Featured Publications
Anticonvulsants
Popovitz E, Li J, Vadivelu N. Anticonvulsants. 2023, 139-146. DOI: 10.1007/978-3-031-21291-8_9.ChaptersDiabetic peripheral neuropathySpinal cord injuryPerioperative settingRole of anticonvulsantsHerpetic neuralgiaMultimodal analgesiaNeuropathic painSurgery protocolPeripheral neuropathyCord injuryPrimary medicationThoracic proceduresAssociated pathologyEnhanced recoveryAnalgesiaNeuropathyPainAnticonvulsantsOptimal dosageGabapentinoidsNeuralgiaMedicationsHIVGabapentinPregabalinAmbulatory Pain Management in the Pediatric Patient Population
Oliver JA, Oliver LA, Aggarwal N, Baldev K, Wood M, Makusha L, Vadivelu N, Lichtor L. Ambulatory Pain Management in the Pediatric Patient Population. Current Pain And Headache Reports 2022, 26: 15-23. PMID: 35129824, DOI: 10.1007/s11916-022-00999-y.Peer-Reviewed Original ResearchConceptsPain managementPostoperative painPediatric ambulatory surgical patientsPostoperative pain controlAmbulatory surgical patientsSevere postoperative painExtent of painPeripheral nerve blocksPediatric ambulatory surgeryPediatric patient populationNon-pharmacological techniquesRandomized control studyEvidence-based approachMultimodal analgesiaPain controlSurgical patientsNerve blockPediatric populationAmbulatory surgeryPatient populationMost centersControl studyPainScientific evidenceMultimodal approachWeaning Protocols After Ambulatory Surgery
Aggarwal N, Zafar J, Kodumudi G, Vadivelu N, Laurans M, Rajput K. Weaning Protocols After Ambulatory Surgery. 2021, 369-377. DOI: 10.1007/978-3-030-55262-6_28.ChaptersHospital-based outpatient departmentsAmbulatory surgery centersPostoperative painUnplanned admissionsAmbulatory surgeryLong-term opioid usersNumber of surgeriesUnanticipated admissionMultimodal analgesiaOpioid prescriptionsPain medicationPerioperative analgesiaIntractable nauseaOutpatient departmentOpioid usersAmbulatory proceduresSurgery centersWeaning protocolHospital careOrthopedic proceduresSurgeryPainPatientsAdmissionMajor cause
2016
Role of Alternative Therapies for Chronic Pain Syndromes
Thomas DA, Maslin B, Legler A, Springer E, Asgerally A, Vadivelu N. Role of Alternative Therapies for Chronic Pain Syndromes. Current Pain And Headache Reports 2016, 20: 29. PMID: 27038968, DOI: 10.1007/s11916-016-0562-z.Peer-Reviewed Original ResearchConceptsChronic painWhole-body cryotherapyExercise therapyPain statesAlternative therapiesComplimentary therapiesLong-term pain statesChronic pain syndromePhysical exercise therapyTreatment of headacheCognitive behavior therapyNeck painPain syndromeAlternate therapyBiofeedback therapyPain psychologySham controlsPainHerbal supplementsAlternative medicineTherapyBiopsychosocial approachBehavior therapyBiopsychosocial modelNew modalityEfficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control.
Thomas DA, West M, Legler A, Maslin B, Kim RK, Vadivelu N. Efficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control. Current Drug Safety 2016, 11: 196-205. PMID: 27113953, DOI: 10.2174/1574886311666160426130444.Peer-Reviewed Original ResearchConceptsPain controlNonopioid analgesicsSide effectsContemporary pain managementOptimum pain controlPerioperative pain controlAcute postoperative painPostoperative pain controlMultiple side effectsNonopioid medicationsPostoperative painTolerant patientsPain managementSafety profileAnalgesicsRecent dataComorbiditiesMedicationsOpioidsPainPatientsSurgeryMainstayControl
2015
Tapentadol extended release in the management of peripheral diabetic neuropathic pain
Vadivelu N, Kai A, Maslin B, Kodumudi G, Legler A, Berger JM. Tapentadol extended release in the management of peripheral diabetic neuropathic pain. Therapeutics And Clinical Risk Management 2015, Volume 11: 95-105. PMID: 25609974, PMCID: PMC4298300, DOI: 10.2147/tcrm.s32193.Peer-Reviewed Original ResearchPainful diabetic neuropathyDiabetic neuropathyOpioid-based therapyCancer-related painDiabetic neuropathic painChronic pain conditionsGastrointestinal side effectsNorepinephrine reuptake inhibitorsΜ-opioid agonistMechanism of actionNeuropathic painPain conditionsReuptake inhibitorsBack painArthritic painClinical efficacyEffective medicationsClinical studiesSide effectsPainTapentadolNeuropathyOne-thirdMedicationsDiabetes
2014
Intrathecal drug delivery for chronic pain management-scope, limitations and future
Czernicki M, Sinovich G, Mihaylov I, Nejad B, Kunnumpurath S, Kodumudi G, Vadivelu N. Intrathecal drug delivery for chronic pain management-scope, limitations and future. Journal Of Clinical Monitoring And Computing 2014, 29: 241-249. PMID: 25173564, DOI: 10.1007/s10877-014-9607-1.Peer-Reviewed Original ResearchConceptsIntrathecal drug delivery systemsChronic painOptimal medical managementIntrathecal drug deliveryDifferent implantation techniquesLicensing of drugsSevere morbidityMedical managementMuscle spasmMain indicationsIntrathecal useInvasive techniquesOutcome studiesPainAdverse effectsHealthcare practitionersImplantation techniqueTherapyDrug delivery systemsTherapy systemReview articleDelivery systemDate knowledgeMorbiditySpasmPerioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone.
Kaye AD, Alian AA, Vadivelu N, Chung KS. Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone. Journal Of Opioid Management 2014, 10: 69-72. PMID: 24604572, DOI: 10.5055/jom.2014.0194.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaHigh dosesHigh-dose opioidsCancer-related painPresent case reportMega dosesOpioid requirementsOpioid managementMetastatic leiomyosarcomaAgonist clonidineCase reportPotent analgesicOpioidsPatientsSuccessful managementDosesPainMethadoneMorphineHyperalgesiaClonidineAnalgesicsLeiomyosarcomaManagementAntagonistPractical guide to the management of acute and chronic pain in the presence of drug tolerance for the healthcare practitioner.
Vadivelu N, Singh-Gill H, Kodumudi G, Kaye AJ, Urman RD, Kaye AD. Practical guide to the management of acute and chronic pain in the presence of drug tolerance for the healthcare practitioner. Ochsner Journal 2014, 14: 426-33. PMID: 25249810, PMCID: PMC4171802.Peer-Reviewed Original ResearchPain managementDrug toleranceMultidisciplinary pain managementChronic pain statesMethadone maintenance programPain statesSupportive carePatient's painChronic painMedication diversionSubstance disordersUrine testingDrug interactionsDetailed historyPatientsPainPsychiatric conditionsTimely interventionPatient's addictionPrescription drugsSafe outcomeDrug abuseAddictive disordersHealthcare practitionersMedical observation
2013
Nociceptive Chemical Mediators in Oral Inflammation
Vadivelu N, Gowda A, Thorp S, Kai A, Vadivelu A, Dabu-Bondoc S. Nociceptive Chemical Mediators in Oral Inflammation. 2013, 25-33. DOI: 10.1007/978-3-319-01875-1_4.Peer-Reviewed Original ResearchThe Neurobiology of Orofacial Pain
Vadivelu N, Huang Y, Mancini P, Gruenbaum S, Vadivelu A, Dabu-Bondoc S. The Neurobiology of Orofacial Pain. 2013, 1-8. DOI: 10.1007/978-3-319-01875-1_1.Peer-Reviewed Original ResearchNeuropathic orofacial painOrofacial painFacial painTemporomandibular dysfunctionCostly health issueTrigeminal neuropathic painAtypical facial painPrimary afferent nociceptorsChronic facial painComplex multifactorial etiologyOrofacial syndromesNeuropathic painAfferent nociceptorsNeurologic pathwaysUnique pathophysiologyCerebral cortexOrofacial areaMultifactorial etiologyPainClinical diagnosisHealth issuesCentral relayNumerous recent advancesFinancial burdenSexual behaviorClinical applications of oxymorphone.
Vadivelu N, Maria M, Jolly S, Rosenbloom J, Prasad A, Kaye AD. Clinical applications of oxymorphone. Journal Of Opioid Management 2013, 9: 439-52. PMID: 24481932, DOI: 10.5055/jom.2013.0186.Peer-Reviewed Original ResearchConceptsNew oral preparationNew oral formulationSemisynthetic opioid analgesicSpecific side effectsSevere painOpioid analgesicsParenteral formClinical indicationsOral preparationsStudy populationPharmacological considerationsOral formulationSide effectsPatient needsUS FoodDrug AdministrationHealthcare providersParenteral formulationsClinical applicationPainImportant drugsOxymorphoneAdditional optionPyridomorphinansSpecific considerationsDiabetic neuropathy
Vadivelu N. Diabetic neuropathy. International Journal Of Nutrition Pharmacology Neurological Diseases 2013, 3: 332-334. DOI: 10.4103/2231-0738.119839.Peer-Reviewed Original ResearchDiabetic neuropathyNerve conduction testsPainful diabetic neuropathyLong-term diabetesFoot examsCentral sensitizationNerve damageSerious complicationsTerm diabetesCommon siteNeuropathyConduction testsDiabetesCell damageOxidative stressPainGene therapyTreatmentPlant extractsComplicationsPatientsTherapyDamageSensitization
2010
Fibromyalgia, Arthritic, and Myofascial Pain
Vadivelu N, Urman R. Fibromyalgia, Arthritic, and Myofascial Pain. 2010, 557-566. DOI: 10.1007/978-0-387-87579-8_25.ChaptersBuprenorphine in Postoperative Pain Management
Vadivelu N, Anwar M. Buprenorphine in Postoperative Pain Management. Anesthesiology Clinics 2010, 28: 601-609. PMID: 21074740, DOI: 10.1016/j.anclin.2010.08.015.Peer-Reviewed Original Research
2009
Pain Pathways and Acute Pain Processing
McQuay H, Vadivelu N, Whitney C, Sinatra R. Pain Pathways and Acute Pain Processing. 2009, 3-20. DOI: 10.1017/cbo9780511576706.003.ChaptersPain pathwaysPain managementAcute pain managementPatient-controlled analgesiaAcute pain processingRole of anesthesiologistsAnalgesic optionsPain serviceAcute painSevere painChronic painPain assessmentPain processingTherapeutic guidelinesOptimal carePainAnalgesiaPatientsChronicityPathophysiologyOptionsAnesthesiologistsCliniciansPathwayIncidence
2008
Management of chronic pain in the elderly: focus on transdermal buprenorphine
Vadivelu N, Hines RL. Management of chronic pain in the elderly: focus on transdermal buprenorphine. Clinical Interventions In Aging 2008, Volume 3: 421-430. PMID: 18982913, PMCID: PMC2682375, DOI: 10.2147/cia.s1880.Peer-Reviewed Original ResearchConceptsChronic painTransdermal buprenorphineSafety profileChronic cancer painChronic nonmalignant painNew treatment optionsRelative safety profileCancer painNonmalignant painRespiratory depressionRenal failureTreatment optionsAnalgesic agentsCeiling doseAnalgesic propertiesPainSide effectsClinical practiceBuprenorphineOlder individualsCeiling effectsMetabolic changesDose dumpingSafe useRecent scientific studiesArticle Commentary: Pain after Mastectomy and Breast Reconstruction
Vadivelu N, Schreck M, Lopez J, Kodumudi G, Narayan D. Article Commentary: Pain after Mastectomy and Breast Reconstruction. The American Surgeon 2008, 74: 285-296. PMID: 18453290, DOI: 10.1177/000313480807400402.Peer-Reviewed Original ResearchConceptsSentinel node biopsyBreast cancerBreast reconstructionNode biopsyEarly treatmentInvasive therapyAcute post-operative painAcute nociceptive painPost-mastectomy painChronic neuropathic painChronic pain statesPost-operative painBreast-Conserving TherapyBreast cancer surgeryNeuropathic painPostoperative painNociceptive painOperative painPain statesCancer surgeryChronic painPhantom painPainMastectomyTherapy
2007
Buprenorphine: a unique opioid with broad clinical applications.
Vadivelu N, Hines RL. Buprenorphine: a unique opioid with broad clinical applications. Journal Of Opioid Management 2007, 3: 49-58. PMID: 17367094, DOI: 10.5055/jom.2007.0038.Peer-Reviewed Original ResearchConceptsAnti-inflammatory agentsPartial mu agonistRoute of administrationUnique opioidPerioperative painAdequate analgesiaAnalgesic potentialMu agonistsBroad clinical applicationOpioid addictionAddictive potentialClinical applicationBuprenorphineAgonistsPositive resultsAnalgesiaMedicationsOpioidsPainAdministration
2000
Ketamine-fentanyl-midazolam infusion for the control of symptoms in terminal life care
Berger J, Ryan A, Vadivelu N, Merriam P, Rever L, Harrison P. Ketamine-fentanyl-midazolam infusion for the control of symptoms in terminal life care. American Journal Of Hospice And Palliative Medicine® 2000, 17: 127-134. PMID: 11406957, DOI: 10.1177/104990910001700213.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnalgesicsCognition DisordersDrug Therapy, CombinationFemaleFentanylHumansHypnotics and SedativesInfusions, IntravenousKetamineMaleMidazolamMiddle AgedNeoplasmsPainPain MeasurementPsychomotor AgitationReceptors, N-Methyl-D-AspartateRetrospective StudiesTerminal CareTreatment Outcome