1998
Role of heat stress response in the tolerance of immature renal tubules to anoxia
Gaudio K, Thulin G, Mann A, Kashgarian M, Siegel N. Role of heat stress response in the tolerance of immature renal tubules to anoxia. American Journal Of Physiology 1998, 274: f1029-f1036. PMID: 9841493, DOI: 10.1152/ajprenal.1998.274.6.f1029.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBlotting, NorthernCarbonyl Cyanide m-Chlorophenyl HydrazoneCell HypoxiaDNA, MitochondrialDNA-Binding ProteinsElectrophoresisHeat Shock Transcription FactorsHeat-Shock ProteinsHot TemperatureHSP72 Heat-Shock ProteinsKidney TubulesMitochondriaNystatinOuabainOxygen ConsumptionRatsRNA, MessengerTranscription Factors
1993
Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.
Soifer N, Van Why S, Ganz M, Kashgarian M, Siegel N, Stewart A. Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia. Journal Of Clinical Investigation 1993, 92: 2850-2857. PMID: 8254039, PMCID: PMC288486, DOI: 10.1172/jci116905.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid IsomerasesAnimalsBlotting, NorthernCarrier ProteinsGene ExpressionImmunohistochemistryIschemiaKidneyKidney GlomerulusKidney TubulesMaleParathyroid Hormone-Related ProteinPeptidylprolyl IsomeraseProtein BiosynthesisProteinsRatsRats, Sprague-DawleyReceptors, Parathyroid HormoneReference ValuesRenal ArteryReperfusionRNA, MessengerConceptsHormone-related proteinMesangial cellsTubular cellsAcute renal ischemic injuryBilateral renal artery occlusionMale Sprague-Dawley ratsParathyroid hormone-related proteinAutocrine/paracrine fashionPTHrP mRNA levelsRenal artery occlusionRenal ischemic injuryMRNA levelsSprague-Dawley ratsDistal tubular cellsSham-operated animalsCyclophilin mRNA levelsProximal tubular cellsLocalization of PTHrPCultured mesangial cellsLocal growth factorsAdult rat kidneyArtery occlusionGlomerular epithelial cellsRenal injuryIschemic injury
1991
Redistribution of cellular energy following renal ischemia
Gaudio K, Thulin G, Ardito T, Kashgarian M, Siegel N. Redistribution of cellular energy following renal ischemia. Pediatric Nephrology 1991, 5: 591-596. PMID: 1911145, DOI: 10.1007/bf00856647.Peer-Reviewed Original Research
1990
Morphological and physiological responses to aldosterone: time course and sodium dependence
Wade J, Stanton B, Field M, Kashgarian M, Giebisch G. Morphological and physiological responses to aldosterone: time course and sodium dependence. American Journal Of Physiology 1990, 259: f88-f94. PMID: 2375395, DOI: 10.1152/ajprenal.1990.259.1.f88.Peer-Reviewed Original ResearchConceptsOsmotic minipumpsMale Sprague-Dawley ratsPrincipal cellsElevated aldosterone levelsSprague-Dawley ratsImplanted osmotic minipumpsTime courseBasolateral membraneAldosterone levelsIntravenous infusionAldosterone treatmentPhysiological elevationReplacement infusionsAldosteroneAcute exposureChronic exposureDetectable proliferationFurther elevationDays of exposureSodium dependenceBasolateral membrane areaMinipumpsInfusionSecretionExposure
1989
Ankyrin links fodrin to the alpha subunit of Na,K-ATPase in Madin-Darby canine kidney cells and in intact renal tubule cells.
Morrow J, Cianci C, Ardito T, Mann A, Kashgarian M. Ankyrin links fodrin to the alpha subunit of Na,K-ATPase in Madin-Darby canine kidney cells and in intact renal tubule cells. Journal Of Cell Biology 1989, 108: 455-465. PMID: 2537316, PMCID: PMC2115445, DOI: 10.1083/jcb.108.2.455.Peer-Reviewed Original ResearchConceptsMadin-Darby canine kidney cellsCanine kidney cellsK-ATPaseAlpha subunitMolecular mechanismsMDCK cellsMinor membrane proteinsDistribution of fodrinErythrocyte ankyrinConfluent MDCK cellsBinding of ankyrinKidney cellsHuman erythrocyte ankyrinRenal epithelial cellsCytoplasmic domainNonerythroid cellsMembrane proteinsCortical cytoskeletonBasolateral domainMembrane skeletonPolarized distributionAnkyrinBasolateral marginsCell developmentErythrocyte band 3
1988
Morphological heterogeneity of the rabbit collecting duct
Ridderstrale Y, Kashgarian M, Koeppen B, Giebisch G, Stetson D, Ardito T, Stanton B. Morphological heterogeneity of the rabbit collecting duct. Kidney International 1988, 34: 655-670. PMID: 2462075, DOI: 10.1038/ki.1988.230.Peer-Reviewed Original Research[36] Preparation and use of monoclonal antibodies to Na+,K+-ATPase
Kashgarian M, Biemesderfer D. [36] Preparation and use of monoclonal antibodies to Na+,K+-ATPase. Methods In Enzymology 1988, 156: 392-413. PMID: 2835622, DOI: 10.1016/0076-6879(88)56039-1.Peer-Reviewed Original ResearchNa,K-ATPase co-distributes with ankyrin and spectrin in renal tubular epithelial cells.
Kashgarian M, Morrow J, Foellmer H, Mann A, Cianci C, Ardito T. Na,K-ATPase co-distributes with ankyrin and spectrin in renal tubular epithelial cells. Progress In Clinical And Biological Research 1988, 268B: 245-50. PMID: 2851802.Peer-Reviewed Original Research
1987
Parathyroid hormone directly inhibits tubular reabsorption of bicarbonate in normocalcaemic rats with chronic hyperparathyroidism
JAEGER P, JONES W, KASHGARIAN M, SEGRE G, HAYSLETT J. Parathyroid hormone directly inhibits tubular reabsorption of bicarbonate in normocalcaemic rats with chronic hyperparathyroidism. European Journal Of Clinical Investigation 1987, 17: 415-420. PMID: 3121345, DOI: 10.1111/j.1365-2362.1987.tb01136.x.Peer-Reviewed Original ResearchConceptsParathyroid hormonePTH infusionChronic hyperparathyroidismPlasma calciumAnimal modelsEffect of PTHProximal HCO3 reabsorptionChronic metabolic acidosisGroups of animalsPrimary hyperparathyroidismAlzet minipumpsSerum calciumTubular reabsorptionAcute studyMetabolic acidosisMetabolic alkalosisRenal handlingTubular acidificationAcid secretionGroup IIHCO3- reabsorptionFree dietHyperparathyroidismCa-free dietNormal levelsResponse of collecting tubule cells to aldosterone and potassium loading
Kashgarian M, Ardito T, Hirsch D, Hayslett J. Response of collecting tubule cells to aldosterone and potassium loading. American Journal Of Physiology 1987, 253: f8-f14. PMID: 3605352, DOI: 10.1152/ajprenal.1987.253.1.f8.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCortical collecting tubuleBasolateral membrane surfaceCollecting tubuleChronic potassium loadingElevated levelsDuct structuresPotassium loadingSite of actionPlasma levelsRat modelOuter stripeInner stripeTubule cellsNormal physiological levelsControl valuesAldoMorphometric studyAldosteronePhysiological levelsDuct systemTubulesConcomitant changesDuct
1984
Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule
Hirsch D, Kashgarian M, Boulpaep E, Hayslett J. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney International 1984, 26: 798-807. PMID: 6099857, DOI: 10.1038/ki.1984.221.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCollecting tubuleDistal convolutionAldosterone levelsPotassium adaptationChronic potassium loadingMineralocorticoid-sensitive tissuesRole of aldosteronePlasma aldosterone levelsAction of aldosteroneIntact adrenal glandsPotassium loadingPhysiological plasma levelsChronic hyperaldosteronismTransepithelial potential differenceChronic administrationEpithelial changesAdrenal glandPlasma levelsDietary potassium loadingBasal valuesAldosteroneTubule cellsNephron segmentsTarget tissues
1982
Lysosomal enzymes in glomerular cells of the rat.
Lovett D, Ryan J, Kashgarian M, Sterzel R. Lysosomal enzymes in glomerular cells of the rat. American Journal Of Pathology 1982, 107: 161-6. PMID: 6282126, PMCID: PMC1916002.Peer-Reviewed Original Research
1980
Changes in membrane surfaces of collecting duct cells in potassium adaptation
Rastegar A, Biemesderfer D, Kashgarian M, Hayslett J, Kashgarian M. Changes in membrane surfaces of collecting duct cells in potassium adaptation. Kidney International 1980, 18: 293-301. PMID: 6257963, DOI: 10.1038/ki.1980.139.Peer-Reviewed Original Research
1979
A micropuncture study of the renal handling of lithium
Hayslett J, Kashgarian M. A micropuncture study of the renal handling of lithium. Pflügers Archiv - European Journal Of Physiology 1979, 380: 159-163. PMID: 573443, DOI: 10.1007/bf00582152.Peer-Reviewed Original ResearchConceptsMicropuncture studiesProximal tubulesLoop of HenleTubular fluid samplesNephron sitesNet transepithelial movementRenal handlingLithium reabsorptionDistal tubulesClearance studiesTubular fluidProximal convolutionExperimental animalsDistal portionFluid samplesTubulesTransepithelial movementHenleNephron
1978
Effects of potassium depletion on renal tubular chloride transport in the rat
Luke R, Wright F, Fowler N, Kashgarian M, Giebisch G. Effects of potassium depletion on renal tubular chloride transport in the rat. Kidney International 1978, 14: 414-427. PMID: 35645, DOI: 10.1038/ki.1978.146.Peer-Reviewed Original ResearchConceptsEarly distal tubuleLoop of HenleDistal tubulesKD groupChloride reabsorptionProximal tubulesPotassium depletionAbsolute chloride reabsorptionAdministration of DOCASingle nephron GFRRenal tubular reabsorptionPotassium-depleted ratsLate distal tubuleEffects of KDNephron GFRTubular reabsorptionChloride intakeFractional reabsorptionClearance studiesDay 2Fractional deliveryMuscle potassiumWhole kidneyDay 9RatsMicropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney
Hecht B, Kashgarian M, Forrest J, Hayslett J. Micropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney. Pflügers Archiv - European Journal Of Physiology 1978, 377: 69-74. PMID: 569282, DOI: 10.1007/bf00584376.Peer-Reviewed Original ResearchConceptsFractional reabsorptionDistal tubule functionProximal fractional reabsorptionPlasma lithium concentrationReabsorption of bicarbonateMultiple nephron segmentsEnd-proximal tubuleEffects of lithiumLithium treatmentPotassium secretionAntidiuretic hormoneDistal tubulesMicropuncture studiesTubule functionProximal tubulesDistal convolutionExperimental animalsNephron segmentsReabsorptionDistal portionTubulesPrevious studiesRatsSodiumHormone
1977
Electrical characteristics of the mammalian distal tubule: Comparison of Ling-Gerard and macroelectrodes
Hayslett J, Boulpaep E, Kashgarian M, Giebisch G. Electrical characteristics of the mammalian distal tubule: Comparison of Ling-Gerard and macroelectrodes. Kidney International 1977, 12: 324-331. PMID: 604621, DOI: 10.1038/ki.1977.119.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsElectricityElectrodesFemaleKidney TubulesKidney Tubules, DistalMaleMicroelectrodesNephronsRats
1973
Increased tubular reabsorption of sodium in compensatory renal growth
Weinman E, Renquist K, Stroup R, Kashgarian M, Hayslett J. Increased tubular reabsorption of sodium in compensatory renal growth. American Journal Of Physiology 1973, 224: 565-571. PMID: 4691269, DOI: 10.1152/ajplegacy.1973.224.3.565.Peer-Reviewed Original Research
1972
Examination of the Gertz technique as applied to the proximal tubule of the rat kidney.
Weinman E, Hardy R, Kashgarian M, Hayslett J. Examination of the Gertz technique as applied to the proximal tubule of the rat kidney. The Yale Journal Of Biology And Medicine 1972, 45: 289-98. PMID: 4638651, PMCID: PMC2591948.Peer-Reviewed Original Research
1971
Role of peritubular protein concentration in sodium reabsorption
Weinman E, Kashgarian M, Hayslett J. Role of peritubular protein concentration in sodium reabsorption. American Journal Of Physiology 1971, 221: 1521-1528. PMID: 5124298, DOI: 10.1152/ajplegacy.1971.221.5.1521.Peer-Reviewed Original Research