, Outcome, and Treatment of Postanoxic Status Epilepticus. Neurology 2025, 105: e213913. PMID: 40720710, PMCID: PMC12296630, DOI: 10.1212/wnl.0000000000213913.Peer-Reviewed Original ResearchConceptsMulticenter pooled analysisStatus epilepticusCerebral Performance CategoryCardiac arrestGood outcomeSE cessationSE onsetHigh dosesHigher dose of levetiracetamMultivariate analysisPooled analysis of individual patient dataAnalysis of individual patient dataEEG predictorsAssociated with favorable outcomesPostanoxic status epilepticusAssociated with good recoveryDose of levetiracetamExclusion of patientsGroup of patientsIdentification of patientsPredictors of outcomeIndividual patient dataPrognostic significanceSE patientsCardiopulmonary resuscitation trialsThe SEDS score: A daily severity score for monitoring patients with refractory SE in the ICU
Damien C, Habryka S, Torcida N, Wang L, Legros B, Yuan F, Gaspard N. The SEDS score: A daily severity score for monitoring patients with refractory SE in the ICU. Seizure 2025, 131: 344-350. PMID: 40811895, DOI: 10.1016/j.seizure.2025.07.011.Peer-Reviewed Original ResearchConceptsRefractory status epilepticusWeek of intensive care unitArea under the receiver operating characteristic curveIntensive care unitSequential Organ Failure AssessmentIntensive care unit admissionDaily severity scoreValidation cohortDerivation cohortRSE episodesSeverity scoreSequential Organ Failure Assessment scoreOrgan Failure AssessmentTertiary-care centerRetrospective observational studyReceiver operating characteristic curveC-reactive proteinMann-Whitney testOperating characteristics curveRefractory SEPrognostic scoreSOFA scoreCRP levelsStatus epilepticusPoor outcomeBrain Connectivity for the Diagnosis of Epileptic Encephalopathy with Spike Wave Activation in Sleep (EE-SWAS) Syndrome
Cottin L, Van Gyseghem P, Sclavont Z, Aeby A, Gaspard N, Nonclercq A. Brain Connectivity for the Diagnosis of Epileptic Encephalopathy with Spike Wave Activation in Sleep (EE-SWAS) Syndrome. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2025, 00: 1-7. PMID: 41336876, DOI: 10.1109/embc58623.2025.11252846.Peer-Reviewed Original ResearchConceptsAwake electroencephalographyEpileptic encephalopathyDiagnosis of epileptic encephalopathySpike-wave indexSpike-wave activitySpike wave activityDiagnostic accuracy studiesCentro-temporal spikesFeature-basedNeurocognitive regressionSelf-limited focal epilepsiesAUC-ROCBrain connectivityNeurocognitive impairmentFocal epilepsyMultivariate modelAccuracy studiesAUC-ROC valuesNormal functionDiagnostic capabilitiesSleepEncephalopathyClustering coefficientDiscriminatory powerConnection mechanism