2000
Therapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery.
Laham R, Post M, Sellke F, Simons M. Therapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery. Current Interventional Cardiology Reports 2000, 2: 213-217. PMID: 11096670.Peer-Reviewed Original ResearchIschemic heart diseaseTherapeutic angiogenesisHeart diseaseCoronary artery bypass surgeryPericardial deliveryPotential new treatment strategyLocal perivascular deliveryArtery bypass surgeryNew treatment strategiesGrowth factor-induced angiogenesisClinical therapeutic angiogenesisNew blood vesselsBypass surgeryPerivascular deliveryIschemic myocardiumEpicardial vesselsTreatment strategiesAngiogenic cytokinesTheoretic advantagesSustained exposureBlood vesselsAngiogenesisDelivery modalitiesLimited dataPoor understanding
1999
Local Perivascular Delivery of Basic Fibroblast Growth Factor in Patients Undergoing Coronary Bypass Surgery
Laham R, Sellke F, Edelman E, Pearlman J, Ware J, Brown D, Gold J, Simons M. Local Perivascular Delivery of Basic Fibroblast Growth Factor in Patients Undergoing Coronary Bypass Surgery. Circulation 1999, 100: 1865-1871. PMID: 10545430, DOI: 10.1161/01.cir.100.18.1865.Peer-Reviewed Original ResearchMeSH KeywordsAlginatesCoronary Artery BypassCoronary VesselsDelayed-Action PreparationsDouble-Blind MethodDrug CarriersDrug CompoundingDrug ImplantsFemaleFibroblast Growth Factor 2Follow-Up StudiesGlucuronic AcidHeparinHexuronic AcidsHumansMaleMiddle AgedPatient SelectionPlacebosRecombinant ProteinsConceptsBasic fibroblast growth factorBFGF groupFibroblast growth factorTreatment-related adverse eventsQ-wave myocardial infarctionGrowth factorLocal perivascular deliverySerum bFGF levelsPlacebo-controlled studyCoronary bypass surgerySubset of patientsMode of therapyMagnetic resonance assessmentPromising treatment strategyNuclear perfusionOperative deathsRecurrent anginaStandard revascularizationNew blood vesselsPlacebo groupRepeat revascularizationAdverse eventsBypass surgeryControl patientsPerivascular delivery