Morgan Levine, PhD

Assistant Professor Adjunct in Pathology

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Appointments

Pathology

Primary

Contact Info

morgan.levine@yale.edu

About

Titles

Assistant Professor Adjunct in Pathology

Biography

Morgan Levine was previously a tenure-track Assistant Professor in the department of Pathology at Yale University where she ran the Laboratory for Aging in Living Systems. In 2022, she was recruited to join Altos Labs as a Founding Principal Investigator at the San Diego Institute of Science. She currently leads a research group at Altos Labs working at the intersection of bioinformatics, cellular biology, complex systems, and biostatistics with the overall goal of understanding the molecular trajectories aging cells, tissues, and organisms take through time.

Appointments

Pathology
Assistant Professor Adjunct
Primary
Pathology

Alzheimer's Disease Research Center (ADRC)
Center for Biomedical Data Science
Informatics Program
Pathology
Yale Cancer Center

Education & Training

Postdoctoral Fellow: UCLA (2017)

PhD: University of Southern California, Gerontology (2015)

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Research

Overview

Research in the Levine lab focuses on modeling epigenetic changes in aging. To do this, we use data from human and rodent cell culture and primary tissue samples to probe the causes and consequences of aging-related alterations in DNA methylation. We are also actively involved in the development of biomarkers of aging. Our ability to "quantify aging" will facilitate basic and observational research by 1) drastically shortening the time needed to screen therapeutics targeting aging, 2) helping to identify genetic and behavioral factors that influence lifespan and healthspan, and 3) informing our framework of Theories of Aging.

Medical Research Interests

Aging; Algorithms; Alzheimer Disease; Biostatistics; Cellular Senescence; Clonal Evolution; Computational Biology; DNA Methylation; Energy Intake; Gene Expression Profiling; Gene Regulatory Networks; Genetic Variation; Longevity; Stem Cells

ORCID
0000-0001-9890-9324
Lab for Aging in Living Systems (ALIS)
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Research at a Glance

Yale Co-Authors

Frequent collaborators of Morgan Levine's published research.

Albert Higgins-Chen, MD/PhD
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Xi Chen, PhD
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Barbara Burtness, MD
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Sangchoon Jeon, PhD
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Heather Allore, PhD
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Henry S. Park, MD, MPH
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Publications

2024

2023

OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
Sturm G, Karan K, Monzel A, Santhanam B, Taivassalo T, Bris C, Ware S, Cross M, Towheed A, Higgins-Chen A, McManus M, Cardenas A, Lin J, Epel E, Rahman S, Vissing J, Grassi B, Levine M, Horvath S, Haller R, Lenaers G, Wallace D, St-Onge M, Tavazoie S, Procaccio V, Kaufman B, Seifert E, Hirano M, Picard M. OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases. Communications Biology 2023, 6: 22. PMID: 36635485, PMCID: PMC9837150, DOI: 10.1038/s42003-022-04303-x.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2022

The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.
Fiorito G, Pedron S, Ochoa-Rosales C, McCrory C, Polidoro S, Zhang Y, Dugué PA, Ratliff S, Zhao WN, McKay GJ, Costa G, Solinas MG, Harris KM, Tumino R, Grioni S, Ricceri F, Panico S, Brenner H, Schwettmann L, Waldenberger M, Matias-Garcia PR, Peters A, Hodge A, Giles GG, Schmitz LL, Levine M, Smith JA, Liu Y, Kee F, Young IS, McGuinness B, McKnight AJ, van Meurs J, Voortman T, Kenny RA, Vineis P, Carmeli C. The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis. The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences 2022, 77: 1750-1759. PMID: 35172329, DOI: 10.1093/gerona/glac041.
Peer-Reviewed Original Research
Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease
Thrush KL, Bennett DA, Gaiteri C, Horvath S, Dyck CHV, Higgins-Chen AT, Levine ME. Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease. Aging 2022, 14: 5641-5668. PMID: 35907208, PMCID: PMC9365556, DOI: 10.18632/aging.204196.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking
Higgins-Chen AT, Thrush KL, Wang Y, Minteer CJ, Kuo PL, Wang M, Niimi P, Sturm G, Lin J, Moore AZ, Bandinelli S, Vinkers CH, Vermetten E, Rutten BPF, Geuze E, Okhuijsen-Pfeifer C, van der Horst MZ, Schreiter S, Gutwinski S, Luykx JJ, Picard M, Ferrucci L, Crimmins EM, Boks MP, Hägg S, Hu-Seliger TT, Levine ME. A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking. Nature Aging 2022, 2: 644-661. PMID: 36277076, PMCID: PMC9586209, DOI: 10.1038/s43587-022-00248-2.
Peer-Reviewed Original Research
MeSH Keywords
Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study
Cao X, Ma C, Zheng Z, He L, Hao M, Chen X, Crimmins EM, Gill TM, Levine ME, Liu Z. Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study. EClinicalMedicine 2022, 51: 101548. PMID: 35844770, PMCID: PMC9284373, DOI: 10.1016/j.eclinm.2022.101548.
Peer-Reviewed Original Research
Concepts
Life course traumas and cardiovascular disease—the mediating role of accelerated aging
Cao X, Zhang J, Ma C, Li X, Kuo C, Levine ME, Hu G, Allore H, Chen X, Wu X, Liu Z. Life course traumas and cardiovascular disease—the mediating role of accelerated aging. Annals Of The New York Academy Of Sciences 2022, 1515: 208-218. PMID: 35725988, PMCID: PMC10145586, DOI: 10.1111/nyas.14843.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination
Pang APS, Higgins-Chen AT, Comite F, Raica I, Arboleda C, Went H, Mendez T, Schotsaert M, Dwaraka V, Smith R, Levine ME, Ndhlovu LC, Corley MJ. Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination. Frontiers In Genetics 2022, 13: 819749. PMID: 35719387, PMCID: PMC9203887, DOI: 10.3389/fgene.2022.819749.
Peer-Reviewed Original Research
Concepts
Resilience integrates concepts in aging research
Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME. Resilience integrates concepts in aging research. IScience 2022, 25: 104199. PMID: 35494229, PMCID: PMC9044173, DOI: 10.1016/j.isci.2022.104199.
Peer-Reviewed Original Research
Concepts

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News & Links

News

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Get In Touch

Contacts

morgan.levine@yale.edu

Locations

Brady Memorial Laboratory
Lab
310 Cedar Street
New Haven, CT 06510
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Appointments

Contact Info

Titles

Biography

Appointments

Pathology

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

ORCID

Lab for Aging in Living Systems (ALIS)

Research at a Glance

Yale Co-Authors

Albert Higgins-Chen, MD/PhD

Xi Chen, PhD

Barbara Burtness, MD

Sangchoon Jeon, PhD

Heather Allore, PhD

Henry S. Park, MD, MPH

Publications

2024

2023

2022

News

Cellular “Fingerprint” May Offer Early Warning of Cancer Risk

Morgan Levine: 'Only 10-30% of our lifespan is estimated to be due to genetics'

Research Reveals “Biologically Older” Tissue in Patients With Breast Cancer

Forever Young: Searching for the Fountain of Youth

Related Links

Contacts

Locations

Brady Memorial Laboratory