2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Urea NitrogenGlomerular Filtration RateKidney DiseasesKidney GlomerulusMiceMice, KnockoutMyosin Type IMyosinsPodocytesConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytes
1993
Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.
Soifer N, Van Why S, Ganz M, Kashgarian M, Siegel N, Stewart A. Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia. Journal Of Clinical Investigation 1993, 92: 2850-2857. PMID: 8254039, PMCID: PMC288486, DOI: 10.1172/jci116905.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid IsomerasesAnimalsBlotting, NorthernCarrier ProteinsGene ExpressionImmunohistochemistryIschemiaKidneyKidney GlomerulusKidney TubulesMaleParathyroid Hormone-Related ProteinPeptidylprolyl IsomeraseProtein BiosynthesisProteinsRatsRats, Sprague-DawleyReceptors, Parathyroid HormoneReference ValuesRenal ArteryReperfusionRNA, MessengerConceptsHormone-related proteinMesangial cellsTubular cellsAcute renal ischemic injuryBilateral renal artery occlusionMale Sprague-Dawley ratsParathyroid hormone-related proteinAutocrine/paracrine fashionPTHrP mRNA levelsRenal artery occlusionRenal ischemic injuryMRNA levelsSprague-Dawley ratsDistal tubular cellsSham-operated animalsCyclophilin mRNA levelsProximal tubular cellsLocalization of PTHrPCultured mesangial cellsLocal growth factorsAdult rat kidneyArtery occlusionGlomerular epithelial cellsRenal injuryIschemic injury
1986
Progressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis
Foellmer H, Sterzel R, Kashgarian M. Progressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis. American Journal Of Kidney Diseases 1986, 7: 5-11. PMID: 3510536, DOI: 10.1016/s0272-6386(86)80050-6.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateAntiglomerular basement membrane glomerulonephritisProgressive glomerular sclerosisGlomerular sclerosisPara-aminohippuric acidGlomerular hypercellularityFiltration fractionWistar ratsInitial inflammatory changesNormal renal clearanceIntrinsic glomerular cellsChronic glomerulosclerosisRenal insufficiencyInflammatory changesAcute phaseChronic phaseSignificant proteinuriaFiltration rateLeukocytic infiltrationCrescent formationFunctional abnormalitiesSclerotic processRenal clearanceGlomerular cellsGlomerulonephritisA Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia
Seney F, Federgreen W, Stein H, Kashgarian M. A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia. JAMA Internal Medicine 1986, 146: 137-141. PMID: 3942445, DOI: 10.1001/archinte.1986.00360130167023.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntigen-Antibody ComplexFemaleGlomerulonephritisHumansKidney GlomerulusLeukemia, LymphoidMaleMiddle AgedNephrotic SyndromeConceptsChronic lymphocytic leukemiaNephrotic syndromeLymphocytic leukemiaNephrotic Syndrome AssociatedCommon glomerular lesionImmune complex diseaseRenal diseaseMembranoproliferative glomerulonephritisCellular immunitySyndrome AssociatedGlomerular lesionsImmunoglobulin productionPatientsAvailable evidenceSyndromeLeukemiaDiseaseGlomerulonephritisLesionsImmunity
1983
Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats.
Stein H, Feddergreen W, Kashgarian M, Sterzel R. Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats. Laboratory Investigation 1983, 49: 270-80. PMID: 6350702.Peer-Reviewed Original ResearchConceptsBlood pressureFiltration fractionMesangial localizationAngiotensin IIFunctional changesAcute angiotensin IIAminohippuric acid clearanceRenal functional changesSystolic blood pressureExcretion of albuminSingle intravenous doseGlomerular capillary permeabilityGroups of ratsInjection of ferritinPressor doseAcid clearanceIntravenous doseMesangial depositionMesangial accumulationFerritin concentrationInulin clearanceTreatment periodRenal tissueSerial measurementsFerritin depositionDisposal of ferritin in the glomerular mesangium of rats
Sterzel R, Perfetto M, Biemesderfer D, Kashgarian M. Disposal of ferritin in the glomerular mesangium of rats. Kidney International 1983, 23: 480-488. PMID: 6188874, DOI: 10.1038/ki.1983.45.Peer-Reviewed Original ResearchConceptsGlomerular mesangiumDay 3DE ratsVascular poleIa-negative cellsMacula densa cellsIa-positive cellsGlomerular stainingMacula densaMesangial patternIntravenous injectionRenal tissueFerritin injectionIa antigensGlomerular tuftBearing cellsMesangial matrixMesangial cellsLacis areaMesangiumRatsCryostat sectionsInterstitial areaStudy periodFerritin
1982
The mesangium and glomerulonephritis
Sterzel R, Lovett D, Stein H, Kashgarian M. The mesangium and glomerulonephritis. Journal Of Molecular Medicine 1982, 60: 1077-1094. PMID: 7144055, DOI: 10.1007/bf01715838.Peer-Reviewed Original ResearchConceptsGlomerular diseaseImmune competent cellsProgressive glomerular sclerosisExperimental glomerular diseaseMesangial cell proliferationMesangial spacePeripheral capillary wallsCertain glomerular diseasesLocal hemodynamic factorsIntrinsic mesangial cellsGlomerular basement membraneMesangial dysfunctionGlomerular sclerosisInflammatory cellsGlomerular hypertensionHistopathologic studyMarked proteinuriaGlomerular disordersSubendothelial depositsPericapillary tissueTherapeutic approachesImmune complexesFunctional damageMesangial abnormalitiesCapillary pericytesLysosomal enzymes in glomerular cells of the rat.
Lovett D, Ryan J, Kashgarian M, Sterzel R. Lysosomal enzymes in glomerular cells of the rat. American Journal Of Pathology 1982, 107: 161-6. PMID: 6282126, PMCID: PMC1916002.Peer-Reviewed Original ResearchMesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats.
Sterzel R, Ehrich J, Lucia H, Thomson D, Kashgarian M. Mesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats. Laboratory Investigation 1982, 46: 209-14. PMID: 7038293.Peer-Reviewed Original ResearchConceptsGlomerular immune depositsImmune depositsElectron-dense depositsDay 10Day 20Young Sprague-Dawley ratsRenal functional damageUrinary protein excretionInfiltration of monocytesGlomerular cell countSprague-Dawley ratsEsterase-positive monocytesGlomerular basement membraneAcute malariaProtein excretionGlomerular injuryMesangial distributionSerum urea valuesDay 100Granular depositionImmune complexesFunctional damageNormal rangeMesangial matrixCell count
1980
The significance of electron dense deposits in mild lupus nephritis.
Domoto D, Kashgarian M, Hayslett J, Adler M, Siegel N. The significance of electron dense deposits in mild lupus nephritis. The Yale Journal Of Biology And Medicine 1980, 53: 317-24. PMID: 7445538, PMCID: PMC2595828.Peer-Reviewed Original ResearchConceptsMild lupusSubendothelial depositsDiffuse proliferative lesionsPercent of patientsDiffuse proliferative glomerulonephritisRate of progressionElectron-dense depositsLupus nephritisSubsequent biopsyPoor prognosisProliferative glomerulonephritisDeteriorating courseMild lesionsProliferative lesionsPatientsProgressionDense depositsLupusLesionsLight microscopyWide variationGlomerulonephritisNephritisBiopsyPrognosis
1976
Hemodynamic aspects in development and recovery phases of experimental postischemic acute renal failure.
Kashgarian M, Siegel N, Ries A, DiMeola H, Hayslett J. Hemodynamic aspects in development and recovery phases of experimental postischemic acute renal failure. Kidney International Supplement 1976, 6: s160-8. PMID: 1068320.Peer-Reviewed Original ResearchLupus nephritis: natural history and therapy.
Hecht B, Siegel N, Kashgarian M, Hayslett J. Lupus nephritis: natural history and therapy. Perspectives In Nephrology And Hypertension 1976, 3: 21-41. PMID: 175347.Peer-Reviewed Original Research
1975
Minimal-lesion nephrotic syndrome with early resistance to steroid therapy
Siegel N, Gur A, Krassner L, Kashgarian M. Minimal-lesion nephrotic syndrome with early resistance to steroid therapy. The Journal Of Pediatrics 1975, 87: 377-380. PMID: 1165516, DOI: 10.1016/s0022-3476(75)80639-1.Peer-Reviewed Original ResearchConceptsMinimal lesion nephrotic syndromeNephrotic syndromeLong-term clinical courseEarly resistanceMinimal glomerular lesionsClinical courseSteroid responsivenessClinical outcomesPrompt remissionCyclophosphamide treatmentGlomerular lesionsHistopathologic lesionsPatientsRemissionCyclophosphamideSyndromeTherapyLesionsUltimate outcomeOutcomesChildrenCorticosteroidsPrednisoneRelapseSteroidsGlomerulonephropathy.
Hayslett J, Siegel N, Kashgarian M. Glomerulonephropathy. Advances In Internal Medicine 1975, 20: 215-48. PMID: 1090119.Peer-Reviewed Original ResearchAdolescentAdultAmyloidosisBasement MembraneBlood Coagulation DisordersChildChild, PreschoolDiabetic NephropathiesFemaleGlomerulonephritisGranulomatosis with PolyangiitisHematuriaHumansImmunoglobulin GImmunoglobulin MKidney DiseasesKidney GlomerulusLupus Erythematosus, SystemicMaleMiddle AgedNephrosis, LipoidProteinuriaStreptococcal InfectionsUremia
1974
Compensatory adaptation of structure and function following progressive renal ablation
Kaufman J, DiMeola H, Siegel N, Lytton B, Kashgarian M, Hayslett J. Compensatory adaptation of structure and function following progressive renal ablation. Kidney International 1974, 6: 10-17. PMID: 4419711, DOI: 10.1038/ki.1974.72.Peer-Reviewed Original ResearchConceptsRenal ablationRenal tissueNephron glomerular filtration rateCompensatory adaptationGlomerular filtration rateClearance of inulinRenal insufficiencyUninephrectomized ratsFour-week intervalsFiltration rateRenal massesGroup BGroup AControl animalsGroup CLE ratsFunctional changesMass of tissueSegmental lossRatsSurgeryAdaptive changesAblationClearanceTissueMinimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis
Siegel N, Kashgarian M, Spargo B, Hayslett J. Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis. Nephron 1974, 13: 125-137. PMID: 4368918, DOI: 10.1159/000180385.Peer-Reviewed Original ResearchConceptsSteroid-sensitive diseaseFocal sclerotic lesionsNephrotic syndromeSclerotic lesionsMinimal change lesionCourse of diseaseMinimal glomerular changesYears of ageLipoid nephrosisSteroid resistanceClinicopathological relationshipRenal biopsyGlomerular changesFocal glomerulosclerosisUltrastructural examinationDiseaseLesionsSyndromeChildrenLight microscopyMinimal changesOnsetEarly evidenceYearsBroad spectrum
1972
CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA
Hendler E, Kashgarian M, Hayslett J. CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA. The Lancet 1972, 299: 458-463. PMID: 4109816, DOI: 10.1016/s0140-6736(72)90121-3.Peer-Reviewed Original ResearchConceptsRenal diseaseProliferative glomerulonephritisPathological lesionsMild proliferative glomerulonephritisUrinary tract lesionsUrinary protein excretionGroup of patientsTypes of glomerulonephritisSevere proliferative glomerulonephritisType of lesionIntercurrent infectionRenal functionRenal biopsyProtein excretionPrimary lesionClinicopathological correlationDistribution of ageCorrect diagnosisPatientsGlomerulonephritisLesionsYoung adultsDiseaseHæmorrhageUseful index
1969
Progression of Lipoid Nephrosis to Renal Insufficiency
Hayslett J, Krassner L, Bensch K, Kashgarian M, Epstein F. Progression of Lipoid Nephrosis to Renal Insufficiency. New England Journal Of Medicine 1969, 281: 181-187. PMID: 5790494, DOI: 10.1056/nejm196907242810402.Peer-Reviewed Original Research
1968
Focal glomerulitis due to penicillamine.
Hayslett J, Bensch K, Kashgarian M, Rosenberg L. Focal glomerulitis due to penicillamine. Laboratory Investigation 1968, 19: 376-81. PMID: 5699118.Peer-Reviewed Original Research