2016
Activation of α7 nicotinic acetylcholine receptors facilitates long-term potentiation at the hippocampal-prefrontal cortex synapses in vivo
Stoiljkovic M, Kelley C, Nagy D, Hurst R, Hajós M. Activation of α7 nicotinic acetylcholine receptors facilitates long-term potentiation at the hippocampal-prefrontal cortex synapses in vivo. European Neuropsychopharmacology 2016, 26: 2018-2023. PMID: 27866776, DOI: 10.1016/j.euroneuro.2016.11.003.Peer-Reviewed Original ResearchConceptsHippocampal-medial prefrontal cortex pathwayHippocampal-prefrontal cortex pathwayLong-term potentiationPrefrontal cortex pathwayCognitive processesCortex pathwayCognitive effectsMnemonic functionsCognitive functionMemory formationNeurophysiological effectsΑ7-nAChR activationNAChR activationΑ7 nAChRsHippocampal long-term potentiationSubiculum regionsΑ7 nicotinic acetylcholine receptorNicotinic acetylcholine receptorsMale ratsSaline controlsSynaptic transmissionBrain slicesTetanic stimulationAcetylcholine receptorsSynaptic plasticitySelective activation of α7 nicotinic acetylcholine receptors augments hippocampal oscillations
Stoiljkovic M, Kelley C, Nagy D, Leventhal L, Hajós M. Selective activation of α7 nicotinic acetylcholine receptors augments hippocampal oscillations. Neuropharmacology 2016, 110: 102-108. PMID: 27422408, DOI: 10.1016/j.neuropharm.2016.07.010.Peer-Reviewed Original ResearchConceptsΑ7 nicotinic acetylcholine receptorNicotinic acetylcholine receptorsΑ7 nAChRsHippocampal oscillationsPNU-282987Acetylcholine receptorsAlzheimer's diseasePotential pharmacologic targetWild-type miceSelective activationNeuronal network oscillationsTheta powerΑ7KO miceHippocampal theta oscillationsClinical evidenceControl micePreclinical observationsUrethane anesthesiaProcognitive activityProcognitive effectsPharmacologic targetAgonistsCognitive deficitsHippocampal activityΑ7Hippocampal network dynamics in response to α7 nACh receptors activation in amyloid-β overproducing transgenic mice
Stoiljkovic M, Kelley C, Hajós GP, Nagy D, Koenig G, Leventhal L, Hajós M. Hippocampal network dynamics in response to α7 nACh receptors activation in amyloid-β overproducing transgenic mice. Neurobiology Of Aging 2016, 45: 161-168. PMID: 27459936, DOI: 10.1016/j.neurobiolaging.2016.05.021.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseΑ7 nicotinic acetylcholine receptorEffect of α7Wild-type miceGamma oscillationsNicotinic acetylcholine receptorsHippocampal network dynamicsSymptomatic treatmentClinical findingsAD patientsSaline controlsProcognitive drugsΑ7 nAChRsTransgenic miceAcetylcholine receptorsReceptor activationCognitive functionHippocampal oscillationsMiceNeurophysiological impairmentsAgonistsPower of thetaΑ7AβSignificant differences
2015
Modulation of hippocampal neuronal network oscillations by α7 nACh receptors
Stoiljkovic M, Kelley C, Nagy D, Hajós M. Modulation of hippocampal neuronal network oscillations by α7 nACh receptors. Biochemical Pharmacology 2015, 97: 445-453. PMID: 26206189, DOI: 10.1016/j.bcp.2015.06.031.Peer-Reviewed Original ResearchConceptsNucleus pontis oralisNeuronal network oscillationsΑ7 nAChRsHippocampal oscillationsNetwork oscillationsBrainstem nucleus pontis oralisHippocampal-dependent cognitive functionsHippocampal thetaTheta-phase gamma-amplitude couplingΑ7 nicotinic acetylcholine receptorHigh-frequency stimulationΑ7 nACh receptorsNicotinic acetylcholine receptorsNeuronal network activityNetwork activityPyramidal neuronsFrequency stimulationPontis oralisPharmacological effectsPreclinical screeningNACh receptorsAcetylcholine receptorsSuch drugsCognitive functionHippocampus