2025
Bridging Care Gaps for Older Women Undergoing Percutaneous Coronary Intervention
Kalra K, Sampath R, Cigarroa N, Sutton N, Damluji A, Nanna M. Bridging Care Gaps for Older Women Undergoing Percutaneous Coronary Intervention. Interventional Cardiology Clinics 2025, 14: 69-79. PMID: 39537289, DOI: 10.1016/j.iccl.2024.08.006.Peer-Reviewed Original Research
2024
Short versus 1-Year Dual Antiplatelet Therapy after Percutaneous Coronary Intervention: An Updated Systematic Review and Meta-Analysis
Joseph M, Krishna M, Ezenna C, Pereira V, Ismayl M, Nanna M, Bangalore S, Goldsweig A. Short versus 1-Year Dual Antiplatelet Therapy after Percutaneous Coronary Intervention: An Updated Systematic Review and Meta-Analysis. The American Journal Of Cardiology 2024 PMID: 39577682, DOI: 10.1016/j.amjcard.2024.10.038.Peer-Reviewed Original ResearchPost-percutaneous coronary interventionAcute coronary syndromeDrug-eluting stentsPercutaneous coronary interventionCoronary interventionAcute coronary syndrome cohortCochrane Central databasesShortening DAPT durationMonths post-percutaneous coronary interventionClopidogrel subgroupRandomized controlled trialsNo significant differenceCoronary syndromeMonotherapyTicagrelor monotherapyDAPT durationShorter DAPTBleedingStent thrombosisP2Y12iMyocardial infarctionControlled trialsSubgroup interactionsDAPTMeta-analysisThe Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation A Nationwide Population Study
Mark J, Colombo R, Alfonso C, Llanos A, Collado E, Larned J, Giese G, Dyal M, Nanna M, Damluji A. The Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation A Nationwide Population Study. JACC Advances 2024, 3: 101358. PMID: 39600986, PMCID: PMC11588852, DOI: 10.1016/j.jacadv.2024.101358.Peer-Reviewed Original ResearchAdverse cardiovascular eventsCatheter ablationAtrial fibrillationCardiovascular eventsHeart failureFrail patientsHospital lengthNonfrail patientsReducing major adverse cardiovascular eventsAssociated with worse outcomesMajor adverse cardiovascular eventsReduced ejection fractionHospital length of stayIn-hospital mortalityLonger hospital lengthAssociated with increased oddsDischarge dispositionInfluence of frailtyMultivariate regression analysisNationwide Inpatient SampleImpact of frailtyLength of stayPrevalence of frailtyEjection fractionJohns Hopkins Adjusted Clinical GroupsInvasive Versus Conservative Strategy in Older Adults ≥75 Years of Age With Non-ST-segment-Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Rout A, Moumneh M, Kalra K, Singh S, Garg A, Kunadian V, Biscaglia S, Alkhouli M, Rymer J, Batchelor W, Nanna M, Damluji A. Invasive Versus Conservative Strategy in Older Adults ≥75 Years of Age With Non-ST-segment-Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal Of The American Heart Association 2024, 13: e036151. PMID: 39494560, DOI: 10.1161/jaha.124.036151.Peer-Reviewed Original ResearchConceptsNon-ST segment elevation acute coronary syndromeAcute coronary syndromeComposite of deathBurden of geriatric conditionsRandomized controlled trialsCoronary syndromeMyocardial infarctionYears of ageInvasive strategyOlder adultsControlled trialsGeriatric conditionsOlder patientsCardiovascular deathOdds ratioMeta-analysis of randomized controlled trialsNon-ST segment elevationSecondary end pointsMeta-analysisFixed effects meta-analysisAll-cause deathEffects meta-analysisYounger patientsFollow-upDecreased riskThe Impact of Socioeconomic Status and Diagnostic Timeline on Clinical Outcomes in ATTR Cardiomyopathy
Chi K, Gallegos-Kattán C, Sikand N, Samsky M, Nanna M. The Impact of Socioeconomic Status and Diagnostic Timeline on Clinical Outcomes in ATTR Cardiomyopathy. Journal Of The American College Of Cardiology 2024, 84: e289-e290. PMID: 39505422, DOI: 10.1016/j.jacc.2024.07.050.Peer-Reviewed Original ResearchOral anticoagulants or antiplatelets for cryptogenic stroke: a systematic review and meta-analysis
Chi K, Song J, Zarif T, Chiang C, Lee P, Chang Y, Nanna M, Nanna M. Oral anticoagulants or antiplatelets for cryptogenic stroke: a systematic review and meta-analysis. European Heart Journal 2024, 45: ehae666.2309. DOI: 10.1093/eurheartj/ehae666.2309.Peer-Reviewed Original ResearchLeft atrial diameterRelevant randomized controlled trialsPatent foramen ovaleNAVIGATE ESUS trialOral anticoagulantsOral anticoagulant useRecurrent ischemic strokeCryptogenic strokeIschemic strokeMeta-analysisSubgroup analysisESUS patientsHazard ratioSafety of oral anticoagulantsInternational Society of ThrombosisSociety of ThrombosisOptimal antithrombotic strategyAtrial cardiopathyDiagnostic work-upRE-SPECT ESUSElectronic databases of PubMedCryptogenic stroke patientsSources of cardioembolismRandom-effects meta-analysisSystematic reviewMortality effects of beta-blockers on myocardial infarction in patients without reduced ejection fraction or heart failure in the contemporary reperfusion era : a systematic review and meta-analysis
Y K, Lee P, Chowdhury I, Schwartz R, Kang Y, Mangalesh S, Babapour G, Akman Z, Chang Y, Song J, Lessa Y, Damluji A, Nanna M, Nanna M. Mortality effects of beta-blockers on myocardial infarction in patients without reduced ejection fraction or heart failure in the contemporary reperfusion era : a systematic review and meta-analysis. European Heart Journal 2024, 45: ehae666.1640. DOI: 10.1093/eurheartj/ehae666.1640.Peer-Reviewed Original ResearchRandomized controlled trialsReduced ejection fractionBeta-blockersEjection fractionHeart failureMortality benefitReduced EFMeta-regressionEF patientsPreserved EFBB usersReperfusion eraMeta-analysisSubgroup analysisSystematic reviewPost-MIPost-MI careEffect of beta-blockersIncreased all-cause mortalityHistory of HFEvent-free periodAll-cause mortalityTemporal trendsStudy inclusion periodModern randomized controlled trialsPrognostic Value of Cardiovascular Biomarkers
Mangalesh S, Nanna M. Prognostic Value of Cardiovascular Biomarkers. JAMA 2024, 332: 1302-1303. PMID: 39292479, DOI: 10.1001/jama.2024.16522.Peer-Reviewed Original ResearchValidating the PREVENT Equations—A Contemporary Update to Cardiovascular Risk Assessment
Mangalesh S, Nanna M. Validating the PREVENT Equations—A Contemporary Update to Cardiovascular Risk Assessment. JAMA Network Open 2024, 7: e2438284. PMID: 39392636, DOI: 10.1001/jamanetworkopen.2024.38284.Peer-Reviewed Original ResearchBeta-blockers for secondary prevention following myocardial infarction in patients without reduced ejection fraction or heart failure: an updated meta-analysis
Chi K, Lee P, Chowdhury I, Akman Z, Mangalesh S, Song J, Satish V, Babapour G, Kang Y, Schwartz R, Chang Y, Borkowski P, Nanna M, Damluji A, Nanna M. Beta-blockers for secondary prevention following myocardial infarction in patients without reduced ejection fraction or heart failure: an updated meta-analysis. European Journal Of Preventive Cardiology 2024, zwae298. PMID: 39298680, DOI: 10.1093/eurjpc/zwae298.Peer-Reviewed Original ResearchReduced ejection fractionBeta-blockersEjection fractionHeart failureMortality benefitBB useReduced EFCV mortalityPost-MIRandom-effects meta-analysisMeta-analysisHistory of HFAll-cause mortalityTemporal trendsPrespecified subgroup analysesEvent-free periodCardiovascular (CVIncreased CV mortalityStudy inclusion periodPost-myocardial infarctionContemporary dataAssociated with detrimental effectsNon-significant trendSecondary preventionBB usersComparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis
Fallahtafti P, Soleimani H, Ebrahimi P, Ghaseminejad‐Raeini A, Karimi E, Shirinezhad A, Sabri M, Mehrani M, Taheri H, Siegel R, Shah N, Nanna M, Hakim D, Hosseini K. Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis. Clinical Cardiology 2024, 47: e24324. PMID: 39054901, PMCID: PMC11272956, DOI: 10.1002/clc.24324.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCoronary artery diseasePercutaneous coronary interventionIn-hospital mortalityNetwork meta-analysisMyocardial infarctionAortic stenosisAssociated with worse 30-day outcomeMeta-analysisIncreased risk of 1-year mortalityAssociated with higher 1-year mortalityRisk of 1-year mortalitySevere aortic stenosisFrequentist network meta-analysisRates of myocardial infarctionPercutaneous coronary intervention timeTime of revascularizationAortic valve implantationSevere ASNo significant differencePacemaker implantationPost-TAVIValve implantationPatient characteristicsArtery diseaseTrend of Controlled Low-Density Lipoprotein Cholesterol in Older Adults With a History of Myocardial Infarction or Stroke
Park D, Jamil Y, Frampton J, Al Damluji A, Nanna M. Trend of Controlled Low-Density Lipoprotein Cholesterol in Older Adults With a History of Myocardial Infarction or Stroke. JACC Advances 2024, 3: 101091. PMID: 39099776, PMCID: PMC11294686, DOI: 10.1016/j.jacadv.2024.101091.Peer-Reviewed Original ResearchSearching for Meaning Refining Troponin Thresholds to Align Risks Between Spontaneous and Procedural Myocardial Infarction
Nanna M, Mangalesh S. Searching for Meaning Refining Troponin Thresholds to Align Risks Between Spontaneous and Procedural Myocardial Infarction. Journal Of The American College Of Cardiology 2024, 84: 478-481. PMID: 39048280, DOI: 10.1016/j.jacc.2024.05.042.Peer-Reviewed Original ResearchAssociation Between Body Mass Index, Testing Performance And Clinical Outcomes In Patients With Stable Chest Pain: Insights From The PRECISE (Prospective Randomized Trial Of The Optimal Evaluation Of Cardiac Symptoms And Revascularization) Trial
Ferencik M, Vemulapalli S, Nanna M, Kelsey M, Mark D, Leipsic J, Ng N, Maurovich-Horvat P, Mullen S, Rogers C, Udelson J, Douglas P. Association Between Body Mass Index, Testing Performance And Clinical Outcomes In Patients With Stable Chest Pain: Insights From The PRECISE (Prospective Randomized Trial Of The Optimal Evaluation Of Cardiac Symptoms And Revascularization) Trial. Journal Of Cardiovascular Computed Tomography 2024, 18: s38. DOI: 10.1016/j.jcct.2024.05.087.Peer-Reviewed Original ResearchPercutaneous Coronary Revascularization Strategies After Myocardial Infarction A Systematic Review and Network Meta-Analysis
Reddy R, Howard J, Jamil Y, Madhavan M, Nanna M, Lansky A, Leon M, Ahmad Y. Percutaneous Coronary Revascularization Strategies After Myocardial Infarction A Systematic Review and Network Meta-Analysis. Journal Of The American College Of Cardiology 2024, 84: 276-294. PMID: 38986670, DOI: 10.1016/j.jacc.2024.04.051.Peer-Reviewed Original ResearchConceptsRelative riskCardiovascular mortalityMyocardial infarctionMultivessel coronary artery diseaseAll-cause mortalityAdverse cardiac eventsST-segment elevation myocardial infarctionComplete revascularizationCoronary artery diseaseBayesian network meta-analysesMortality reductionA systematic reviewNetwork meta-analysesElevation myocardial infarctionSystematic reviewMeta-analysesCardiac eventsArtery diseasePrimary outcomeNetwork meta-analysisRevascularization strategyMeta-analysisHead-to-head trialsCoronary revascularization strategyAcute kidney injuryRepresentation of Older Adults in the ACC/AHA/SCAI Guideline for Coronary Artery Revascularization
Jamil Y, Sibindi C, Park D, Frampton J, Damluji A, Nanna M. Representation of Older Adults in the ACC/AHA/SCAI Guideline for Coronary Artery Revascularization. JAMA Network Open 2024, 7: e2421547. PMID: 38995647, PMCID: PMC11245718, DOI: 10.1001/jamanetworkopen.2024.21547.Peer-Reviewed Original ResearchApixaban to Prevent Recurrence After Cryptogenic Stroke
Chi K, Nanna M, Nanna M. Apixaban to Prevent Recurrence After Cryptogenic Stroke. JAMA 2024, 331: 1965-1966. PMID: 38739398, DOI: 10.1001/jama.2024.6851.Peer-Reviewed Original ResearchQuality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial
Park D, Jamil Y, Moumneh M, Batchelor B W, Nanna M, Damluji A. Quality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial. The American Journal Of Cardiology 2024, 223: 58-69. PMID: 38797195, PMCID: PMC11214881, DOI: 10.1016/j.amjcard.2024.05.016.Peer-Reviewed Original ResearchDuke Activity Status IndexOlder adultsYears of follow-upStable ischemic heart diseaseIntensive medical therapyQoL measuresStatus indexIschemic heart diseaseDistress ratingsOlder adult populationOlder adult patientsBARI 2D trialDiabetes mellitusQuality of lifeQuality-of-lifeHeart diseaseMultivariate linear regressionFollow-upMedical therapyAdult populationQoLCognitive impairmentOlder patientsPost hoc analysisChronic total occlusionMachine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients
Hosseini K, Behnoush A, Khalaji A, Etemadi A, Soleimani H, Pasebani Y, Jenab Y, Masoudkabir F, Tajdini M, Mehrani M, Nanna M. Machine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients. International Journal Of Cardiology 2024, 409: 132191. PMID: 38777044, DOI: 10.1016/j.ijcard.2024.132191.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLogistic regressionPost-PCI mortalityPrediction of one-year mortalityCoronary interventionPrediction of 1-year mortalityBody mass indexAcute coronary syndrome patientsOne-year mortalityIndividual-level assessmentsReceiver operating characteristic curveAcute coronary syndromeCoronary syndrome patientsTehran Heart CenterRates of comorbiditiesMass indexHigher ageSyndrome patientsCoronary syndromeHeart CenterFollow-upLipid profileU-shaped correlationPatientsCharacteristic curveAssociation Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock
Jamil Y, Park D, Rao S, Ahmad Y, Sikand N, Bosworth H, Coles T, Damluji A, Nanna M, Samsky M. Association Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock. JACC Advances 2024, 3: 100949. PMID: 38938859, PMCID: PMC11198471, DOI: 10.1016/j.jacadv.2024.100949.Peer-Reviewed Original ResearchAcute myocardial infarctionAMI-CSIn-hospital outcomesDo-not-resuscitate statusPatients admitted with acute myocardial infarctionOdds of in-hospital mortalitySkilled nursing facilityPrevalence of frailtyProportion of hospitalsAssociated with in-hospital outcomesIn-hospital adverse eventsCompare in-hospital outcomesRisk score cut-offNational Inpatient SampleNursing facilitiesIn-hospital mortalityScore cut-offAssociated with adverse outcomesInpatient SampleFrailtyCardiogenic shockIn-hospital morbidityMyocardial infarction complicationsNonfrail groupOdds